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主营:抗体类、生化类试剂、ELISA试剂盒、组织染色细胞可视化试剂、针对神经科学和细胞疾病研究产品和纯化蛋白等
℡ 4000-520-616
℡ 4000-520-616
Biosensis/Human TrkB-Fc Chimera expressed in mammalian cells/PE-1235-20/20 µg
产品编号:PE-1235-20
市  场 价:¥3940.00
场      地:美国(厂家直采)
产品分类: 生化试剂>生物分子>受体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$197.00
品      牌: Biosensis
公      司:Biosensis
公司分类:
Biosensis/Human TrkB-Fc Chimera expressed in mammalian cells/PE-1235-20/20 µg
商品介绍
DescriptionTyrosineKinaseReceptorB(TrkB)isahighaffinityreceptorforbrain-derivedneurotrophicfactor(BDNF)andneurotrophin-4/5.Italsobindsneurotrophin3(NT-3)withloweraffinity.TrkBdoesnotbindnervegrowthfactor(NGF).TrkBisinvolvedinthedevelopmentand/ormaintenanceofthenervoussystemandiswidelyexpressed,predominantlyinnervoustissue.TrkBisaheavilyglycosylatedtypeItransmembraneprotein.TheTrkB-Fcchimeracontains13potentialN-linkedglycosylationsites.
BatchNo.Seeproductlabel
Unitsize20µg
OtherNamesTropomyosin-relatedkinasereceptor;BDNF/NT-3growthfactorsreceptor;Neurotrophictyrosinekinasereceptortype2;TrkBtyrosinekinase;GP145-TrkB/GP95-TrkB;Trk-B;Ntrk2;Trkb;TrkB-FcChimera
AccessionQ16620NTRK2_HUMAN;
ProducedinHuman-ADNAsequenceencodingthesignalpeptideandextracellulardomainofhumanTrkB(aminoacids1-428)wasfusedtotheFcregionofhumanIgG1(aminoacids93-330).Thechimericproteinwasexpressedinmodifiedhuman293cells.
MolecularWeightTheTrkB-Fcchimeramigratesasabroadbandbetween90and115kDainSDS-PAGEduetopost-translationalmodifications,inparticularglycosylation.TheunmodifiedTrkB-Fcchimerahasapredictedmolecularmassof71.0kDa.ThemodifiedTrkB-FcchimeraseparatesintoanumberofisoformswithapIbetween4.9and6.7in2DPAGEwhereastheunmodifiedTrkB-FcchimerahasapredictedpIof5.79.
Purity>95%,asdeterminedbySDS-PAGEandvisualizedbysilverstain.
ApplicationsTheTrkB-FcchimeraboundtoproteinAsepharosebeadsisabletopulldownitsligandBDNF.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser.
FormThechimeraconsistsof20-40%carbohydratebyweight.
ReconstitutionItisrecommendedthat0.5mlofsterilephosphate-bufferedsalinebeaddedtothevial.
StorageLyophilizedproductsshouldbestoredat2to8°C.Followingreconstitution,short-termstorageat4°Cisrecommendedandlonger-termstorageofaliquotsat-18to-20°C.Repeatedfreezethawingisnotrecommended.
品牌介绍

Biosensis专注于神经科学领域的抗体和试剂的开发,特别是神经营养因子和神经营养因子受体。 近30年来,Biosensis一直是该领域的全球领航者和OEM供应商。除神经营养因子,我们的神经科学产品组合还被广泛用于神经退行性疾病、神经发育和神经代谢的研究。重点研究领域包括阿尔茨海默氏症(AD)、帕金森氏症(PD)和肌萎缩侧索硬化(ALS)疾病,以及自噬和代谢应激障碍,包括肥胖、代谢综合征的研究、神经免疫学和炎症。

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