商品介绍
| Description | MAP1LC3Bisasubunitofneuronalmicrotubule-associatedMAP1AandMAP1Bproteins,whichareinvolvedinmicrotubuleassemblyandimportantforneurogenesis.MAP1LC3Bisprobablyinvolvedinformationofautophagosomalvacuoles(autophagosomes).SUBCELLULARLOCATION:LC3-I:Cytoplasm.LC3-II:Intracytoplasmicmembrane;lipid-anchor.Cytoplasmicvesicle;autophagosome;autophagosomalmembrane;lipid-anchor.LC3-IIbindstotheautophagicmembranes.TISSUESPECIFICITY:Mostabundantinheart,brain,skeletalmuscleandtestis.Littleexpressionobservedinliver.PTM:TheprecursormoleculeiscleavedbyAPG4B/ATG4BtoformLC3-I.ThisisactivatedbyAPG7L/ATG7,transferredtoATG3andconjugatedtophospholipidtoformLC3-II.SIMILARITY:BelongstotheMAP1LC3family. |
| BatchNo. | Seeproductlabel |
| Unitsize | 100µl |
| Antigen | Asyntheticpeptide(FEQRVEDVRLIC)correspondingtotheN-terminalofhumanMAP1LC3BproteinconjugatedtoBlueCarrierProteinhasbeenusedastheimmunogen.ThepeptideishomologouswiththecorrespondingsequencederivedfrommouseandratMAP1LC3Bprotein. |
| OtherNames | Microtubule-associatedproteins1A/1Blightchain3B;Microtubule-associatedprotein1lightchain3beta;MAP1A/MAP1BLC3B;MAP1A/1Blightchain3B;MAP1lightchain3-likeprotein2;Autophagy-relatedproteinLC3B;Autophagy-relatedubiquitin-likemodifierLC3B;APG8b;MAP-1LC3B;MAP1LC3B;MAP1ALC3; |
| Accession | MLP3B_HUMAN MLP3B_MOUSE MLP3B_RAT |
| Producedin | Rabbit |
| Purity | Wholeserum |
| Applications | IHC,immunofluorescence,WB.Adilutionof1:100to1:1000dilutionisrecommendedfortheseapplications.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser. |
| Specificity | IHC,WBandELISAconfirmedthespecificityforMAP1LC3B. |
| Cross-reactivity | Human,rat.Otherspeciesnotyettested. |
| Form | Lyophilised |
| Reconstitution | Reconstitutein100µlofsterilewater.Centrifugetoremoveanyinsolublematerial. |
| Storage | Afterreconstitutionkeepaliquotsat-20ºCforahigherstABIlity,andat4ºCwithanappropriateantibacterialagent.Glycerol(1:1)maybeaddedforanadditionalstability.Avoidrepetitivefreeze/thawcycles. |
| ExpiryDate | 12monthsafterpurchase |
| SpecificReferences | TheronAEetal.(2013)Molecularcrosstalkbetweenapoptosisandautophagyinducedbyanovel2-methoxyestrADIolanalogueincervicaladenocarcinomacells.CancerCellInt.2013Aug27;13(1):87. PilchowskiR.etal.(2011)SpecificProteinPatternsCharacterizeMetastaticPotentialofAdvancedBladderCancer.JUrol.2011Jun16. |
| GeneralReferences | 1.DifilippantonioS,etal.Eur.J.Cancer39:1936-1947(2003). 2.YangY.-S,etal.Endocr.Relat.Cancer10:621-627(2003). 3.HeH,etal.J.Biol.Chem.278:29278-29287(2003). 4.OtaT,etal.Nat.Genet.36:40-45(2004). 5.TanidaI,etal.J.Biol.Chem.279:36268-36276(2004). 6.TanidaI,etal.J.Biol.Chem.279:47704-47710(2004). 7.TanidaI,etal.Int.J.Biochem.CellBiol.36:2503-2518(2004). |
品牌介绍
Biosensis专注于神经科学领域的抗体和试剂的开发，特别是神经营养因子和神经营养因子受体。 近30年来，Biosensis一直是该领域的全球领航者和OEM供应商。除神经营养因子，我们的神经科学产品组合还被广泛用于神经退行性疾病、神经发育和神经代谢的研究。重点研究领域包括阿尔茨海默氏症（AD）、帕金森氏症（PD）和肌萎缩侧索硬化（ALS）疾病，以及自噬和代谢应激障碍，包括肥胖、代谢综合征的研究、神经免疫学和炎症。
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