Description | Ubiquitin-likemodifierinvolvedinintra-Golgitraffic.Modulatesintra-GolgitransportthroughcouplingbetweenNSFactivityandSNAREsactivation.ItfirststimulatestheATPaseactivityofNSFwhichinturnstimulatestheassociationwithGOSR1(Bysimilarity).Involvedinautophagy.PlaysaroleinmitophagywhichcontributestoregulatemitochondrialquantityandqualitybyeliminatingthemitochondriatoabasalleveltofulfillcellularenergyrequirementsandpreventingexcessROSproduction.WhereasLC3sareinvolvedinelongationofthephagophoremembrane,theGABARAP/GATE-16subfamilyisessentialforalaterstageinautophagosomematuration.SUBUNIT:Monomer.SUBCELLULARLOCATION:Golgiapparatus.TISSUESPECIFICITY:Ubiquitous.Expressedathighlevelsinthebrain,heart,prostate,ovary,spleenandskeletalmuscle.Expressedatverylowlevelsinlung,thymusandsmallintestine.SIMILARITY:BelongstotheMAP1LC3family.ESTIMATEDMOLECULARWEIGHT:13.667kDa |
BatchNo. | Seeproductlabel. |
Unitsize | 100µg |
Antigen | Asyntheticpeptide(C-VESAKIRAKYP,aa:16-26)ofhumanGABARAPL2proteinhasbeenusedastheimmunogen.Thesequenceishomologouswithmouse,ratandbovineformofGABARAPL2. |
Clone | BS392 |
OtherNames | Gamma-aminobutyricacidreceptor-associatedprotein-like2;GABA(A)receptor-associatedprotein-like2;Gangliosideexpressionfactor2;GEF-2;Generalproteintransportfactorp16;MAP1lightchain3-relatedprotein;GABARAPL2;FLC3A;GEF2 |
Accession | GBRL2_HUMAN GBRL2_MOUSE GBRL2_RAT |
Producedin | Mouse |
MolecularWeight | 14kDa |
Purity | ProteinGpurifiedmouseIgG |
Applications | FlowCytometry(2µg/10^6cells).Otherapplicationsnotyettested.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser. |
Specificity | Human |
Cross-reactivity | Notyettested.Antibodyisexpectedtodetectmouse,ratandbovineGABARAPL2proteindueto100%aminoacidsequencehomology. |
Form | LyophilisedfromasolutioncontainingPBSbufferpH7.4with3%trehalose,withoutpreservatives. |
Appearance | Whitepowder |
Reconstitution | Spinvialbrieflybeforeopening.Reconstitutein100µLofsterilewater.Centrifugetoremoveanyinsolublematerial.Finalbuffercontainsnopreservatives. |
Storage | Afterreconstitutiondivideintoaliquotsandstoreat-20ºCforahigherstABIlity.Antibodycontainsnopreservatives.Storeat4ºCwithanappropriateantibacterialagent.Usesterilemethods.HighestpurityGlycerol(1:1)maybeaddedforanadditionalstabilitywhenstoredatrefrigeratedorfreezingtemperatures.Avoidrepetitivefreeze/thawcycles. |
ExpiryDate | 12monthsafterpurchaseifunopened. |
References | 1.OkazakiN.etal.BrainRes.Mol.BrainRes.85:1-12(2000) 2.XinY.etal.Genomics74:408-413(2001) 3.TheMGCProjectTeam.GenomeRes.14:2121-2127(2004) |
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