产品编号：BEK-2237-2P
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商品介绍
Finda1platesizeofthisproducthere.Enquireaboutbulkdiscountsfortenormoreplates,atsales@Biosensis.com| Description | TheBiosensisproBDNFRapidTMenzyme-linkedimmunosorbentassay(ELISA)KitisasandwichELISAthatallowsthespecific,fastandreliablequantificationofproBDNFinlessthan4hoursincellculturesupernatants,humanserumandEDTA-plasmaonlyifusedasdirected.Pleaserefertothekitprotocolforspecificuseinstructionsforeachsubstrateapplication,inparticularhumanbloodsamples. | ThisELISAkitconsistsofapre-coatedmonoclonalanti-proBDNFcaptureantibody,abiotinylatedanti-matureBDNFdetectionantibodyandhorserADIshperoxidase(HRP)-conjugatedstreptavidin.Theadditionofasubstrate(3,3,5,5-tetramethylbenzidine,TMB)yieldsacoloredreactionproductwhichisdirectlyproportionaltotheconcentrationofproBDNFpresentinsamplesandproteinstandards.AproBDNFpositivecontrol(QCsample)isprovidedtoassureconsistentassayperformance. ThisproBDNFELISAkitemploysarecombinant,cleavage-resistanthumanproBDNFstandardproducedinmammaliancellsbyBiosensisandvalidatedagainstexternallyavailableproBDNFproteins. NotethataccurateproBDNFquantificationinhumanserumandEDTA-plasmarequirestheadditionofHeterophilicAntibodyBlockerBL-004-500providedinthekit,andavailableforpurchaseseparately. ThisELISAkithasnotbeentestedforotherapplications.Ithasbeenconfiguredforresearchuseonlyandisnottobeusedfordiagnosticorclinicalprocedures. Relatedproducts | BL-004-500,Heterophilicantibodyblocker:SamplediluentadditiveforaccuratequantificationofproBDNFinhumanserumandEDTA-plasma. | BEK-2211-2P:MatureBDNFRapidELISAKit BatchNo. | Refertotheproductlabel. | Antigen | BDNFbelongstotheneurotrophinfamilyandregulatesthesurvivalanddifferentiationofneuronsduringdevelopment.ThealterationsinBDNFexpressioninducedbyvariouskindsofbraininsultincludingstress,ischemia,seizureactivityandhypoglycemia,maycontributetosomepathologiessuchasdepression,epilepsy,Alzheimer"sDisease,andParkinson"sdisease.FUNCTION:BDNFpromotesthesurvivalofneuronalpopulationsthatarealllocatedeitherinthecentralnervoussystemordirectlyconnectedtoit.BDNFisalsoamajorregulatorofsynaptictransmissionandplasticityatadultsynapsesinmanyregionsoftheCNS.TheversatilityofBDNFisemphasizedbyitscontributiontoarangeofadaptiveneuronalresponsesincludinglong-termpotentiation(LTP),long-termdepression(LTD),certainformsofshort-termsynapticplasticity,aswellashomeostaticregulationofintrinsicneuronalexcitABIlity.SUBUNIT:Monomersandhomodimers.BindstoNTRK2/TRKB.SUBCELLULARLOCATION:Secretedprotein.PostTranslationModification(PTM):ThepropeptideisN-glycosylatedandglycosulfated.PTM:ConvertedintomatureBDNFbyplasmin(PLG).DISEASE:DefectsinBDNFareacauseofcongenitalcentralhypoventilationsyndrome(CCHS);alsoknownascongenitalfailureofautonomiccontrolorOndinecurse.CCHSisararedisordercharacterizedbyabnormalcontrolofrespirationintheabsenceofneuromuscularorlungdisease,oranidentifiablebrainstemlesion.AdeficiencyinautonomiccontrolofrespirationresultsininadequateornegligIBLeventilatoryandarousalresponsestohypercapniaandhypoxemia.CCHSisfrequentlycomplicatedwithneurocristopathiessuchasHirschsprungdiseasethatoccursinabout16%ofCCHScases.SIMILARITY:BelongstotheNGF-betafamily. | OtherNames | Brain-derivedneurotrophicfactor;BDNF;Abrineurin | Accession | P23560BDNF_HUMAN; | Specificity | HumanproBDNF.ThecaptureantibodyusedinthisELISAkitbindstoanepitopewithinthepro-domainofproBDNF.Thus,thisELISAdetectsthefulllengthformofproBDNFanddoesnotquantifymatureBDNF.WhetherthisELISAkitcandetecttruncatedBDNFisunknownatpresent. | Cross-reactivity | MatureBDNFcross-reactivitywasassessedbyspiking28kDamatureBDNFproteinobtainedfromWHO(www.NIBSC.org)intoa1/5dilutedhumanserumsampleat5ng/mL,whichrepresentsaBDNFconcentrationlevelof25ng/mLinundiluted,normalhumanserum.Cross-reactivityofmatureBDNFwas< 0.3% (w/v), or < 0.1% in molar concentration. | Theassayantibodiesdonotcross-reactwithnervegrowthfactor(NGF),neurotrophin-3(NT-3)orNT-4/5. Speciescross-reactivityhasnotyetbeendetermined. Storage | Storeat4°C | ExpiryDate | 12monthsfrompurchase. | Kitcomponents | TheELISAkitboxcontains2x96pre-coatedstripplate,proteinstandards,QCsample,detectionreagents,heterophilicantibodyblocker,washandsamplebuffersanddetailedprotocols. | Range | 15.6-1000pg/mL | Sensitivity | Typicallimitofdetection(LOD)forproBDNFis6pg/mLdeterminedas150%oftheblankvalue. | Kitprotocol |  BEK-2237_as_at_December2017.pdfMSDS | MSDS_Rapid_ELISA_as_at_Aug2017.pdf品牌介绍
Biosensis专注于神经科学领域的抗体和试剂的开发，特别是神经营养因子和神经营养因子受体。 近30年来，Biosensis一直是该领域的全球领航者和OEM供应商。除神经营养因子，我们的神经科学产品组合还被广泛用于神经退行性疾病、神经发育和神经代谢的研究。重点研究领域包括阿尔茨海默氏症（AD）、帕金森氏症（PD）和肌萎缩侧索硬化（ALS）疾病，以及自噬和代谢应激障碍，包括肥胖、代谢综合征的研究、神经免疫学和炎症。 公司介绍
产品分类
TR-200-BG
PE-1243-50
Antibody Kits
PE-1246-5
TR-100-BG
S-1754-500
Neurotrophic Factors
Diabetes & Obesity
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PE-1239-5
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2 Plate ELISA kits
M-1763-100-FT
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PE-1239-2
PE-1242-5
M-1249-100
Neurotrophic Factor Receptors
Cell Cycle Regulators
S-1759-100
PE-1606-100
PE-1762-100
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PE-019-100
PE-1241-5
PE-003-100
1 Plate ELISA kits
BL-003-1000
PE-1246-2
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PE-1253-100
TR-100-FJ
BL-005-500
Neuroendocrine
M-1728-100
DNA Damage & Repair
PE-001-100
PE-1608-1
TR-400-AG
PE-1243-25
Cell Markers
PE-1608-5
TR-100-FJT
Autophagy
PE-1242-2
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Tag Antibodies
BL-004-500
PE-019-25
PE-1608-10
BL-002-1250
Receptor Body Chimeras
Signalling & Transcription
Matrix & Adhesion Molecules
BL-001-1250
Cancer
PE-019-500
Stem Cells
Junction Proteins
TR-300-AG
Apoptosis
PE-1252-100
Growth Factors
Development
Alzheimer\'s / Parkinson\'s
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