Description | TranscriptionfactorHES-1isatranscriptionalrepressorofgenesthatrequireabasichelix-loop-helixproteinfortheirtranscription.Itneedstoformacomplexwithacorepressorprotein(Groucho)torepresstranscription.TranscriptionfactorHES-1hasaparticulartypeofbasicdomainwhichcontainsahelix-interruptingproline,thatbindstotheN-box(CACNAG)ratherthanthecanonicalE-box(CANNTG).ItalsoconsistsofaC-terminalWRPWmotifthatisnecessaryfortheinteractionwithGroucho.Itlocalisestothenucleus. |
BatchNo. | Refertoproductlabel |
Unitsize | 100µg |
Antigen | PartialrecombinantproteinofhumanTranscriptionfactorHES-1(aa36to143)withaGSTtag. |
Clone | 4D9 |
OtherNames | Hairyandenhancerofsplit1;Hairy-like;HHL;Hairyhomolog;HES1;HL;HRY |
Accession | HES1_HUMAN |
Producedin | Mouse |
Purity | ProteinGpurifiedimmunoglobulin |
Applications | ThisantibodyisrecommendedforWB,andsandwichELISA.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser. |
Specificity | SpecificityhasbeenconfirmedbyWBanddirectELISAagainsttheantigen. |
Cross-reactivity | Human.Otherspecieshavenotbeentested. |
Blastit | Toseethesharedidentitybetweendifferentspeciesorotherproteins,followthelinkintheAccessionfield,selectthesequencethatyouareinterestedinandcopyandpasteitHEREandblast/formatit. |
Form | LyophilisedfromPBSpH7.3 |
Reconstitution | Reconstitutein100µlofsterilewater.Centrifugetoremoveanyinsolublematerial. |
Storage | Afterreconstitutionkeepaliquotsat-20ºCforhigherstABIlityorat4ºCwithanappropriateantibacterialagent.Glycerol(1:1)maybeaddedforadditionalstability.Avoidrepetitivefreeze/thawcycles. |
ExpiryDate | 12monthsafterpurchase |
Biosensis专注于神经科学领域的抗体和试剂的开发,特别是神经营养因子和神经营养因子受体。 近30年来,Biosensis一直是该领域的全球领航者和OEM供应商。除神经营养因子,我们的神经科学产品组合还被广泛用于神经退行性疾病、神经发育和神经代谢的研究。重点研究领域包括阿尔茨海默氏症(AD)、帕金森氏症(PD)和肌萎缩侧索硬化(ALS)疾病,以及自噬和代谢应激障碍,包括肥胖、代谢综合征的研究、神经免疫学和炎症。