Description | FUNCTION:Onegapjunctionconsistsofaclusterofcloselypackedpairsoftransmembranechannels,theconnexons,throughwhichmaterialsoflowmolecularweightdiffusefromonecelltoaneighboringcell.SUBUNIT:Aconnexoniscomposedofahexamerofconnexins.SUBCELLULARLOCATION:Membrane;multi-passmembraneprotein.TISSUESPECIFICITY:Highlyexpressedinlung.SIMILARITY:Belongstotheconnexinfamily.Alpha-type(groupII)subfamily. |
BatchNo. | Seeproductlabel |
Unitsize | 100µL |
Antigen | Asyntheticpeptide(SLVQGLTPPPDFNQCLK)aspartofratConnexin-40protein(aa:253-269)conjugatedtodiphtheriatoxoidhasbeenusedastheimmunogen. |
OtherNames | Gapjunctionalpha-5protein;Cx40;Gja5;Cxn-40 |
Accession | CXA5_RAT |
Producedin | Sheep |
Purity | Wholeserum |
Applications | Immunohistochemistry,Westernblot.Adilutionof1:10,000to1:50,000isrecommendedfortheseapplications.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser. |
Cross-reactivity | ThisantiserumrecognisesConnexin-40inrat. |
Blastit | Ifyouwouldliketousethisproductinanotherspeciesotherthanthosespecifiedhere,ortoseethesharedidentitybetweentheimmunogenusedhereindifferentspeicesand/orothermolecules,simplycopytheimmunogen(fromtheImmunogenfield)andpasteitHEREandblast/formatit.Notethat,antiseraraisedagainstsyntheticpeptidesarequiteoftenveryspecificforthatpeptideie,onlyonesingleaminoaciddifferencemaybeenoughtorestrictthespecificitytoaparticularmolecule.Regardless,youcanalwayscontactusifyouneedassistancewiththis. |
Form | Lyophilised |
Reconstitution | Reconstitutein100µlofsterilewater.Centrifugetoremoveanyinsolublematerial. |
Storage | Afterreconstitutionkeepaliquotsat-20ºCforahigherstABIlity,andat4ºCwithanappropriateantibacterialagent.Glycerol(1:1)maybeaddedforanadditionalstability.Avoidrepetitivefreeze/thawcycles. |
ExpiryDate | 12monthsafterpurchase |
References | 1.Rummeryetal.(2002).ATVB22,1429-1432 |
Biosensis专注于神经科学领域的抗体和试剂的开发,特别是神经营养因子和神经营养因子受体。 近30年来,Biosensis一直是该领域的全球领航者和OEM供应商。除神经营养因子,我们的神经科学产品组合还被广泛用于神经退行性疾病、神经发育和神经代谢的研究。重点研究领域包括阿尔茨海默氏症(AD)、帕金森氏症(PD)和肌萎缩侧索硬化(ALS)疾病,以及自噬和代谢应激障碍,包括肥胖、代谢综合征的研究、神经免疫学和炎症。