商品介绍
| Description | FUNCTION:Onegapjunctionconsistsofaclusterofcloselypackedpairsoftransmembranechannels,theconnexons,throughwhichmaterialsoflowmolecularweightdiffusefromonecelltoaneighboringcell.Connexin-37mayalsomediatehyperexcitABIlityfollowinnerveinjury.SUBUNIT:Aconnexoniscomposedofahexamerofconnexins.SUBCELLULARLOCATION:Membrane;multi-passmembraneprotein.TISSUESPECIFICITY:Highlyexpressedinlung.SIMILARITY:Belongstotheconnexinfamily.Alpha-type(groupII)subfamily. |
| BatchNo. | Seeproductlabel |
| Unitsize | 100µl |
| Antigen | Asyntheticpeptide(YLPMGEGPSSPPCPTY)aspartofratConnexin-37protein(aa:265-280)conjugatedtodiphtheriatoxoid |
| OtherNames | Gapjunctionalpha-4protein;Cx37;Gja4;Cxn-37 |
| Accession | CXA4_RAT |
| Producedin | Sheep |
| Purity | Wholeserum |
| Applications | Immunohistochemistry,Westernblot.Adilutionof1:1000to1:5000isrecommendedforIHCand1:5000to1:10000forwesternblot.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser. |
| Specificity | WesternblottingofcellmembarnesofCOScellstransientlytransfectedwithCDNAencodingConnexin-37showstwobandsofmolecularweight36and37kDawhichareabolishedbypreincubationwiththeimmunisingpeptide.Nosuchbandsaredetectedinwesternblotsofmembranesfromnon-transfectedcellsorcellstransfectedwithcDNAencodingConnexin-40,Connexin-43orConnexin-45. |
| Cross-reactivity | ThisantiserumrecognisesratandmouseConnexin-37protein. |
| Blastit | Ifyouwouldliketousethisproductinanotherspeciesotherthanthosespecifiedhere,ortoseethesharedidentitybetweentheimmunogenusedhereindifferentspeicesand/orothermolecules,simplycopytheimmunogen(fromtheImmunogenfield)andpasteitHEREandblast/formatit.Notethat,antiseraraisedagainstsyntheticpeptidesarequiteoftenveryspecificforthatpeptideie,onlyonesingleaminoaciddifferencemaybeenoughtorestrictthespecificitytoaparticularmolecule.Regardless,youcanalwayscontactusifyouneedassistancewiththis. |
| Form | Lyophilised |
| Reconstitution | Reconstitutein100µlofsterilewater.Centrifugetoremoveanyinsolublematerial. |
| Storage | Afterreconstitutionkeepaliquotsat-20ºCforahigherstability,andat4ºCwithanappropriateantibacterialagent.Glycerol(1:1)maybeaddedforanadditionalstability.Avoidrepetitivefreeze/thawcycles. |
| ExpiryDate | 12monthsafterpurchase |
| References | 1.Rummeryetal.(2002).ATVB22,1429-1432 |
品牌介绍
Biosensis专注于神经科学领域的抗体和试剂的开发，特别是神经营养因子和神经营养因子受体。 近30年来，Biosensis一直是该领域的全球领航者和OEM供应商。除神经营养因子，我们的神经科学产品组合还被广泛用于神经退行性疾病、神经发育和神经代谢的研究。重点研究领域包括阿尔茨海默氏症（AD）、帕金森氏症（PD）和肌萎缩侧索硬化（ALS）疾病，以及自噬和代谢应激障碍，包括肥胖、代谢综合征的研究、神经免疫学和炎症。
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