Description | Sodiumchannelproteintype8subunitalphamediatesthevoltage-dependentsodiumionpermeABIlityofexcitablemembranes.Adoptingopenedorclosedconformationinresponsetothevoltagedifferenceacrossthemembrane,theproteinformsasodium-selectivechannelthroughwhichNaionsmaypassinaccordancewiththeirelectRochemicalgrADIent.Itisamulti-passtransmembraneproteinthatiswidelyexpressedinneuronsofthecentralandperipheralnervoussystem.Therearefournamedisoforms.Thesequencecontains4internalrepeats,eachwith5hydrophobicsegments(S1,S2,S3,S5,S6)andonepositivelychargedsegment,S4. SegmentsS4arethoughttobethevoltage-sensorsandarecharacterisedbyaseriesofpositivelychargedaminoacidsateverythirdposition. |
BatchNo. | Seeproductlabel |
Unitsize | 100µg |
Antigen | PartialrecombinanthumanSodiumchannelproteintype8subunitalpha(aminoacids1854-1951)withaGSTtag. |
Clone | 4G7 |
OtherNames | SodiumchannelproteintypeVIIIsubunitalpha;Voltage-gatedsodiumchannelsubunitalphaNav1.6;SCN8A;MED |
Accession | SCN8A_HUMAN |
Producedin | Mouse |
Purity | ProteinGpurifiedimmunoglobulin |
Applications | ThisantibodyisrecommendedforWB,immunofluorescenceanddirectELISA.Therecommendeddilutionforthisantibodyis10µg/mlforimmunofluorescence.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser. |
Specificity | SpecificityhasbeenconfirmedbyWBanddirectELISAagainsttheantigen. |
Cross-reactivity | Human,mouseandrat.Otherspecieshavenotbeentested. |
Blastit | Toseethesharedidentitybetweendifferentspeciesorotherproteins,followthelinkintheAccessionfield,selectthesequencethatyouareinterestedinandcopyandpasteitHEREandblast/formatit. |
Form | LyophilisedfromPBSpH7.2 |
Reconstitution | Reconstitutein100µlofsterilewater.Centrifugetoremoveanyinsolublematerial. |
Storage | Afterreconstitutionkeepaliquotsat-20ºCforhigherstabilityorat4ºCwithanappropriateantibacterialagent.Glycerol(1:1)maybeaddedforadditionalstability.Avoidrepetitivefreeze/thawcycles. |
ExpiryDate | 12monthsafterpurchase |
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