Description | FUNCTION:Associatesspecificallywithhuntingtin.Thisbindingisenhancedbyanexpandedpolyglutaminerepeat.ALTERNATIVEPRODUCTS:2namedisoformsproducedbyalternativesplicing.TISSUESPECIFICITY:Inthebrain,especiallyintheolfactorybulbandinthebrainstem.Nodetectableexpressioninperipheraltissuessuchaslung,testis,spleen,andsmallintestine.SIMILARITY:Contains1HAP1N-terminaldomain. |
BatchNo. | Seeproductlabel |
Unitsize | 100µl |
Antigen | RecombinantratHAP-1 |
OtherNames | Huntingtin-associatedprotein1;HAP1 |
Accession | HAP1_RAT |
Producedin | Rabbit |
Purity | Wholeserum |
Applications | IHC.Adilutionof1:500to1:3000isrecommendedforthisapplication.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser. |
Specificity | SpecificityforHAP-1wasconfirmedbyIHC. |
Cross-reactivity | ThisantiserumisknowntoreactwithratHAP-1.Otherspecieshavenotyetbeentested. |
Blastit | IfyouwouldliketoseethesharedidentitybetweendifferentspeciesorotherproteinsfollowthelinkinAccessionfield,selectthenthesequence(makesurethatyouareselectingthesequencethatyouareinterestedin,asthesequencemaybetheprecursorratherthanthematureproteinforexample)andcopyandpasteitHEREandblast/formatit. |
Form | Lyophilised |
Reconstitution | Reconstitutein100µlofsterilewater.Centrifugetoremoveanyinsolublematerial. |
Storage | Afterreconstitutionkeepaliquotsat-20ºCforahigherstABIlity,andat4ºCwithanappropriateantibacterialagent.Glycerol(1:1)maybeaddedforanadditionalstability.Avoidrepetitivefreeze/thawcycles. |
References | 1.Zhou,H.etal.(2003).J.CellBiol.163(1):109-118. 2.Fusco,F.R.etal.(2003).Eur.J.Neurosci.18:1-10. 3.Pardo,R.etal.(2006).J.Neurosci.26(5):1635-1645. 4.Harper,S.Q.etal.(2005).Proc.Nat.Acad.Sci.(USA)102:5820-5825. 5.Qin,Z.etal.(2004).J.Neurosci.24(1):269-281. 6.Tang,T.S.etal.(2003).Neuron39(2):227-239. |
Biosensis专注于神经科学领域的抗体和试剂的开发,特别是神经营养因子和神经营养因子受体。 近30年来,Biosensis一直是该领域的全球领航者和OEM供应商。除神经营养因子,我们的神经科学产品组合还被广泛用于神经退行性疾病、神经发育和神经代谢的研究。重点研究领域包括阿尔茨海默氏症(AD)、帕金森氏症(PD)和肌萎缩侧索硬化(ALS)疾病,以及自噬和代谢应激障碍,包括肥胖、代谢综合征的研究、神经免疫学和炎症。