Description | FUNCTION:Canmediateactivationofc-JunandNF-kappa-B.Maypromotecaspase-independentcelldeath.Isoform2andisoform3mayactasdecoyreceptors.SUBUNIT:AssociateswithTRAF1,TRAF2,TRAF3andTRAF5.SUBCELLULARLOCATION:Isoform1,isoform3,isoform4:Cellmembrane;single-passtypeImembraneprotein(Probable).Isoform2:Secretedprotein(Probable).ALTERNATIVEPRODUCTS:4namedisoformsproducedbyalternativesplicing.TISSUESPECIFICITY:Highlyexpressedinadultbrain,andinembryosfromday11-17,butnotearlier.Detectedinembryonicbrainandepithelium,andatlowerlevelsinadultheart,lungandliver.Inneonatalmice,mainlyinhairfolliclesandneuron-likecellsinthecerebellum,butnotintheskinepidermis.Isoform3wasfoundinembryonicday17.5skinbutnotinbrainandliver.SIMILARITY:Contains3TNFR-Cysrepeats. |
BatchNo. | Seeproductlabel |
Unitsize | 100µl |
Antigen | Asyntheticpeptide(CRPHRFKEDWGFQK)aspartofmouseTROYprotein(aa:75-88)conjugatedtotheimmunogenicproteinBlueCarrierProtein |
OtherNames | Tumornecrosisfactorreceptorsuperfamilymember19;TNFRSF19;ToxicityandJNKinducer;TRADE |
Accession | TROY_MOUSE |
Producedin | Rabbit |
Purity | Wholeserum |
Applications | IHC.Recommendedtobeusedatadilutionof1:500to1:2000forimmunohistochemistry.Thisantiserumhasnotyetbeentestedforwesternblot.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser. |
Specificity | SpecificityforTROYwasconfirmedbyIHC. |
Cross-reactivity | ThisantiserumisknowntoreactwithratTROY.Reactivitywithotherspecieshavenotyetbeentested. |
Blastit | Ifyouwouldliketousethisproductinanotherspeciesotherthanthosespecifiedhere,ortoseethesharedIDbetweentheimmunogenusedhereindifferentspeicesand/orothermolecules,simplycopytheimmunogen(fromtheImmunogenfield)andpasteitHEREandblast/formatit.Notethat,antiseraraisedagainstsyntheticpeptidesarequiteoftenveryspecificforthatpeptideie,onlyonesingleaminoaciddifferencemaybeenoughtorestrictthespecificitytoaparticularmolecule.Regardless,youcanalwayscontactusifyouneedassistancewiththis. |
Form | Lyophilised |
Reconstitution | Reconstitutein100µlofsterilewater.Centrifugetoremoveanyinsolublematerial. |
Storage | Afterreconstitutionkeepaliquotsat-20°CforahigherstABIlity,andat4°Cwithanappropriateantibacterialagent.Glycerol(1:1)maybeaddedforanadditionalstability.Avoidrepetitivefreeze/thawcycles. |
References | 1.Hisaoka,T.(2004).Glia45:313-324. 2.Hisaoka,T.(2006b).EurJNeurosci23:3149-3160. 3.Kojima,T.(2000).JBiolChem275:20742-20747. |
Biosensis专注于神经科学领域的抗体和试剂的开发,特别是神经营养因子和神经营养因子受体。 近30年来,Biosensis一直是该领域的全球领航者和OEM供应商。除神经营养因子,我们的神经科学产品组合还被广泛用于神经退行性疾病、神经发育和神经代谢的研究。重点研究领域包括阿尔茨海默氏症(AD)、帕金森氏症(PD)和肌萎缩侧索硬化(ALS)疾病,以及自噬和代谢应激障碍,包括肥胖、代谢综合征的研究、神经免疫学和炎症。