产品编号：M-1692-100
市 场 价：¥5940.00
场 地：美国(厂家直采)
联系QQ：1570468124
电话号码：4000-520-616
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info@ebiomall.com
商品介绍
| Description | Theheatshockproteinswerediscovered,asthenamesuggests,sincetheyareheavilyupregulatedwhencellsarestressedbytemperaturesabovethenormalphysiologicalrange.Theyareexpressedinunstressedcellsalsoandhaveanormalfunctionaschaperones,helpingotherproteinstofoldcorrectly,andarerequiredinmuchgreateramountsifthecellortissueisstressedbyheat.Theincreasedlevelsaregeneratedtranscriptionallyundertheinfluenceofapowerfultranscriptionfactor,theheatshockfactor1(HSF1).ThedifferentheatshockproteinswereoriginallynamedbasedontheirSDS-PAGEmobility,soHSP27hasanapparentmolecularweightof27kDa.Itisanabundantproteinevenundernon-stressconditionsandfrequentlyshowsupasamajorspoton2dimensionalgelsofcellsortissues.Itisknowntoassociatewithavarietyofotherproteinssuchasactin,intermediatefilamentsubunitsandubiquitinandisfoundbothinthecytoplasmandthenucleusofcells.HSP27canbecomeheavilyphosphorylatedundertheinfluenceofmultipleproteinkinasesparticularlyasaresultofactivationofthep38/SAPKpathway.Upregulationofthisproteinisprotectiveagainstneurodegenerativediseasesatleastincertainmousemodels(1).PointmutationsintheHSP27geneareassociatedwithtwoneurologicaldiseases,Charcot-Marie-Toothdiseasetype2FanddistalhereditarymotorneuropathyIIB(2).Thesediseasesareassociatedwithaxonallossapparentlyfollowingdefectsinthetransportofneurofilaments. |
| Unitsize | 100uL |
| Antigen | HSP27 |
| Isotype | IgG1 |
| Producedin | Mouse |
| Purity | IgG |
| Applications | WesternBlotting(WB)andImmunocytochemistry(IC).Adilutionof1:5,000-1:10,000isrecommendedforWB.Adilutionof1:500-1:1,000isrecommendedforIC.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser. |
| Specificity | Theantibodyreactswitha27kDabandbyWesternblotonacrudeextractfromHeLacells.Ithasalsobeenusedsuccessfullyforimmunocytochemistry. |
| SpeciesAgainst | Human,rat,mouse,porcineandbovine.Itisexpectedthatitwillworkonothermammaltissues. |
| AntibodyAgainst | HeatShockProtein27(HSP27) |
| Form | Lyophilisedwith5%trehalose |
| Appearance | Whitepowder |
| Reconstitution | Reconstituteinsteriledistilledwater.Centrifugetoremoveanyinsolublematerial. |
| Storage | Afterreconstitutionoflyophilisedantibody,aliquotandstoreat-20°CforahigherstABIlity.Avoidfreeze-thawcycles. |
| ExpiryDate | 12monthsafterpurchase |
| GeneralReferences | 1.Wyttenbach,Aetal.Heatshockprotein27preventscellularpolyglutaminetoxicityandsuppressestheincreaseofreactiveoxygenspeciescausedbyhuntingtin.Hum.Molec.Genet.11:1137-1151(2002).2.Evgrafov,OVetal.Mutantsmallheat-shockprotein27causesaxonalCharcot-Marie-Toothdiseaseanddistalhereditarymotorneuropathy.NatureGenet.36:602-606(2004). |
品牌介绍
Biosensis专注于神经科学领域的抗体和试剂的开发，特别是神经营养因子和神经营养因子受体。 近30年来，Biosensis一直是该领域的全球领航者和OEM供应商。除神经营养因子，我们的神经科学产品组合还被广泛用于神经退行性疾病、神经发育和神经代谢的研究。重点研究领域包括阿尔茨海默氏症（AD）、帕金森氏症（PD）和肌萎缩侧索硬化（ALS）疾病，以及自噬和代谢应激障碍，包括肥胖、代谢综合征的研究、神经免疫学和炎症。
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