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主营:抗体类、生化类试剂、ELISA试剂盒、组织染色细胞可视化试剂、针对神经科学和细胞疾病研究产品和纯化蛋白等
℡ 4000-520-616
℡ 4000-520-616
Biosensis/Recombinant Human CNTF/PE-003-100/100 µg
产品编号:PE-003-100
市  场 价:¥4740.00
场      地:美国(厂家直采)
产品分类: 生化试剂>其他>其他试剂>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$237.00
品      牌: Biosensis
公      司:Biosensis
公司分类:
Biosensis/Recombinant Human CNTF/PE-003-100/100 µg
商品介绍
DescriptionCNTFisasurvivalpromotingfactorfordifferenttypesofneuronsinvitroandinvivo.TheessentialstructuralfeaturesfortheBIOLOGicalfunctionofhumanCNTFwereinvestigatedbyThier,M.etal.Theyshowedthatdeletionof14N-terminaland18C-terminalaminoacidssignificantlyincreasedbioactivitycomparedtowild-typeCNTF.FUNCTION:CNTFisasurvivalfactorforvariousneuronalcelltypes.Seemstopreventthedegenerationofmotoraxonsafteraxotomy.SUBUNIT:Homodimer.SUBCELLULARLOCATION:Cytoplasm.TISSUESPECIFICITY:Nervoussystem.PHARMACEUTICAL:CNTFisbeingtestedunderthenameAxokinebyRegeneronPharmaceuticalsfortreatmentofhumanmotorneurondiseases,suchasamyotrophiclateralsclerosis(ALS).Asitinducessubstantialweightloss,preferentiallyoffatasopposedtoleanbodymass,itisbeingusedforobesitytreatment.SIMILARITY:BelongstotheCNTFfamily.
BatchNo.Seeproductlabel
Unitsize100µg
SequenceHistidine-V5epitopefusedtohumanCNTF(aa:15-200)MRGSHHHHHHGMASMTGGQQMGRDLYDDDDKDPTLDLCSRSIWLARKIRSDLTALTESYVKHQGLNKNINLDSADGMPVASTDQWSELTEAERLQENLQAYRTFHVLLARLLEDQQVHFTPTEGDFHQAIHTLLLQVAAFAYQIEELMILLEYKIPRNEADGMPINVGDGGLFEKKLWGLKVLQELSQWTVRSIHDLRFISSHQTGIPARGSHYIANNKKM
OtherNamesCiliaryNeuroTrophicFactor
AccessionCNTF_HUMAN
ProducedinE.coli
MolecularWeight22.8kDa
Purity95%bySDS-PAGE
Biol.activityIncreasedsurvivalpromotingactivityonneurons
FormLyophilised
ReconstitutionReconstitutethefreeze-driedCNTFproteininthebufferofchoice,forexamplePBS.
StorageAliquotandkeepat-20°Cforlong-termstorage.Forshorttermkeepat4°C.Avoidrepetitivefreeze/thawcycles.
SpecificReferencesWilliamsECetal.(2014)MutantastrocytesdifferentiatedfromRettsyndromepatients-specificiPSCshaveadverseeffectsonwild-typeneurons.HumMolGenet.2014Jun1;23(11):2968-80.
GeneralReferences1.Lin,L.F.etal(1989)Science246,1023-5
2.Stockli,K.A.etal(1991)JCellBiol115,447-59
3.Saggio,I.etal(1995)EmboJ14,3045-54
4.Hermann,D.M.etal(2001)NeurobiolDis8,655-66
5.Thier,M.etal(1995)JNeurosciRes40,826-35
品牌介绍

Biosensis专注于神经科学领域的抗体和试剂的开发,特别是神经营养因子和神经营养因子受体。 近30年来,Biosensis一直是该领域的全球领航者和OEM供应商。除神经营养因子,我们的神经科学产品组合还被广泛用于神经退行性疾病、神经发育和神经代谢的研究。重点研究领域包括阿尔茨海默氏症(AD)、帕金森氏症(PD)和肌萎缩侧索硬化(ALS)疾病,以及自噬和代谢应激障碍,包括肥胖、代谢综合征的研究、神经免疫学和炎症。

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