Description | CNTFisasurvivalpromotingfactorfordifferenttypesofneuronsinvitroandinvivo.TheessentialstructuralfeaturesfortheBIOLOGicalfunctionofhumanCNTFwereinvestigatedbyThier,M.etal.Theyshowedthatdeletionof14N-terminaland18C-terminalaminoacidssignificantlyincreasedbioactivitycomparedtowild-typeCNTF.FUNCTION:CNTFisasurvivalfactorforvariousneuronalcelltypes.Seemstopreventthedegenerationofmotoraxonsafteraxotomy.SUBUNIT:Homodimer.SUBCELLULARLOCATION:Cytoplasm.TISSUESPECIFICITY:Nervoussystem.PHARMACEUTICAL:CNTFisbeingtestedunderthenameAxokinebyRegeneronPharmaceuticalsfortreatmentofhumanmotorneurondiseases,suchasamyotrophiclateralsclerosis(ALS).Asitinducessubstantialweightloss,preferentiallyoffatasopposedtoleanbodymass,itisbeingusedforobesitytreatment.SIMILARITY:BelongstotheCNTFfamily. |
BatchNo. | Seeproductlabel |
Unitsize | 100µg |
Sequence | Histidine-V5epitopefusedtohumanCNTF(aa:15-200)MRGSHHHHHHGMASMTGGQQMGRDLYDDDDKDPTLDLCSRSIWLARKIRSDLTALTESYVKHQGLNKNINLDSADGMPVASTDQWSELTEAERLQENLQAYRTFHVLLARLLEDQQVHFTPTEGDFHQAIHTLLLQVAAFAYQIEELMILLEYKIPRNEADGMPINVGDGGLFEKKLWGLKVLQELSQWTVRSIHDLRFISSHQTGIPARGSHYIANNKKM |
OtherNames | CiliaryNeuroTrophicFactor |
Accession | CNTF_HUMAN |
Producedin | E.coli |
MolecularWeight | 22.8kDa |
Purity | 95%bySDS-PAGE |
Biol.activity | Increasedsurvivalpromotingactivityonneurons |
Form | Lyophilised |
Reconstitution | Reconstitutethefreeze-driedCNTFproteininthebufferofchoice,forexamplePBS. |
Storage | Aliquotandkeepat-20°Cforlong-termstorage.Forshorttermkeepat4°C.Avoidrepetitivefreeze/thawcycles. |
SpecificReferences | WilliamsECetal.(2014)MutantastrocytesdifferentiatedfromRettsyndromepatients-specificiPSCshaveadverseeffectsonwild-typeneurons.HumMolGenet.2014Jun1;23(11):2968-80. |
GeneralReferences | 1.Lin,L.F.etal(1989)Science246,1023-5 2.Stockli,K.A.etal(1991)JCellBiol115,447-59 3.Saggio,I.etal(1995)EmboJ14,3045-54 4.Hermann,D.M.etal(2001)NeurobiolDis8,655-66 5.Thier,M.etal(1995)JNeurosciRes40,826-35 |
Biosensis专注于神经科学领域的抗体和试剂的开发,特别是神经营养因子和神经营养因子受体。 近30年来,Biosensis一直是该领域的全球领航者和OEM供应商。除神经营养因子,我们的神经科学产品组合还被广泛用于神经退行性疾病、神经发育和神经代谢的研究。重点研究领域包括阿尔茨海默氏症(AD)、帕金森氏症(PD)和肌萎缩侧索硬化(ALS)疾病,以及自噬和代谢应激障碍,包括肥胖、代谢综合征的研究、神经免疫学和炎症。