Description | Neurturin(NTN)isamemberoftheGDNFfamilyofneurotrophicfactors.Thisproteinisapotentsurvivalfactorforseveralpopulationsofcentralandperipheralneuronsinmatureanddevelopingrodents.FUNCTION:Supportsthesurvivalofsympatheticneuronsinculture.MayregulatethedevelopmentandmaintenanceoftheCNS.Mightcontrolthesizeofnon-neuronalcellpopulationsuchashaemopoieticcells.SUBUNIT:Homodimer;disulfide-linked.SUBCELLULARLOCATION:Secretedprotein.DISEASE:DefectsinNRTNareacauseofHirschsprungdisease(HSCR).InassociationwithmutationsofRETgene,andpossIBLywithotherloci,defectsinNRTNareinvolvedinHirschsprungdisease.Thisgeneticdisorderofneuralcrestdevelopmentischaracterizedbytheabsenceofintramuralganglioncellsinthehindgut,oftenresultinginintestinalobstruction.SIMILARITY:BelongstotheTGF-betafamily.GDNFsubfamily. |
BatchNo. | Seeproductlabel |
Unitsize | 100ug |
Antigen | RecombinanthumanNRTNproteinproducedusingCHO-basedsUSPensioncellline.Proteinwaspurifiedfromthecellculturesupernatant. |
AntibodyType | Polyclonal |
Producedin | Rabbit |
Applications | Westernblot(WB)atasuggesteddilutionof1:500-1:1,000.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser. |
Specificity | Antibodydoesnotshowcross-reactivitytootherGDNF-familyproteins. |
SpeciesAgainst | Human |
Form | ConcentratedammoniumsulphateinPBSpH7.4. |
Storage | Storeat+4°Cuponreceipt.Asproductis(NH4)2SO4(ammoniumsulfate)precipitate,mixwellbypipettingorvortexingpriortouse. |
ExpiryDate | 12monthsafterpurchase |
Biosensis专注于神经科学领域的抗体和试剂的开发,特别是神经营养因子和神经营养因子受体。 近30年来,Biosensis一直是该领域的全球领航者和OEM供应商。除神经营养因子,我们的神经科学产品组合还被广泛用于神经退行性疾病、神经发育和神经代谢的研究。重点研究领域包括阿尔茨海默氏症(AD)、帕金森氏症(PD)和肌萎缩侧索硬化(ALS)疾病,以及自噬和代谢应激障碍,包括肥胖、代谢综合征的研究、神经免疫学和炎症。