Description | CDNF(conserveddopamineneurotrophicfactor)isatrophicfactorformidbraindopamineneuronsinvivo.Itpreventsthe6-OHDA-(Lindholmetal.20007;Voutilainenetal.,2011)andMPTP-induceddegeneration(Airavaaraetal.,2012)ofdopamineneuronsinrodentmodelsofParkinsonsdisease.WhenadmiNISTeredafter6-OHDAorMPTPlesioningitrestoresthedopaminergicfunctionandpreventsdegenerationofdopamineneuronsinsubstantianigraparscompacta. |
Relatedproducts | M-1676-100;M-1677-100;BEK-2212-2PELISA |
BatchNo. | Seeproductlabel |
Unitsize | 100ug |
Antigen | RecombinanthumanCDNFproteinproducedusingCHO-basedcellline.Purifiedfromcellculturesupernatant. |
Sequence | wholemolecule,UniprotQ49AH0 |
AntibodyType | Polyclonal |
Isotype | IgG |
OtherNames | ARMETL1 |
Accession | Q49AH0 |
Producedin | Rabbit |
MolecularWeight | ~15kDareducinggel,matureforms |
Purity | Affinitypurified |
Applications | Westernblot(WB)atasuggesteddilutionof1:6,0001:10,000.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser. |
Specificity | CDNF(conserveddopamineneurotrophicfactor) |
SpeciesAgainst | Human |
Form | ConcentratedammoniumsulphateinPBSpH7.4containingnopreservatives. |
Reconstitution | Storeantibodystocksolutionat+4°Cuponreceipt.DONOTFREEZE.Thisproductisan(NH4)2SO4precipitate.Touse,mixwellbypipettingorvortexinggentlyprioruse,thenwithdrawthedesiredamountofantibodystocksolutionanddiluteintoyourantibodydilutionbufferandusenormally. Alternatively,materialcanbecentrifugedat10Kxgfor5minutesandtheliquidsulfatesolutioncarefullyremoved.ThenprecipitatedantibodycanberesUSPendedin0.1MP,250mMNaCL,pH7.4solution.Thesolutionshouldthenbedividedintoworkingaliquotsandstoredat-80°Cuntilused.Preventmultiplefreezethawcyclesofaliquotsforbestproductlife. |
Storage | Storeat+4°Cuponreceipt;Donotfreeze.Seereconstitutioninstructionsforhandlinginformation. |
ExpiryDate | 12monthsafterpurchase |
Biosensis专注于神经科学领域的抗体和试剂的开发,特别是神经营养因子和神经营养因子受体。 近30年来,Biosensis一直是该领域的全球领航者和OEM供应商。除神经营养因子,我们的神经科学产品组合还被广泛用于神经退行性疾病、神经发育和神经代谢的研究。重点研究领域包括阿尔茨海默氏症(AD)、帕金森氏症(PD)和肌萎缩侧索硬化(ALS)疾病,以及自噬和代谢应激障碍,包括肥胖、代谢综合征的研究、神经免疫学和炎症。