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主营:抗体类、生化类试剂、ELISA试剂盒、组织染色细胞可视化试剂、针对神经科学和细胞疾病研究产品和纯化蛋白等
℡ 4000-520-616
℡ 4000-520-616
Biosensis/Rabbit polyclonal antibody to Tyrosine Kinase Receptor A [TrkA] (342-361): Affinity purified/R-1362-100/100 µg
产品编号:R-1362-100
市  场 价:¥5940.00
场      地:美国(厂家直采)
产品分类: 抗体类>一抗>功能性抗体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$297.00
品      牌: Biosensis
公      司:Biosensis
公司分类:
Biosensis/Rabbit polyclonal antibody to Tyrosine Kinase Receptor A [TrkA] (342-361): Affinity purified/R-1362-100/100 µg
商品介绍
DescriptionTrkAisamemberoftheneurotrophictyrosinekinasereceptorfamily.Itisamembrane-boundreceptorthatuponneurotrophinbinding,phosphorylatesitselfandmembersoftheMAPKpathway.TrkAisrequiredforhigh-affinitybindingtonervegrowthfactor(NGF),neurotrophin-3andneurotrophin-4/5butnotbrain-derivedneurotrophicfactor(BDNF).TrkAleadstocelldifferentiationsandmayplayaroleinspecifyingsensoryneuronsubtypes.Ithasacrucialroleinthedevelopmentandfunctionofthenociceptivereceptionsystemaswellasestablishmentofthermalregulationviasweating.SUBUNIT:Existsinadynamicequilibriumbetweenmonomeric(lowaffinity)anddimeric(highaffinity)structures.SUBCELLULARLOCATION:Cellmembrane;single-passtypeImembraneprotein.EndocytosedtotheendosomesupontreatmentofcellswithNGF.ALTERNATIVEPRODUCTS:2namedisoformsproducedbyalternativesplicing.BothisoformshavesimilarBIOLOGicalproperties.TISSUESPECIFICITY:IsoformTrkA-IIisprimarilyexpressedinneuronalcells.IsoformTrkA-Iisfoundinnon-neuronaltissues.MutationsinTrkAhavebeenassociatedwithcongenitalinsensitivitytopain,anhidrosis,self-mutalatingbehaviour,mentalretardationandcancer.
BatchNo.Seeproductlabel
Unitsize100µg
AntigenAsyntheticpeptidecorrespondingtoasequenceinthemiddleregionofhumanTrkA(342-361aa)RHGCLRLNQPTHVNNGNYTL).Thissequenceisidenticaltotherelatedratandmousesequencesaswell.
SequenceRHGCLRLNQPTHVNNGNYTL
AntigenLocationWithintheIg-likeC2-type2Domainspanningtwoglycosylationsites;epitopelieswithintheextracellularregionoftheprotein(33-423aa)within100aminoacidsofitsentryintothetransmembranedomain(aa424-439)[UniprotP04629(NTRK1_HUMAN)
AntibodyTypeAntiserum
IsotypeIgG
OtherNamesTropomyosin-relatedkinasereceptor,Highaffinitynervegrowthfactorreceptor,Neurotrophictyrosinekinasereceptortype1,TRK1transformingtyrosinekinaseprotein,p140-TrkA,Trk-A,GENENAME:NTRK1,TRK.
AccessionP04629NTRK1_HUMAN;
ProducedinRabbit
PurityAffinitypurified
ApplicationsWesternBlotting(WB).Aconcentrationof0.1-0.5µg/mlisrecommendedforWB.HumanTrkA(isoformTrkA-II)hasapredictedlengthof796aminoacidsandMWof87kDa.Aconcentrationof0.5-1.0µg/mlisrecommendedtodetecttheproteininformalinfixedandparaffinembeddedtissues.Heatmediatedantigenretrievalisrecommended.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser.
SpecificityThespecificityofthisantibodyhasbeenconfirmedbyWBandIHCagainsttheantigen.
AntibodyAgainstTyrosineKinaseReceptorA,TrkA
Cross-reactivityHuman;rat;predictedtoreactwithmouseduetosequencehomology;
BlastURLClickhere
FormLyophilizedwith5mgBSA,0.9mgNaCl,0.2mgNa2HPO4,0.05mgThimerosal,0.05mgNaN3addedaspreservative
AppearanceLyophilizedwhitepowder
ReconstitutionReconstitutein100µlofsteriledistilledwatertoachieveanantibodyconcentrationof1mg/ml.Centrifugetoremoveanyinsolublematerial.
StorageAtleast12monthsafterpurchaseat2-4°C(lyophilizedformulations).Afterreconstitution,aliquotandstoreat-20°CforahigherstABIlity.Avoidfreeze-thawcycles.
ExpiryDate12monthsafterpurchase
品牌介绍

Biosensis专注于神经科学领域的抗体和试剂的开发,特别是神经营养因子和神经营养因子受体。 近30年来,Biosensis一直是该领域的全球领航者和OEM供应商。除神经营养因子,我们的神经科学产品组合还被广泛用于神经退行性疾病、神经发育和神经代谢的研究。重点研究领域包括阿尔茨海默氏症(AD)、帕金森氏症(PD)和肌萎缩侧索硬化(ALS)疾病,以及自噬和代谢应激障碍,包括肥胖、代谢综合征的研究、神经免疫学和炎症。

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