Description | TrkCisamemberoftheneurotrophictyrosinereceptorkinasefamily.TrkCisamembrane-boundreceptorthatuponneurotrophinbinding,phosphorylatesitselfandmembersoftheMAPKpathway.TrkCisthereceptorforneurotrophin-3(NT-3). SignallingthroughTrkCleadstocelldifferentiationandmayplayaroleinthedevelopmentofproprioceptiveneuronsthatsensebodyposition.SUBUNIT:Existsinadynamicequilibriumbetweenmonomeric(lowaffinity)anddimeric(highaffinity)structures.SUBCELLULARLOCATION:Membrane;single-passtypeImembraneprotein.ALTERNATIVEPRODUCTS:4namedisoformsproducedbyalternativesplicing.Additionalisoformsseemtoexist.MutationsinTrkChavebeenassociatedwithmedulloblastomas,secretorybreastcarcinomasandothercancers. |
BatchNo. | Seeproductlabel |
Unitsize | 100µl |
Antigen | ExtracellulardomainofglycosylatedhumanTrkCproteinproducedinCHOcellswasusedastheimmunogen. |
OtherNames | Tropomyosin-relatedkinasereceptor;NT-3growthfactorreceptor;Neurotrophictyrosinekinasereceptortype3;TrkCtyrosinekinase;GP145-TrkC;Trk-C;NTRK3;TRKC |
Accession | NTRK3_HUMAN |
Producedin | Rabbit |
Purity | Wholeserum |
Applications | IHC.Adilutionof1:1000to1:3000isrecommendedforthisapplication.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser. |
Specificity | Specificitywasdemonstratedbyimmunohistochemistry.Thisantibodywasusedtostaincryostatsectionsoftheratperipheralsensoryganglia. |
Cross-reactivity | Reactswithhuman,ratandmouseTrkC.Otherspecieshavenotyetbeentested. |
Form | Lyophilised |
Reconstitution | Reconstitutein100µlofsterilewater.Centrifugetoremoveanyinsolublematerial. |
Storage | Afterreconstitutionkeepaliquotsat-20ºCforahigherstABIlity,andat4ºCwithanappropriateantibacterialagent.Glycerol(1:1)maybeaddedforanadditionalstability.Avoidrepetitivefreeze/thawcycles. |
References | ZhangFX,etal.(2005)BrainRes.1062(1-2)pp.92-100. |
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