商品介绍
| Description | TrkAisamemberoftheneurotrophictyrosinekinasereceptorfamily.Itisamembrane-boundreceptorthatuponneurotrophinbinding,phosphorylatesitselfandmembersoftheMAPKpathway.TrkAisrequiredforhigh-affinitybindingtonervegrowthfactor(NGF),neurotrophin-3andneurotrophin-4/5butnotbrain-derivedneurotrophicfactor(BDNF).TrkAleadstocelldifferentiationsandmayplayaroleinspecifyingsensoryneuronsubtypes.Ithasacrucialroleinthedevelopmentandfunctionofthenociceptivereceptionsystemaswellasestablishmentofthermalregulationviasweating.SUBUNIT:Existsinadynamicequilibriumbetweenmonomeric(lowaffinity)anddimeric(highaffinity)structures.SUBCELLULARLOCATION:Cellmembrane;single-passtypeImembraneprotein.EndocytosedtotheendosomesupontreatmentofcellswithNGF.ALTERNATIVEPRODUCTS:2namedisoformsproducedbyalternativesplicing.BothisoformshavesimilarBIOLOGicalproperties.TISSUESPECIFICITY:IsoformTrkA-IIisprimarilyexpressedinneuronalcells.IsoformTrkA-Iisfoundinnon-neuronaltissues.MutationsinTrkAhavebeenassociatedwithcongenitalinsensitivitytopain,anhidrosis,self-mutalatingbehaviour,mentalretardationandcancer. |
| BatchNo. | Seeproductlabel |
| Unitsize | 100µl |
| Antigen | ExtracellulardomainofglycosylatedhumanTrkAproteinproducedinmammaliancellswasusedastheimmunogen. |
| OtherNames | Tropomyosin-relatedkinasereceptor;Highaffinitynervegrowthfactorreceptor;Neurotrophictyrosinekinasereceptortype1;TRK1transformingtyrosinekinaseprotein;p140-TrkA;Trk-A;NTRK1;TRK; |
| Accession | NTRK1_HUMAN |
| Producedin | Rabbit |
| Purity | Wholeserum |
| Applications | IHC(1:1000dilution),WesternBlotting(denaturingandnon-reducingSDS-PAGE,1:1000-1:2500dilution),1-siteELISA(1:5000dilution).Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser. |
| Specificity | Specificitywasdemonstratedbyimmunohistochemistry.Whenusedforimmunohistochemistryinratdorsalrootganglia,stainingisrestrictedtotheknowndistributionofTrkA,thatisinsmall,nociceptiveneurons. |
| Cross-reactivity | Reactswithhuman,ratandmouseTrkA.Otherspeciesnotyettested. |
| Form | Lyophilised |
| Reconstitution | Reconstitutein100µlofsterilewater.Centrifugetoremoveanyinsolublematerial. |
| Storage | Afterreconstitutionkeepaliquotsat-20ºCforahigherstABIlity,andat4ºCwithanappropriateantibacterialagent.Glycerol(1:1)maybeaddedforanadditionalstability.Avoidrepetitivefreeze/thawcycles. |
| SpecificReferences | KobayashiKetal.(2015)NerveGrowthFactorSignalsasPossIBLePathogenicBioMarkersforPerineuralInvasioninAdenoidCysticCarcinom.OtolaryngolHeadNeckSurg.2015Aug;153(2):218-24.Species:Human.Application:IHC. UrenRTetal.(2014)Anovelroleofsuppressorofcytokinesignaling-2intheregulationofTrkAneurotrophinreceptorbiology.JNeuRochem.2014May;129(4):614-27.Species:Mouse.Application:IF. |
| References | 1.ZhangFX,etal.(2005)BrainRes16;1062(1-2)pp.92-100. 2.GearhartDA,etal.(2006)JNeurosciMethods.150(2)pp.159-173. |
品牌介绍
Biosensis专注于神经科学领域的抗体和试剂的开发，特别是神经营养因子和神经营养因子受体。 近30年来，Biosensis一直是该领域的全球领航者和OEM供应商。除神经营养因子，我们的神经科学产品组合还被广泛用于神经退行性疾病、神经发育和神经代谢的研究。重点研究领域包括阿尔茨海默氏症（AD）、帕金森氏症（PD）和肌萎缩侧索硬化（ALS）疾病，以及自噬和代谢应激障碍，包括肥胖、代谢综合征的研究、神经免疫学和炎症。
公司介绍
产品分类
TR-200-BG
PE-1243-50
Antibody Kits
PE-1246-5
TR-100-BG
S-1754-500
Neurotrophic Factors
Diabetes & Obesity
Intracellular Trafficking
PE-1239-5
Neuropeptides & Receptors
B-100-PS
Receptors & Channel Molecules
2 Plate ELISA kits
M-1763-100-FT
TR-200-BGT
PE-1239-2
PE-1242-5
M-1249-100
Neurotrophic Factor Receptors
Cell Cycle Regulators
S-1759-100
PE-1606-100
PE-1762-100
B-200-PS
PE-019-100
PE-1241-5
PE-003-100
1 Plate ELISA kits
BL-003-1000
PE-1246-2
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PE-1253-100
TR-100-FJ
BL-005-500
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M-1728-100
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PE-001-100
PE-1608-1
TR-400-AG
PE-1243-25
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PE-1608-5
TR-100-FJT
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PE-1242-2
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PE-019-25
PE-1608-10
BL-002-1250
Receptor Body Chimeras
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BL-001-1250
Cancer
PE-019-500
Stem Cells
Junction Proteins
TR-300-AG
Apoptosis
PE-1252-100
Growth Factors
Development
Alzheimer\'s / Parkinson\'s
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