商品介绍
| Description | FUNCTION:FunctionsasasortingreceptorintheGolgicompartmentandasaclearancereceptoronthecellsurface.RequiredforproteintransportfromtheGolgiapparatustothelysosomesbyapathwaythatisindependentofthemannose-6-phosphatereceptor(M6PR).AlsorequiredforproteintransportfromtheGolgiapparatustotheendosomes.PromotesneuronalapoptosisbymediatingendocytosisoftheproapoptoticprecursorformsofBDNF(proBDNF)andNGFB(proNGFB).Alsoactsasareceptorforneurotensin.MaypromotemineralizationoftheextracellularmatrixduringosteogenicdifferentiationbyscavengingextracellularLPL.ProbablyrequiredinADIpocytesfortheformationofspecializedstoragevesiclescontainingtheglucosetransporterSLC2A4/GLUT4(GLUT4storagevesicles,orGSVs).ThesevesiclesprovideastablepoolofSLC2A4andconferincreasedresponsivenesstoinsulin.MayalsomediatetransportfromtheendoplasmicreticulumtotheGolgi.SUBUNIT:InteractswithLPLandSLC2A4.InteractswiththecytosolicadapterproteinsGGA1andGGA2.Interactswithnumerousligandsincludingthereceptor-associatedproteinLRPAP1/RAP,GM2AandPSAP.FormsacomplexwithNGFRwhichbindsspecificallytotheprecursorformsofNGFB(proNGFB)andBDNF(proBDNF).SUBCELLULARLOCATION:Membrane;single-passtypeImembraneprotein.Localizedtomembranesoftheendoplasmicreticulum,endosomes,Golgistack,lysosomesandnucleus.Asmallfractionoftheproteinisalsolocalizedtotheplasmamembrane.MayalsobefoundinSLC2A4/GLUT4storagevesicles(GSVs)inadipocytes.Localizationtotheplasmamembraneinadipocytesmaybeenhancedbyinsulin.TISSUESPECIFICITY:Expressedathighlevelsinbrain,spinalcord,heart,skeletalmuscle,thyroid,placentaandtestis.Expressedatlowerlevelsinlymphoidorgans,kidney,colonandliver.INDUCTION:Duringosteoblastdifferentiation.DOMAIN:TheN-terminalpropeptidemayfacilitateprecursortransportwithintheGolgistack.IntrachainbindingoftheN-terminalpropeptideandtheextracellulardomainmayalsoinhibitprematureligandbinding.DOMAIN:Theextracellulardomainmaybeshedfollowingproteasecleavageinsomecelltypes.PTM:TheN-terminalpropeptideiscleavedbyfurinandpossIBLyotherhomologousproteases.PTM:Contains8intrachaindisulfidebonds.PTM:N-glycosylated.SIMILARITY:Contains9BNRrepeats. |
| BatchNo. | Seeproductlabel |
| Unitsize | 100µl |
| Antigen | ExtracellulardomainofglycosylatedhumansortilinproducedinCHOcellswasusedastheimmunogen. |
| OtherNames | Neurotensinreceptor3;NTR3;NT3;Glycoprotein95;Gp95;100kDaNTreceptor;SORT1; |
| Accession | SORT_HUMAN |
| Producedin | Rabbit |
| Purity | Wholeserum |
| Applications | IHC,1-siteELISA(1:5000dilution).Adilutionof1:1000isrecommendedforIHC.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser. |
| Specificity | Specificitywasdemonstratedbyimmunohistochemistry. |
| Cross-reactivity | Reactswithhuman,ratandmouseSortilin.Otherspeciesnotyettested. |
| Form | Lyophilised |
| Reconstitution | Reconstitutein100µlofsterilewater.Centrifugetoremoveanyinsolublematerial. |
| Storage | Afterreconstitutionkeepaliquotsat-20ºCforahigherstABIlity,andat4ºCwithanappropriateantibacterialagent.Glycerol(1:1)maybeaddedforanadditionalstability.Avoidrepetitivefreeze/thawcycles. |
| References | 1.ChenZY,etal.J.Neurosci.25(26)pp6156-6166. 2.MazellaJ,etal.(2001).CellSignal13pp1-6. |
品牌介绍
Biosensis专注于神经科学领域的抗体和试剂的开发，特别是神经营养因子和神经营养因子受体。 近30年来，Biosensis一直是该领域的全球领航者和OEM供应商。除神经营养因子，我们的神经科学产品组合还被广泛用于神经退行性疾病、神经发育和神经代谢的研究。重点研究领域包括阿尔茨海默氏症（AD）、帕金森氏症（PD）和肌萎缩侧索硬化（ALS）疾病，以及自噬和代谢应激障碍，包括肥胖、代谢综合征的研究、神经免疫学和炎症。
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