Description | FUNCTION:LowaffinityreceptorwhichcanbindtoNGF,BDNF,NT-3,andNT-4.Canmediatecellsurvivalaswellascelldeathofneuralcells.SUBUNIT:Homodimer;disulfide-linked.Interactswithp75NTR-associatedcelldeathexecutor.InteractswithTRAF2,TRAF4,TRAF6,PTPN13andRANBP9.InteractsthroughTRAF6withSQSTM1whichbridgesNGFRtoNTRK1.InteractswithBEX1andNGFRAP1/BEX3.SUBCELLULARLOCATION:Membrane;single-passtypeImembraneprotein.DOMAIN:DeathdomainisresponsIBLeforinteractionwithRANBP9.PTM:N-andO-glycosylated.PTM:O-linkedglycansconsistofGal(1-3)GalNAccoreelongatedby1or2NeuNAc.PTM:Phosphorylatedonserineresidues.SIMILARITY:Contains1deathdomain.SIMILARITY:Contains4TNFR-Cysrepeats. |
BatchNo. | Seeproductlabel |
Unitsize | 100µl |
Antigen | Extracellulardomainofhumanp75NTR |
OtherNames | Low-affinitynervegrowthfactorreceptor;NGFreceptor;Gp80-LNGFR;p75ICD;Lowaffinityneurotrophinreceptorp75NTR;CD271antigen |
Accession | TNR16_HUMAN |
Producedin | Rabbit |
Purity | Wholeserum |
Applications | IHC,immunofluorescence.Recommendedtobeusedatadilutionof1:500to1:2000.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser. |
Specificity | IHCshowsspecificstainingforp75NTR. |
Cross-reactivity | Thisantibodyisknowntoreacttoratp75NTR. |
Form | Lyophilised |
Reconstitution | Reconstitutein100µlofsterilewater.Centrifugetoremoveanyinsolublematerial. |
Storage | Afterreconstitutionkeepaliquotsat-20ºCforahigherstABIlity,andat4ºCwithanappropriateantibacterialagent.Glycerol(1:1)maybeaddedforanadditionalstability.Avoidrepetitivefreeze/thawcycles. |
ExpiryDate | 12monthsafterpurchase |
Biosensis专注于神经科学领域的抗体和试剂的开发,特别是神经营养因子和神经营养因子受体。 近30年来,Biosensis一直是该领域的全球领航者和OEM供应商。除神经营养因子,我们的神经科学产品组合还被广泛用于神经退行性疾病、神经发育和神经代谢的研究。重点研究领域包括阿尔茨海默氏症(AD)、帕金森氏症(PD)和肌萎缩侧索硬化(ALS)疾病,以及自噬和代谢应激障碍,包括肥胖、代谢综合征的研究、神经免疫学和炎症。