Description | FUNCTION:Receptorfortheglialcellline-derivedneurotrophicfactor,artemin.Mediatestheartemin-inducedautophosphorylationandactivationoftheRETreceptortyrosinekinase(Bysimilarity).SUBCELLULARLOCATION:Cellmembrane;lipid-anchor;GPI-anchor(Bysimilarity).SIMILARITY:BelongstotheGDNFRfamily. |
BatchNo. | Seeproductlabel |
Unitsize | 100µl |
Antigen | Asyntheticpeptide(MGLSWSPRPPL)aspartofmouseGFRalpha-3protein(aa:1-11)conjugatedtoKLH |
OtherNames | GDNFfamilyreceptoralpha-3;GFR-alpha-3 |
Accession | GFRA3_MOUSE |
Producedin | Rabbit |
Purity | Wholeserum |
Applications | IHC,WB.Adilutionof1:500to1:1000isrecommendedforbothapplications.ThisantibodystainsnicelylargeneuronsintheratDRG.Specifically,ifyouwouldliketoperformWBusingratbrainhomogenatedetectingGFRalpha-3,thisistheantibodytobeused.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser. |
Specificity | WesternblotanalysisindicatesahighlevelofspecificitytoGFRalpha-3forthisantiserum. |
Cross-reactivity | ThisantibodyisknowntoreactwithratGFRalpha-2. |
Blastit | Ifyouwouldliketousethisproductinanotherspeciesotherthanthosespecifiedhere,ortoseethesharedIDbetweentheimmunogenusedhereindifferentspeicesand/orothermolecules,simplycopytheimmunogen(fromtheImmunogenfield)andpasteitHEREandblast/formatit.Notethat,antiseraraisedagainstsyntheticpeptidesarequiteoftenveryspecificforthatpeptideie,onlyonesingleaminoaciddifferencemaybeenoughtorestrictthespecificitytoaparticularmolecule.Regardless,youcanalwayscontactusifyouneedassistancewiththis. |
Form | Lyophilised |
Reconstitution | Reconstitutein100µlofsterilewater.Centrifugetoremoveanyinsolublematerial. |
Storage | Afterreconstitutionkeepaliquotsat-20ºCforahigherstABIlity,andat4ºCwithanappropriateantibacterialagent.Glycerol(1:1)maybeaddedforanadditionalstability.Avoidrepetitivefreeze/thawcycles. |
References | Naveilhanetal.(1998)Proc.Natl.Acad.Sci.USA.95(3):1295 |
Biosensis专注于神经科学领域的抗体和试剂的开发,特别是神经营养因子和神经营养因子受体。 近30年来,Biosensis一直是该领域的全球领航者和OEM供应商。除神经营养因子,我们的神经科学产品组合还被广泛用于神经退行性疾病、神经发育和神经代谢的研究。重点研究领域包括阿尔茨海默氏症(AD)、帕金森氏症(PD)和肌萎缩侧索硬化(ALS)疾病,以及自噬和代谢应激障碍,包括肥胖、代谢综合征的研究、神经免疫学和炎症。