![Biosensis/Mouse monoclonal antibody to Tyrosine Kinase Receptor A (TrkA, 235-246), extracellular domain [Clone BS470]: IgG/M-](images/biosensis/201712/M-1723-100_Flow.jpg)
产品编号：M-1723-100
市 场 价：¥5940.00
场 地：美国(厂家直采)
联系QQ：1570468124
电话号码：4000-520-616
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info@ebiomall.com
商品介绍
| Description | TrkAisamemberoftheneurotrophictyrosinekinasereceptorfamily.Itisamembrane-boundreceptorthatuponneurotrophinbinding,phosphorylatesitselfandmembersoftheMAPKpathway.TrkAisrequiredforhigh-affinitybindingtonervegrowthfactor(NGF),neurotrophin-3andneurotrophin-4/5butnotbrain-derivedneurotrophicfactor(BDNF).TrkAleadstocelldifferentiationsandmayplayaroleinspecifyingsensoryneuronsubtypes.Ithasacrucialroleinthedevelopmentandfunctionofthenociceptivereceptionsystemaswellasestablishmentofthermalregulationviasweating.SUBUNIT:Existsinadynamicequilibriumbetweenmonomeric(lowaffinity)anddimeric(highaffinity)structures.SUBCELLULARLOCATION:Cellmembrane;single-passtypeImembraneprotein.EndocytosedtotheendosomesupontreatmentofcellswithNGF.ALTERNATIVEPRODUCTS:2namedisoformsproducedbyalternativesplicing.BothisoformshavesimilarBIOLOGicalproperties.TISSUESPECIFICITY:IsoformTrkA-IIisprimarilyexpressedinneuronalcells.IsoformTrkA-Iisfoundinnon-neuronaltissues.MutationsinTrkAhavebeenassociatedwithcongenitalinsensitivitytopain,anhidrosis,self-mutalatingbehaviour,mentalretardationandcancer(Reference:www.uniprot.com). |
| BatchNo. | Pleaserefertotheproductlabel. |
| Unitsize | 100µg |
| Antigen | AsyntheticpeptidefromtheextracellulardomainofhumanTrkA(C-SATVMKSGGLPS,aa:235-246)hasbeenusedastheimmunogen. |
| Sequence | SATVMKSGGLPS |
| AntigenLocation | Peptidesequenceislocatedwithintheextracellulardomainconsistingofaminoacids33-432. |
| AntigenLength | 12aminoacids |
| AntibodyType | MousemonoclonalIgG |
| Isotype | IgG3,k-lightchain |
| Clone | BS470 |
| OtherNames | Tropomyosin-relatedkinasereceptor;Highaffinitynervegrowthfactorreceptor;Neurotrophictyrosinekinasereceptortype1;TRK1transformingtyrosinekinaseprotein;p140-TrkA;Trk-A;NTRK1;TRK |
| Accession | Uniprot:P04629;NTRK1_HUMAN |
| Producedin | Mouse |
| MolecularWeight | GlycosylatedhumanTrkAhasanapparentmolecularweightof140kDa |
| Purity | ProteinGpurifiedmouseimmunoglobulin |
| Applications | Flowcytometry:20µg/mL. Immunocytochemistry:1-5µg/mL. FlowcytometrydataandimmunofluorescencestainingofTrkA(extracellulardomain)receptorinSHSY-5YcellshasshownthatdetectionofTrkAexpressiondependsonitscellularlocalization(membranevs.internalstores).Thus,permeABIlizationofcellsmayberequired,despitethatcloneBS470wasraisedagainsttheextracellulardomainofTrkA. Otherapplicationsnotyettested.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser. |
| Specificity | TrkA.Doesnotcross-reactwithTrkBorTrkC. |
| SpeciesAgainst | Human |
| AntibodyAgainst | Human |
| Cross-reactivity | ReactswithhumanTrkA.Whilenottestedyet,M-1723-100isnotexpectedtoreactwithTrkAfromotherspeciesduetoaminoacidsequencedissimilarity. |
| Form | LyophilizedfromPBS,pH7.4,containing3%trehalosewithoutpreservatives. |
| Reconstitution | Spinvialbrieflybeforeopening.Reconstitutein100µLofsterilewater.Centrifugetoremoveanyinsolublematerial.Finalbuffercontainsnopreservatives. |
| Storage | Afterreconstitutiondivideintoaliquotsandstoreat-20°Cforahigherstability.Antibodycontainsnopreservatives.Storeat4°Cwithanappropriateantibacterialagent.Usesterilemethods.HighestpurityGlycerol(1:1)maybeaddedforanadditionalstabilitywhenstoredatrefrigeratedorfreezingtemperatures.Avoidrepetitivefreeze/thawcycles. |
| ExpiryDate | 12monthsafterpurchaseifunopened. |
品牌介绍
Biosensis专注于神经科学领域的抗体和试剂的开发，特别是神经营养因子和神经营养因子受体。 近30年来，Biosensis一直是该领域的全球领航者和OEM供应商。除神经营养因子，我们的神经科学产品组合还被广泛用于神经退行性疾病、神经发育和神经代谢的研究。重点研究领域包括阿尔茨海默氏症（AD）、帕金森氏症（PD）和肌萎缩侧索硬化（ALS）疾病，以及自噬和代谢应激障碍，包括肥胖、代谢综合征的研究、神经免疫学和炎症。
公司介绍
产品分类
TR-200-BG
PE-1243-50
Antibody Kits
PE-1246-5
TR-100-BG
S-1754-500
Neurotrophic Factors
Diabetes & Obesity
Intracellular Trafficking
PE-1239-5
Neuropeptides & Receptors
B-100-PS
Receptors & Channel Molecules
2 Plate ELISA kits
M-1763-100-FT
TR-200-BGT
PE-1239-2
PE-1242-5
M-1249-100
Neurotrophic Factor Receptors
Cell Cycle Regulators
S-1759-100
PE-1606-100
PE-1762-100
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PE-1241-5
PE-003-100
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BL-005-500
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M-1728-100
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PE-001-100
PE-1608-1
TR-400-AG
PE-1243-25
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PE-1608-5
TR-100-FJT
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PE-1242-2
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PE-019-25
PE-1608-10
BL-002-1250
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BL-001-1250
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PE-019-500
Stem Cells
Junction Proteins
TR-300-AG
Apoptosis
PE-1252-100
Growth Factors
Development
Alzheimer\'s / Parkinson\'s
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