![Biosensis/Mouse monoclonal antibody to rat p75NTR [MC192] - FITC/M-016-100-FT/100 µg](images/biosensis/201712/M-016-50-FT_Basal_FB_web_LR.jpg)
产品编号：M-016-100-FT
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商品介绍
| Description | MonoclonalantibodyMC192againsttheratlowaffinitynervegrowthfactorreceptor(p75NTR)isderivedfromthefusionofSp2/0-Ag14myelomacellswithmouseimmunesplenocytes.MC192monoclonalantibodywasoriginallygeneratedbyChandlersetal.p75NTRwasoriginallydiscoveredasalowaffinitynervegrowthfactorreceptor.Lateritwasfoundthatitwasthereceptorforallneurotrophins.Itmediatessignalsofneurotrophinsforneuronalsurvival,apoptosis,neuriteoutgrowthandsynapticplasticity.Recently,ithasbeenrevealedthatp75NTRnotonlyactsasthereceptorforneurotrophinsbutalsothereceptorformanyotherpathologicalligandssuchasprions,rABIesvirusandamyloidbeta.p75NTRalsoactsasaco-receptorforNOGOwhichmediatesinhibitorysignalsofmyelinassociatedprotein.p75NTRishighlyexpressedinanumberofnon-neuronalandneuronalcellsincludingmotorneuronsduringdevelopmentandalsoindamagedneurons.MC192hasapotentialuseastheligandforgenedeliveryintop75NTR-expressingratcellsviaareceptor-mediatedmechanism.FUNCTION:LowaffinityreceptorwhichcanbindtoNGF,BDNF,NT-3,andNT-4.Canmediatecellsurvivalaswellascelldeathofneuralcells.SUBUNIT:Homodimer;disulfide-linked.Interactswithp75NTR-associatedcelldeathexecutor.InteractswithNGFRAP1/BEX3.InteractswithTRAF2,TRAF4,TRAF6,PTPN13andRANBP9. |
| Relatedproducts | M-1763-100-FT,Non-specificControlIgG,cloneX63(Monoclonal)-FITC |
| BatchNo. | Seeproductlabel |
| Unitsize | 100µg |
| Antigen | Ratp75NTR |
| Isotype | IgG1 |
| Clone | MC192 |
| OtherNames | Low-affinitynervegrowthfactorreceptor;NGFreceptor;Gp80-LNGFR;p75ICD;Lowaffinityneurotrophinreceptorp75NTR |
| Accession | TNR16_RAT |
| Producedin | Mouse |
| Purity | Immunoglobulin(IgG1)waspurifiedusingProteinGcolumn(AmershamPharmacia),polishedwithSephacryl200HR(AmershamPharmacia)inPBS.TheantibodywasthenconjugatedtoFluoresceinisomer1(FITC,Sigma).Aminimumfluorescein:proteinratioof3:1isguaranteed.TheconjugatewaspurifiedviagelfiltrationusingaG25finegraingelin10mMTris/50mMNaClsolution. |
| Applications | TheFITCversionofMC192isprimarilytargetedforFACSorIFapplicationsonliveorlightlyfixedcells.Immunofluorescence(1-2ug/mL),flowcytometry(20ug/ml)NGFreceptorp75dynamics,retrogradetransportstudies,studyofintracellulartrafficking.(10-20ug/mL).ELISA(1Suggestedworkingdilutions:TheantibodyisnotappropriateforWesternBlots.AntibodywillnotworkintrADItionalformalinfixedtissues.TherecommendedconcentrationforFACSis20µg/mlandatleast1in5000dilutionisrecommendedfor1siteELISA.Optimalworkingdilutionshouldbedeterminedbytheenduser.MC192isnotsuitableasablockingagent,althoughithasbeenincorrectlyusedforthispurposeinmanypublishedworks.TheantibodywasgeneratedspecificallybyscreeningformonoclonalsthathadtheabilitytoENHANCEthebindingofNGF,thenaturalligandforp75.Therefore,thisantibodyisparticularlyunusual.Thefulldetailscanbefoundintheoriginalpaper,whichislistedonourdatasheet(seeChandleretal,1984).Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser. |
| Specificity | MC192recognizestheextracellulardomainoftheneurotrophinreceptorp75NTRinrat. |
| SpeciesAgainst | Rat |
| Cross-reactivity | Reactswithrat.Doesnotreactwithmouseorhumanp75NGFR |
| Form | Liquid |
| Storage | Theantibodyconjugatecanbestoredat4°Cforupto4monthswiththeadditionofappropriateantibacterialagent. |
| ExpiryDate | Fourmonthsafterpurchase. |
| SpecificReferences | 1.DaviesA.etal(2010)Thealpha2deltasubunitsofvoltage-gatedcalciumchannelsformGPI-anchoredproteins,aposttranslationalmodificationessentialforfunctionProcNatlAcadSciUSA.Jan26;107(4):1654-9 |
| References | 1.Chandler,C.E.etal(1984)JBiolChem259,6882-6889 2.LagaresAetal(2007)Jofneurosci27(30),7939-7953 |
品牌介绍
Biosensis专注于神经科学领域的抗体和试剂的开发，特别是神经营养因子和神经营养因子受体。 近30年来，Biosensis一直是该领域的全球领航者和OEM供应商。除神经营养因子，我们的神经科学产品组合还被广泛用于神经退行性疾病、神经发育和神经代谢的研究。重点研究领域包括阿尔茨海默氏症（AD）、帕金森氏症（PD）和肌萎缩侧索硬化（ALS）疾病，以及自噬和代谢应激障碍，包括肥胖、代谢综合征的研究、神经免疫学和炎症。
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