![Biosensis/Mouse monoclonal antibody to human p75NTR [MLR2]: IgG2a/M-009-100/100 µg](images/biosensis/201712/M-009-100_Merged.jpg)
商品介绍
| Description | p75NTRwasoriginallydiscoveredasalowaffinitynervegrowthfactorreceptor.Lateritwasfoundthatitwasthereceptorforallneurotrophins.Itmediatessignalsofneurotrophinsforneuronalsurvival,apoptosis,neuriteoutgrowthandsynapticplasticity.Recently,ithasbeenrevealedthatp75NTRnotonlyactsasthereceptorforneurotrophinsbutalsothereceptorformanyotherpathologicalligandssuchasprions,rABIesvirusandamyloidbeta.p75NTRalsoactsasaco-receptorforNOGOwhichmediatesinhibitorysignalsofmyelinassociatedprotein.p75NTRishighlyexpressedinanumberofnon-neuronalandneuronalcellsincludingmotorneuronsduringdevelopmentandalsoindamagedneurons.FUNCTION:LowaffinityreceptorwhichcanbindtoNGF,BDNF,NT-3,andNT-4.Canmediatecellsurvivalaswellascelldeathofneuralcells.SUBUNIT:Homodimer;disulfide-linked.Interactswithp75NTR-associatedcelldeathexecutor.InteractswithNGFRAP1/BEX3. |
| BatchNo. | Seeproductlabel |
| Unitsize | 100µg |
| Antigen | Thisantibodywasraisedagainstchimericrecombinanthumanp75proteincoupledtoanFcregionofhumanimmunoglobulin. |
| AntigenLocation | Extracellulardomainofhumanp75NTR |
| AntibodyType | mousemonoclonal |
| Isotype | IgG2a |
| Clone | MLR2 |
| OtherNames | Low-affinitynervegrowthfactorreceptor;NGFreceptor;Gp80-LNGFR;p75ICD;Lowaffinityneurotrophinreceptorp75NTR |
| Accession | P08138TNR16_HUMAN; |
| Producedin | Mouse |
| Purity | ProteinGpurifiedimmunoglobulin |
| Applications | IH(fresh,acetonefixedsectionsonly,epitopeisfixationsensitive),Notsuitableinparaffinembeddedtissues.WesternBlot(non-denaturingconditionsonly)andImmunopanning.Aconcentrationof1-5µg/mlisrecommendedforimmunohistochemistry,immunopanningandWB.ThisantibodyisnotrecommendedfordenaturingWBapplications.Aconcentrationof20µg/mlisrecommendedforimmunofluorescenceandFACS.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser. |
| Specificity | SpecificityhasbeenconfirmedusinganumberoftechniquesasdescribedinthereferencebyRogersetal(2006).Theantibodyrecognizesextracellularp75innativeconfigurations. |
| SpeciesAgainst | antibodyrecognizesp75ECfrommouse,ratandhuman,otherspeciesnotyettested. |
| AntibodyAgainst | originalimmunogenwashumanp75extracellulardomain. |
| Cross-reactivity | Thisantibodyisknowntoreactwithhuman,mouse,ratandguinea-pigp75NTRprotein. |
| Form | LyophilisedfromPBSpH7.4 |
| Reconstitution | Reconstitutein100µlofsterilewater.Centrifugetoremoveanyinsolublematerial. |
| Storage | Afterreconstitutionkeepaliquotsat-20°Cforahigherstability,andat4°Cwithanappropriateantibacterialagent.Glycerol(1:1)maybeaddedforanadditionalstability.Avoidrepetitivefreeze/thawcycles. |
| ExpiryDate | 12monthsafterpurchase |
| SpecificReferences | SvadasanR(2016)"TheroleofRNAbindingproteinsinmotoneurondiseases"PhDThesis.Application:Immunopanning.Species:Mouse. YadavPetal.(2016)"NeurofilamentdepletionimprovesmicrotubuledynamicsviamodulationofStat3/stathminsignaling"ActaNeuropathol.Jul;132(1):93-110.Application:Immunopanning.Species:Mouse. KlausmeyerAetal.(2015)"Isolationandcultureofspinalcordmotorneurons"CurrProtocCellBiol.Mar;66:1.9.1-1.9.10.Application:Immunopanning.Species:Mouse. SmithKAetal.(2015)"Characterizationandchangesinneurotrophinreceptorp75-ExpressingmotorneuronsinSOD1(G93A)G1Hmice."JCompNeurol.523(11):1664-82.Application:Invivotrafficking.Species:Mouse. ShepheardSRetal.(2014)"Theextracellulardomainofneurotrophinreceptorp75asacandidatebioMarkerforamyotrophiclateralsclerosis."PLoSOne.9(1):e87398.Application:IP.Species:Human,mouse. WiszniakSetal.(2013)"TheubiquitinligaseNedd4regulatescranofacialdevelopmentbypromotingcranialneuralcrestcellsurvivalandstem-celllikeproperties."DevBiol.383(2):186-200.Application:IHC.Species:Mouse. PanniPetal.(2013)"PhagocytosisofbacteriabyolfactoryensheathingcellsandSchwanncells"NeurosciLett.Feb13.pii:S0304-3940(13)00109-2.Application:Immunopanning.Species:Mouse. ZhangCetal.(2012)"Suppressionofp75neurotrophinreceptorsurfaceexpressionwithintrabodiesinfluencesBcl-xLmRNAexpressionandneuriteoutgrowthinPC12cells."PLoSOne.7(1):e30684.Application:IF,ELISA,FlowCytometry.Species:Rat. SelvarajBTetal.(2012)"LocalaxonalfunctionofSTAT3rescuesaxondegenerationinthepmnmodelofmotoneurondisease."JCellBiol.199(3):437-51.Application:Immunopanning.Species:Mouse. ChacónPJetal.(2010)"NGF-activatedproteintyrosinephosphatase1BmediatesthephosphorylationanddegradationofI-kappa-BalphacoupledtoNF-kappa-Bactivation,therebycontrollingdendritemorphology."MolCellNeurosci.43(4):384-93.Application:IF.Species:Mouse. RogersMLetal.(2010)"ProNGFmediatesdeathofNaturalKillercellsthroughactivationofthep75NTR-sortilincomplex."JNeuroimmunol.226(1-2):93-103.Application:IF,FlowCytometry.Species:Human. WieseSetal.(2010)"Isolationandenrichmentofembryonicmousemotoneuronsfromthelumbarspinalcordofindividualmouseembryos."NatProtoc.5(1):31-8.Application:Immunopanning.Species:Mouse. GorrieCaetal.(2010)"EffectsofhumanOEC-derivedcelltransplantsinrodentspinalcordcontusioninjury."BrainRes.1337:8-20.Application:IF.Species:Human. DengCetal.(2006)"Survivalandmigrationofhumanandratolfactoryensheathingcellsinintactandinjuredspinalcord."JNeurosciRes.83(7):1201-12.Application:IHC.Species:Rat,human. |
| References | MatusicaDetal.(2008)CharacterisationanduseoftheNSC-34celllinerforstudyofnerurotrophinreceptortrafficking.J.Neurosci.Res.86(3)pp.553-65. HuhCYetal.(2008)ChronicexposuretonervegrowthfactorincreasesacetylcholineandglutamatereleasefromcholinergicneuronsoftheratmedialseptumanddiagonalbandofBocaviamechanismsmediatedbup75NTR.J.Neurosci.28(6)pp.1404-9. LagaresAetal.(2007)Primarysensoryneuronadditionintheadultrattrigeminalganglion:evidenceforneuralcrestglio-neuronalprecursormaturation.J.Neurosci.27(30)pp.7939-53. RogersMLetal.(2006).Functionalmonoclonalantibodiestop75neurotrophinreceptorraisedinknockoutmice.NeurosciMethods.158(1)pp.109-120 |
品牌介绍
Biosensis专注于神经科学领域的抗体和试剂的开发，特别是神经营养因子和神经营养因子受体。 近30年来，Biosensis一直是该领域的全球领航者和OEM供应商。除神经营养因子，我们的神经科学产品组合还被广泛用于神经退行性疾病、神经发育和神经代谢的研究。重点研究领域包括阿尔茨海默氏症（AD）、帕金森氏症（PD）和肌萎缩侧索硬化（ALS）疾病，以及自噬和代谢应激障碍，包括肥胖、代谢综合征的研究、神经免疫学和炎症。
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