![Biosensis/Mouse monoclonal antibody to human p75NTR [MLR2] - FITC/M-018-100-FT/100 µg](images/biosensis/201712/MLR2-Fluorescence-WR.jpg)
产品编号：M-018-100-FT
市 场 价：¥5940.00
场 地：美国(厂家直采)
联系QQ：1570468124
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商品介绍
| Description | p75NTRwasoriginallydiscoveredasalowaffinitynervegrowthfactorreceptor.Lateritwasfoundthatitwasthereceptorforallneurotrophins.Itmediatessignalsofneurotrophinsforneuronalsurvival,apoptosis,neuriteoutgrowthandsynapticplasticity.Recently,ithasbeenrevealedthatp75NTRnotonlyactsasthereceptorforneurotrophinsbutalsothereceptorformanyotherpathologicalligandssuchasprions,rABIesvirusandamyloidbeta.p75NTRalsoactsasaco-receptorforNOGOwhichmediatesinhibitorysignalsofmyelinassociatedprotein.p75NTRishighlyexpressedinanumberofnon-neuronalandneuronalcellsincludingmotorneuronsduringdevelopmentandalsoindamagedneurons.FUNCTION:LowaffinityreceptorwhichcanbindtoNGF,BDNF,NT-3,andNT-4.Canmediatecellsurvivalaswellascelldeathofneuralcells.SUBUNIT:Homodimer;disulfide-linked.Interactswithp75NTR-associatedcelldeathexecutor.InteractswithNGFRAP1/BEX3.InteractswithTRAF2,TRAF4,TRAF6,PTPN13andRANBP9.InteractsthroughTRAF6withSQSTM1whichbridgesNGFRtoNTRK1. |
| Relatedproducts | M-1763-100-FT,Non-specificControlIgG,cloneX63(Monoclonal)-FITC |
| BatchNo. | Seeproductlabel |
| Unitsize | 100µg |
| Antigen | Humanrecombinantp75 |
| Isotype | IgG2a |
| Clone | MLR2 |
| OtherNames | Low-affinitynervegrowthfactorreceptor;NGFreceptor;Gp80-LNGFR;p75ICD;Lowaffinityneurotrophinreceptorp75NTR;Tumornecrosisfactorreceptorsuperfamilymember16;CD271;NGFR;TNFRSF16; |
| Accession | P08138TNR16_HUMAN; |
| Producedin | Mouse |
| Purity | Immunoglobulin(IgG2A)waspurifiedusingProteinGcolumn(AmershamPharmacia),polishedwithSephacryl200HR(AmershamPharmacia)inPBS.TheantibodywasthenconjugatedtoFluoresceinisomer1(FITC,Sigma).Aminimumfluorescein:proteinratioof3:1isguaranteed.TheconjugatewaspurifiedviagelfiltrationusingaG25finegraingelin10mMTris/50mMNaClsolution. |
| Applications | Immunofluorescence,flowcytometry.Suggestedworkingdilutions:Forimmunofluorescenceaconcentrationof1-5µg/mlisrecommended.LIGHTfixationisamust,orunfixedworksbest.Epitopeissensitivetofixation.ThisantibodyisnotrecommendedfordenaturingWBapplications.ForFACSaconcentrationof20µg/mlisrecommended.ThisantibodydoesnotblockNeurotrophinbinding.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser. |
| Specificity | SpecificitywasdemonstratedbyimmunohistochemistryandFACSanalysis.Immunohistochemicalstainingofmotorneuronsinspinalcordfollowinglesionofsciaticnerveandincholinergicneuronsofthebasalforebraincorrespondingtopublishedliterature. |
| Cross-reactivity | Reactswithhuman,mouseandrat.Otherspecieshavenotyetbeentestedbutitisexpectedthatthisantibodywillbeusefulforthestudyofp75inprimatesandotherspecies. |
| Form | Liquid.Bufferis10mMdisodiumphosphate,1.75mMmonopotassiumphosphate,2.7mMpotassiumchloride,135mMsodiumchloride(PBS),pH7.4.Containsnopreservatives. |
| Storage | Theantibodyconjugatecanbestoredat4ºCforupto4monthswiththeadditionofappropriateantibacterialagent. |
| ExpiryDate | Fourmonthsafterpurchase |
| SpecificReferences | HanYCetal.(2016)DirectReprogrammingofMouseFibroblaststoNeuralStemCellsbySmallMolecules.StemCellsInt.2016;2016:4304916. HanYC&ZhouXF.(2015)Methodofproducingmultipotentstemcells.US20150322405A1(patent). ChacónPJ,ArévaloMA,TébarAR.(2010)NGF-activatedproteintyrosinephosphatase1BmediatesthephosphorylationanddegradationofI-kappa-BalphacoupledtoNF-kappa-Bactivation,therebycontrollingdendritemorphology.MolCellNeurosci.2010Apr;43(4):384-93. WieseS,HerrmannT,DrepperC,JablonkaS,FunkN,KlausmeyerA,RogersML,RushRA&SendtnerM(2009)Isolationandenrichmentofembryonicmousemotoneuronsfromthelumbarspinalcordofindividualmouseembryos.NatProtoc.2010;5(1):31-8. |
| References | 1.RogersML,AtmosukartoI,BerhanuDA,MatusicaD,MacardleP,RushRA(2006).Functionalmonoclonalantibodiestop75neurotrophinreceptorraisedinknockoutmice.NeurosciMethods.158(1)pp.109-120 2.MatusicaD,FenechMP,RogersML,RushRA.(2008)CharacterisationanduseoftheNSC-34celllinerforstudyofnerurotrophinreceptortrafficking.J.Neurosci.Res.86(3)pp.553-65. 3.HuhCY,DanikM,ManseauF,TrudeauLE,WilliamsS.(2008)ChronicexposuretonervegrowthfactorincreasesacetylcholineandglutamatereleasefromcholinergicneuronsoftheratmedialseptumanddiagonalbandofBocaviamechanismsmediatedbup75NTR.J.Neurosci.28(6)pp.1404-9. 4.LagaresA,LiHY,ZhouXF,AvendanoC.(2007)Primarysensoryneuronadditionintheadultrattrigeminalganglion:evidenceforneuralcrestglio-neuronalprecursormaturation.J.Neurosci.27(30)pp.7939-53. |
品牌介绍
Biosensis专注于神经科学领域的抗体和试剂的开发，特别是神经营养因子和神经营养因子受体。 近30年来，Biosensis一直是该领域的全球领航者和OEM供应商。除神经营养因子，我们的神经科学产品组合还被广泛用于神经退行性疾病、神经发育和神经代谢的研究。重点研究领域包括阿尔茨海默氏症（AD）、帕金森氏症（PD）和肌萎缩侧索硬化（ALS）疾病，以及自噬和代谢应激障碍，包括肥胖、代谢综合征的研究、神经免疫学和炎症。
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2 Plate ELISA kits
M-1763-100-FT
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