![Biosensis/Mouse monoclonal antibody to human p75NTR [ME20.4]: IgG/M-011-100/100 µg](images/no_picture.gif)
商品介绍
| Description | Nervegrowthfactorreceptor(NGFR)isalsoreferredtoasp75(NTR)duetoitsmolecularmassanditsABIlitytobindatlowaffinitynotonlyNGF(see162030),butalsootherneurotrophins,includingbrain-derivedneurotrophicfactor(BDNF;113505),neurotrophin-3(NTF3;162660),andneurotrophin-4/5(NTF5;162662).Atthetimeofitsdiscovery,NGFRwasconsideredauniquetypeofprotein.Subsequently,however,alargesuperfamilyoftumornecrosisfactorreceptorswerefoundtosharetheoverallstructureofNGFR(4extracellularligand-binding,cysteine-richrepeats,orCRs,andsignalingthroughassociationwith,ordisassociationfrom,cytoplasmicinteractors).TheidentificationofthissuperfamilyhelpedelucidatesomeoftheBIOLOGicfunctionsofNGFR,includingitsultimateinvolvementinthenuclearfactorkappa-B(NFKB;see164011)andapoptosispathways.Asamonomer,NGFRbindsNGFwithlowaffinity.Higheraffinitybindingisachievedbyassociationwithhighermolecularmass,low-affinityneurotrophinreceptors,namelythetropomyosinreceptorkinases,TRKA(NTRK1;191315),TRKB(NTRK2;600456),andTRKC(NTRK3;191316).TRKA,TRKB,andTRKCarespecificforor"preferredby"NGF,NTF5andBDNF,andNTF3,respectively(Ipetal.,1993).NTF3alsobindstoTRKAandTRKB,butwithsignificantlyloweraffinity |
| BatchNo. | Seeproductlabel |
| Unitsize | 100µg |
| Antigen | Thep75NTRantibodywasderivedfromimmunizationofmicewithhumanWM245melanomacells. |
| Clone | ME20.4 |
| OtherNames | Low-affinitynervegrowthfactorreceptor;NGFreceptor;Gp80-LNGFR;p75ICD;Lowaffinityneurotrophinreceptorp75NTR;Tumornecrosisfactorreceptorsuperfamilymember16;CD271;NGFR;TNFRSF16; |
| Accession | P08138TNR16_HUMAN; |
| Producedin | Mouse |
| Purity | Immunoglobulin(IgG2A)waspurifiedusingProteinGcolumn(AmershamPharmacia),polishedwithSephacryl200HR(AmershamPharmacia)inPBSandthenlyophilized.Puritywasanalysedusingelectrophoresis,4-12%BisTrisGel(Invitrogen). |
| Applications | Immunohistochemistry,immunofluorescence,flowcytometry.Suggestedworkingdilutions:ForImmunohistochemistryaconcentrationof2µg/mlisrecommended.AntibodynotappropriateforWesternBlot.ForFACSaconcentrationof20µg/mlisrecommended.Atleast1in5000dilutionisrecommendedfor1siteELISAs.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser. |
| Specificity | Thisantibodyrecognisesp75NTR(lowaffinityneurotrophinreceptor) |
| Cross-reactivity | Reactswithhuman,cat,dog,pig,rabbitandsheep.Doesnotreactwithratormouse. |
| Form | Lyophilised |
| Reconstitution | Reconstitutewiththeadditionof100µlofsterilewater.Centrifugetoremoveanyinsolublematerial. |
| Storage | Afterreconstitutionkeepaliquotsat-20°Cforahigherstability,andat4°Cwithanappropriateantibacterialagent.Glycerol(1:1)maybeaddedforanadditionalstability.Avoidrepetitivefreeze/thawcycles. |
| SpecificReferences | 1.LiuW.etal(2012)DistributionofP75neurotrophinreceptorinadulthumancochlea-animmunohistochemicalstudy.CellTissueRes.2012Mar31. 2.InoueK.etal.(2009)Differentialexpressionofstem-cell-associatedMarkersinhumanhairfollicleepithelialcells.LabInvest.2009Aug;89(8):844-56. 3.ArigaM.etal.(2008)Functionalroleofsortilininmyogenesisanddevelopmentofinsulin-responsiveglucosetransportsysteminC2C12myocytesJBiolChem.2008Apr11;283(15):10208-20 4.RogersMLetal(2010)ProNGFmediatesdeathofNaturalKillercellsthroughactivationofthep75NTR-sortilincomplex.JNeuroimmunol.2010Sep14;226(1-2):93-103. 5.Jiaoetal.Differentiationdefectinneuralcrest-derivedsmoothmusclecellsinpatientswithaortopathyassociatedwithbicUSPidaorticvalves.EBioMedicine(2016)10:282-90. |
| References | 1.WalkerBRetal.(2007)BehavBrainRes176:109-20 2.RossA.H.etal.(1984)Characterizationofnervegrowthfactorreceptorinneuralcresttumorsusingmonoclonalantibodies.ProcNatlAcadSciUSA.1984Nov;81(21):6681-5.ORIGINALPAPER |
品牌介绍
Biosensis专注于神经科学领域的抗体和试剂的开发，特别是神经营养因子和神经营养因子受体。 近30年来，Biosensis一直是该领域的全球领航者和OEM供应商。除神经营养因子，我们的神经科学产品组合还被广泛用于神经退行性疾病、神经发育和神经代谢的研究。重点研究领域包括阿尔茨海默氏症（AD）、帕金森氏症（PD）和肌萎缩侧索硬化（ALS）疾病，以及自噬和代谢应激障碍，包括肥胖、代谢综合征的研究、神经免疫学和炎症。
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