产品编号：R-1651-100
市 场 价：¥5940.00
场 地：美国(厂家直采)
联系QQ：1570468124
电话号码：4000-520-616
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info@ebiomall.com
商品介绍
| Description | GAP43isveryabundantproteinwhichisfoundconcentratedinneurons.Onegroupdiscovereditasoneofthreeproteinswhichbecomesunregulatedduringtheregenerationofthetoadopticnerve(1).ThreeGAPs(Growthassociatedproteins)werediscovered,andthenumber43comesfromtheapparentSDS-PAGEmolecularweightoftheonenamedGAP43.TheHGNCnameforthisproteinis,notsurprisingly,GAP43.LaterworkshowedthatGAP43doesnotrunonSDS-PAGEinafashionwhichaccuratelyreflectsitsmolecularweight,andthatGAP43proteinsfromdifferentspeciesmayrunatdifferentapparentmolecularweights.PartlyduetothesefeaturesGAP43wereindependentlydiscoveredbyseveraldifferentgroupsandthereforehasseveralalternatenames,suchasproteinF1,pp46,neuromodulin,neuralphosphoproteinB-50andcalmodulin-bindingproteinP-57.IneachcasethenumberreflectstheapparentSDS-PAGEmolecularweight,andunderlinestheunusualpropertiesofthismolecule.MammalianGAP43proteinscontainsonly226-243aminoacids,andsotherealmolecularweightis23.61-25.14kDa.GAP43hasbeenextensivelystudiedandisknowntobeamajorproteinkinaseCsubstrateandtobindcalmodulinavidly.GAP43isanchoredtotheplasmamembranebypalmitoylationmodifications. |
| Antigen | C-terminalpeptide217-227ofratandmouseGAP43,whichisKEDPEADQEHA,towhichanNterminalCysteineresiduewasaddedtoallowchemicalcouplingtoKeyholeLimpetHemocyanincarrierprotein. |
| AntibodyType | Polyclonal |
| Isotype | IgG |
| Accession | P07936NEUM_RAT P06837NEUM_MOUSE |
| Producedin | Rabbit |
| Purity | Affinitypurified. |
| Applications | WesternBlotting(WB).Adilutionof1:5,000-1:20,000isrecommended.Adilutionof1:500-2,000isrecommendedforICC/IHC.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser. |
| Specificity | Theantibodyreactswitha43kDabandbyWesternblotonbovinecerebellumhomogenate.Themolecularweightoftheproteinrecognizedcanvary(~43-57kDa)dependingonthespeciesandthepercentageacrylamideusedintheSDS-PAGEgel.Ithasalsobeenusedsuccessfullyforimmunocytochemistry. |
| SpeciesAgainst | Human,ratandbovine.Itisexpectedthatitwillworkonothermammaltissuesduetoaminoacidsequencesimilarity. |
| AntibodyAgainst | GrowthAssociatedProtein43(GAP43) |
| Form | LyophilisedfromPBS,pH7.4containing3%trehalose,withoutpreservatives. |
| Reconstitution | Reconstitutewith100µLsterile-filtered,ultrapurewater,toachieveanantibodyconcentrationof1mg/mL.Centrifugebrieflytoremoveanyinsolublematerial. |
| Storage | Storelyophilised,unopenedvialat2-8°Corlower.Afterreconstitution,preparealiquotsandstoreat-20°Cto-80°CforahigherstABIlity.Avoidfreeze-thawcycles. |
| ExpiryDate | 12monthsafterpurchase(unopenedvial). |
| GeneralReferences | SkeneJH,WillardM.Changesinaxonallytransportedproteinsduringaxonregenerationintoadretinalganglioncells.J.CellBiol.89:86-95(1981). |
品牌介绍
Biosensis专注于神经科学领域的抗体和试剂的开发，特别是神经营养因子和神经营养因子受体。 近30年来，Biosensis一直是该领域的全球领航者和OEM供应商。除神经营养因子，我们的神经科学产品组合还被广泛用于神经退行性疾病、神经发育和神经代谢的研究。重点研究领域包括阿尔茨海默氏症（AD）、帕金森氏症（PD）和肌萎缩侧索硬化（ALS）疾病，以及自噬和代谢应激障碍，包括肥胖、代谢综合征的研究、神经免疫学和炎症。
公司介绍
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PE-1606-100
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