产品编号：R-1687-100
市 场 价：¥5940.00
场 地：美国(厂家直采)
联系QQ：1570468124
电话号码：4000-520-616
邮 箱：
info@ebiomall.com
商品介绍
| Description | AdenylatecyclasesareenzymeswhichinteractwithandareactivatedbytheGTPboundalphasubunitsoftrimericG-proteins.ActivatedadenylatecyclasesareresponsIBLefortheproductionoftheimportant"secondmessenger"signallingmoleculecyclic-AMP,whichisgeneratedfromATP.ThetypeIIIadenylatecyclaseenzymeislocalizedinthemembranessurroundingtheciliainneurons,andourantibodyisanexcellentMarkerofneuronalciliainthebrainandincellsintissueculture.AdenylatecyclasetypeIIIisalargecomplexmoleculeof,inthehuman,1145aminoacidswithadeducedmolecularweightof129kDa.Theproteinmaybevariablyglycosylated,sothatonSDS-PAGEandwesternblotsitrunsasadiffusebandofabout160kDaincortexandabout200kDainolfactoryepithelium.Themoleculehasacomplexstructure,with12transmembranedomainsandtwocyclasedomains.EachcyclasedomainisimmediatelyC-terminalto6transmembranesegments,butonlythesecond,C-terminalcyclaseisbelievedtobecatalyticallyactive. |
| BatchNo. | Seeproductlabel. |
| Unitsize | 100µg |
| Antigen | 20aminoacidpeptideidenticaltotheC-terminusofratACIII(aminoacidsPAAFPNGSSVTLPHQVVDNP) |
| AntibodyType | Polyclonal |
| Isotype | IgG |
| Accession | P21932ADCY3_RAT |
| Producedin | Rabbit |
| Purity | Affinitypurified |
| Applications | WesternBlotting(WB)andImmunocytochemistry(IC).Adilutionof1:5,000-1:10,000isrecommendedforWB.Adilutionof1:500-1:1,000isrecommendedforIC.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser. |
| Specificity | Theantibodystainsabandatabout200kDainolfactoryepitheliumwhichisrichincilia.Fewerciliaarefoundinfrontalcortex,andtheproteinislessheavilyglycosylated,andalessprominentbandisseenatabout160kDa.Ithasalsobeenusedsuccessfullyforimmunocytochemistryonmixedneuron/gliacultures. |
| AntibodyAgainst | AdenylatecyclasetypeIII |
| Cross-reactivity | Theantibodyhasbeendirectlytestedforreactivityinrat.Itisexpectedthatitwillworkonhumanduetohomologywiththeimmunogenandpossiblyothermammaltissues(Human,horse,cow,pig,chicken,mouse). |
| Form | LyophilisedfromPBSpH7.4,containing3%trehalose,withoutpreservatives. |
| Reconstitution | Reconstitutewith100µLsterile-filtered,ultrapurewater,toachieveanantibodyconcentrationof1mg/mL.Centrifugebrieflytoremoveanyinsolublematerial. |
| Storage | Storelyophilised,unopenedvialat2-8°Corlower.Afterreconstitution,preparealiquotsandstoreat-20°Cto-80°CforahigherstABIlity.Avoidfreeze-thawcycles. |
| ExpiryDate | 12monthsafterpurchase(unopenedvial). |
| GeneralReferences | 1.FuchsJL,SchwarkHD.Neuronalprimarycilia:areview.CellBiolInt.28:111-8(2004). 2.LouviAandGroveEA.CiliaintheCNS:thequietorganelleclaimscenterstage.Neuron69:1046-1060(2011). |
品牌介绍
Biosensis专注于神经科学领域的抗体和试剂的开发，特别是神经营养因子和神经营养因子受体。 近30年来，Biosensis一直是该领域的全球领航者和OEM供应商。除神经营养因子，我们的神经科学产品组合还被广泛用于神经退行性疾病、神经发育和神经代谢的研究。重点研究领域包括阿尔茨海默氏症（AD）、帕金森氏症（PD）和肌萎缩侧索硬化（ALS）疾病，以及自噬和代谢应激障碍，包括肥胖、代谢综合征的研究、神经免疫学和炎症。
公司介绍
产品分类
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PE-1243-50
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PE-1246-5
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2 Plate ELISA kits
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PE-1606-100
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