![Biosensis/Mouse monoclonal to Fox1 [Ataxin-2 binding protein1, A2BP1]/M-1688-100/100 uL](images/biosensis/M-1688-100 WB.jpg)
产品编号：M-1688-100
市 场 价：¥5940.00
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商品介绍
| Description | Fox1isoneofafamilyof3mammalianFox1homologues.Fox1wasdiscoveredinC.elegansasageneinvolvedinsexdetermination,andthenameFoxisanacronymof"FeminizinglocusonX"(1).TheC.elegansFox1proteinandits3mammalianhomologuesareallabout46kDaproteinsandeachincludesacentralhighlyconservedRRMtypeRNArecognitionmotif,whichcorrespondstoasmall~70aminoacidstructureconsistingof4betastrandsandtwoalpha-helices.ThisregionisidenticalinallthreemammalianFox1familyproteins.AnalternatenameforFox1isataxin-2bindingprotein1(A2BP1),sinceitwasdiscoveredinayeasttwohybridscreenusingataxin-2asbait(2).AswiththeotherFoxproteins,itisassumedthatFox1/A2BP1hasaroleintheRNAsplicinginthenervoussystem(3).Fox3,aproteinalsoknownasNeuN,isawidelyusedMarkerofneuronalnucleiandproximalcytoplasm(4,5).LikeFox3,Fox1isexpressedinneuronalnuclei,butwithadifferentpatternofexpressionthanFox3.Forexample,inthecerebellumFox3doesnotstainPurkinjeneuronsandGolgineurons,butthesetwoneurontypesarestainedbyFox1antibody(6). |
| BatchNo. | Seeviallabel |
| Unitsize | 100uL |
| Antigen | N-terminal100aminoacidsofhumanFox1asexpressedinandpurifiedfromE.coli. |
| AntibodyType | Monoclonal |
| Isotype | IgG1 |
| OtherNames | ataxin-2bindingprotein1(A2BP1) |
| Producedin | Mouse |
| Applications | Immunocytochemistry(IHC)andWesternBlotting(WB).Adilutionof1:1,000-1:2,000isrecommendedforWB.Adilutionof1:500-1:1000isrecommendedforICC.Theoptimaldilutionshouldbedeterminedbytheenduser. |
| Specificity | Theantibodyreactswitha48kDaand46kDabandbyWesternblotonextractfrommousebrain.Ithasalsobeenusedsuccessfullyforimmunocytochemistryonratneuronalcultures. |
| SpeciesAgainst | Human,bovine,mouseandrat.Itisexpectedthatitwillworkonothermammaltissues. |
| AntibodyAgainst | Fox1/A2BP1 |
| Form | LyophilizedfromPBS.Contains5%trehalose. |
| Appearance | Whitepowder |
| Reconstitution | Reconstituteinsteriledistilledwater.Centrifugetoremoveanyinsolublematerial. |
| Storage | Afterreconstitutionoflyophilizedantibody,aliquotandstoreat-20°CforahigherstABIlity.Avoidfreeze-thawcycles. |
| ExpiryDate | 12monthsafterpurchase |
| GeneralReferences | 1.HodgkinJ,ZellanJD,AlbertsonDG.Identificationofacandidateprimarysexdeterminationlocus,fox-1,ontheXchromosomeofCaenorhaBDitiselegans.Development120:3681-3689(1994).2.ShibataH,HuynhDP,PulstSM.AnovelproteinwithRNA-bindingmotifsinteractswithataxin-2.HumMolGenet.39:1303-13(2000).3.UnderwoodJG,BoutzPL,DoughertyJD,StoilovPandBlackDL.HomologuesoftheCaenorhabditiselegansFox-1proteinareneuronalsplicingregulatorsinmammals.Mol.Cell.Biol.25:10005-10016(2005).4.MullenRJ,BuckCR,SmithAM.NeuN,aneuronalspecificnuclearproteininvertebrates.Development116:201-211(1994).5.KimKK,AdelsteinRS,KawamotoS.Identificationofneuronalnuclei(NeuN)asFox-3,anewmemberoftheFox-1genefamilyofsplicingfactors.J.Biol.Chem.284:31052-31061(2009).6.KimKK,KimYC,AdelsteinRS,KawamotoS.Fox-3andPSFinteracttoactivateneuralcell-specificalternativesplicing.NucleicAcidsRes.39:3064-78(2011). |
品牌介绍
Biosensis专注于神经科学领域的抗体和试剂的开发，特别是神经营养因子和神经营养因子受体。 近30年来，Biosensis一直是该领域的全球领航者和OEM供应商。除神经营养因子，我们的神经科学产品组合还被广泛用于神经退行性疾病、神经发育和神经代谢的研究。重点研究领域包括阿尔茨海默氏症（AD）、帕金森氏症（PD）和肌萎缩侧索硬化（ALS）疾病，以及自噬和代谢应激障碍，包括肥胖、代谢综合征的研究、神经免疫学和炎症。
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