![Biosensis/Mouse monoclonal to Doublecortin [DCX]/M-1648-100/1 Ea](images/biosensis/M-1648-100 WB.jpg)
产品编号：M-1648-100
市 场 价：¥5940.00
场 地：美国(厂家直采)
联系QQ：1570468124
电话号码：4000-520-616
邮 箱：
info@ebiomall.com
商品介绍
| Description | Doublecortin(DCX,alsoknownasDoublin,Lissencephalin-X,DBCNandLis-X)wasoriginallydiscoveredsincedefectsinthegeneencodingitarecausativeofX-linkedlissencephaly,araregroupofbrainmalformationsresultinginasmoothcerebralcortexcausedbyaberrantneuronalmigrationduringdevelopment(1,2).ThenameDoublecortincomesfromtheunusuallayeringofthecortexinthisformoflissencephaly,whichappearstohaveaseconddeepcorticallayerofneurons.Thislayerconsistsofneuronswhichdidnotmigratefromthesubventricularzonetothenormalcorticallayer.Patientswiththisdefectsufferfromseizuresandmentalretardation.FourproteinsencodedbytheDCXproducebandsofabout35kDaand45kDaonWesternblots.The45kDaformisknownasLis-XAwhilethesmallerformsaregeneratedbyalternatetranscription,areallmissingthefirst81aminoacidsofLis-XA,andarereferredtoasLis-XB,Lis-XC,Lis-XD.Thereareminoraminoacidsequencedifferencesbetweenthesethreesmallerisoforms.Alloftheseproteinscontaintwoso-calledDoublecortindomains,eachabout90aminoacidslong,whicharebelievedtofunctioninbindingtomicrotubules,aC-terminalserineandprolinerichregionwhichmaybecomephosphorylatedinvivo.DCXisexpressedveryearlyinneuronaldevelopment,asneuroblastsbecomepost-mitotic,butislostasneuronsmature.DevelopingneuronsstarttoloseDCXexpressionaboutthetimethattheybegintoexpressNeuN.AntibodiestoDCXcanbeusedtoseeifneurogenesisistakingplace. |
| Antigen | FulllengthrecombinanthumanLis-AisoformofDoublecortinpurifiedfromE.coli. |
| AntibodyType | Monoclonal |
| Isotype | IgG2a |
| OtherNames | Doublin,Lissencephalin-X,DBCNandLis-X |
| Producedin | Mouse |
| Applications | Immunohistochemistry(IHC)andWesternBlotting(WB).Adilutionof1:5,000-1:10,000isrecommendedforWB.Adilutionof1:500-1:1000isrecommendedforIHC.Theoptimaldilutionshouldbedeterminedbytheenduser. |
| Specificity | Theantibodyreactswithtwobandsat~45kDaand~35kDawhichshowsthatthemouseanti-DCXantibodybindstoanepitopeintheregionofDCXsharedbyLis-A,andLis-B,Lis-CandLis-D,theCterminal360aminoacidsofLis-A.IthasalsobeenusedsuccessfullyforimmunocytochemistryandisanexcellentMarkerfordevelopingneurons. |
| SpeciesAgainst | Rat.Itisexpectedthatitwillworkonothermammaltissues. |
| AntibodyAgainst | Doublecortin |
| Form | LyophilizedfromPBS.Contains5%trehalose. |
| Appearance | Whitepowder |
| Reconstitution | Reconstituteinsteriledistilledwater.Centrifugetoremoveanyinsolublematerial. |
| Storage | Afterreconstitutionoflyophilizedantibody,aliquotandstoreat-20°CforahigherstABIlity.Avoidfreeze-thawcycles. |
| ExpiryDate | 12monthsafterpurchase |
| GeneralReferences | 1.desPortesV,PinardJM,BilluartP,VinetMC,KoulakoffA,CarriéA,GelotA,DupuisE,MotteJ,Berwald-NetterY,CatalaM,KahnA,BeldjordCandChellyJ.AnovelCNSgenerequiredforneuronalmigrationandinvolvedinX-linkedsubcorticallaminarheterotopiaandlissencephalysyndrome.Cell92:51-61(1998).2.GleesonJG,AllenKM,FoxJW,LampertiED,BerkovicS,SchefferI,CooperEC,DobynsWB,MinnerathSR,RossMEandWalshCA.Doublecortin,abrain-specificgenemutatedinhumanX-linkedlissencephalyanddoublecortexsyndrome,encodesaputativesignalingprotein.Cell92:63-721998.3.JinJ,SuzukiH,HiraiS,MikoshibaKandOhshimaT.JNKphosphorylatesSer332ofdoublecortinandregulatesitsfunctioninneuriteextensionandneuronalmigration.DevNeurobiol.70:929-422010. |
品牌介绍
Biosensis专注于神经科学领域的抗体和试剂的开发，特别是神经营养因子和神经营养因子受体。 近30年来，Biosensis一直是该领域的全球领航者和OEM供应商。除神经营养因子，我们的神经科学产品组合还被广泛用于神经退行性疾病、神经发育和神经代谢的研究。重点研究领域包括阿尔茨海默氏症（AD）、帕金森氏症（PD）和肌萎缩侧索硬化（ALS）疾病，以及自噬和代谢应激障碍，包括肥胖、代谢综合征的研究、神经免疫学和炎症。
公司介绍
产品分类
TR-200-BG
PE-1243-50
Antibody Kits
PE-1246-5
TR-100-BG
S-1754-500
Neurotrophic Factors
Diabetes & Obesity
Intracellular Trafficking
PE-1239-5
Neuropeptides & Receptors
B-100-PS
Receptors & Channel Molecules
2 Plate ELISA kits
M-1763-100-FT
TR-200-BGT
PE-1239-2
PE-1242-5
M-1249-100
Neurotrophic Factor Receptors
Cell Cycle Regulators
S-1759-100
PE-1606-100
PE-1762-100
B-200-PS
PE-019-100
PE-1241-5
PE-003-100
1 Plate ELISA kits
BL-003-1000
PE-1246-2
Sensory Nervous System
PE-1253-100
TR-100-FJ
BL-005-500
Neuroendocrine
M-1728-100
DNA Damage & Repair
PE-001-100
PE-1608-1
TR-400-AG
PE-1243-25
Cell Markers
PE-1608-5
TR-100-FJT
Autophagy
PE-1242-2
Other Neuronal
Neurotransmitters & Enzymes
Antioxidant Enzymes
Neuronal Markers
Tag Antibodies
BL-004-500
PE-019-25
PE-1608-10
BL-002-1250
Receptor Body Chimeras
Signalling & Transcription
Matrix & Adhesion Molecules
BL-001-1250
Cancer
PE-019-500
Stem Cells
Junction Proteins
TR-300-AG
Apoptosis
PE-1252-100
Growth Factors
Development
Alzheimer\'s / Parkinson\'s
销售排行
厂家直采
全球直采 正品优价
正品保障
厂家直发 有线跟踪
正规清关
CIF100%正规报关，提供发票
及时交付
限时必达 不达必赔
总部地址：
江苏省苏州市工业园区星湖街218号 苏州生物医药产业园一期（生物纳米园）A4-216(邮编：215125)
工作时间：周一至周五9:00~18:00
技术支持：
短信：18915418616
服务热线：
4000-520-616（全国）
☏ 0512-67156496（苏州）
版权信息：
© 2015- 苏州蚂蚁淘生物科技有限公司 版权所有 中国
友情链接：
联系QQ:764052152
免责声明：
本站有部分内容来自互联网，如无意中侵犯了某个媒体 、公司 、企业或个人等的知识产权，请来电或致函告之，
本网站将在规定时间内给予删除等相关处理。
本网站将在规定时间内给予删除等相关处理。
扫描二维码关注官方微信
获取最新促销及产品信息