商品介绍
| Description | Proopiomelanocortin(POMC)istheprecursorofthemelanocortinpeptidesalpha,betaandgamma.POMCneuronsinthearcuatenucleusofthehypothalamusfunctionaskeycentralregulatorsoffoodintakeandhomeostaticcontrolofenergybalanceinbothrodentsandnon-humanprimates.MSHincreasesthepigmentationofskinbyincreasingthemelaninproductioninmelanocytes.MSHisproducedinthepituitaryglandandbelongstothePOMCfamily. |
| BatchNo. | Seeproductlabel |
| Unitsize | 50µl |
| Antigen | Asyntheticpeptide(Ac-SYSMEHFRWGKPV)correspondingtotheaminoacids138-150fromhumanProopiomelanocortin(POMC).POMCistheprecursorofthemelanocortinpeptidesalpha,betaandgamma.Thesyntheticpeptidewasconjugatedtoacarrierproteintoenhancetheimmunologicalresponse. |
| OtherNames | Proopiomelanocortin;POMC;alpha-melanocytestimulatinghormone;melanotropinalpha |
| Accession | COLI_HUMAN |
| Producedin | Guineapig |
| Purity | Neatserum |
| Applications | IHC.Aconcentrationof1in2,000isrecommendedforIHC.IHCperformedinsheepbrain(hypothalamus)demonstratesintensestainingofcells.Nostainingisevidentwhentheprimaryantibodyispre-absorbedwith0.5mg/mlofalphaMSH.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser. |
| Specificity | Specificitywasdemonstratedbyimmunohistochemistry. |
| Cross-reactivity | Thisantibodyisknowntoreactwithhuman,ratandsheep.Otherspecieshavenotyetbeentested. |
| Blastit | Ifyouwouldliketoseethesharedidentitybetweendifferentspeciesorotherproteins,followthelinkintheAccessionfield,selectthesequence(makesurethatyouareselectingthesequencethatyouareinterestedin,asthesequencemaybetheprecursorratherthanthematureproteinforexample)andcopyandpasteitHEREandblast/formatit. |
| Form | Lyophilised |
| Reconstitution | Reconstitutein50µlsterilewater.Centrifugetoremoveanyinsolublematerial. |
| Storage | Itisrecommendedthatathawedsampleisstoredat4ºCfornolongerthan2weeks.Allocationofappropriateanti-bacterialagentcanincreaseshelflifebyseveralweeks.Dilutedserumshouldbepreparedasrequired.LongtermstABIlityrequiresstorage,preferablyinsmallaliquotsat-20ºCorlower.Glycerol(1:1)canbeaddedtoneatserumforadditionalstabilityifintendedusedoesnotpreventthis. |
| ExpiryDate | 12monthsuponreconstitution. |
| GeneralReferences | CardosoRC,AlvesBR,SharptonSM,WilliamsGL,AmstaldenM(2015).NutritionalProgrammingofAcceleratedPubertyinHeifers:InvolvementofPro-OpiomelanocortinNeuronesintheArcuateNucleus.JNeuroendocrinol.2015Aug;27(8):647-57. GraysonBE,AllenSE,BillesSK,WilliamsSM,SmithMS,GroveKL(2006).Prenataldevelopmentofhypothalamicneuropeptidesystemsinthenonhumanprimate.Neuroscience.2006Dec28;143(4):975-86. |
品牌介绍
Biosensis专注于神经科学领域的抗体和试剂的开发，特别是神经营养因子和神经营养因子受体。 近30年来，Biosensis一直是该领域的全球领航者和OEM供应商。除神经营养因子，我们的神经科学产品组合还被广泛用于神经退行性疾病、神经发育和神经代谢的研究。重点研究领域包括阿尔茨海默氏症（AD）、帕金森氏症（PD）和肌萎缩侧索硬化（ALS）疾病，以及自噬和代谢应激障碍，包括肥胖、代谢综合征的研究、神经免疫学和炎症。
公司介绍
产品分类
TR-200-BG
PE-1243-50
Antibody Kits
PE-1246-5
TR-100-BG
S-1754-500
Neurotrophic Factors
Diabetes & Obesity
Intracellular Trafficking
PE-1239-5
Neuropeptides & Receptors
B-100-PS
Receptors & Channel Molecules
2 Plate ELISA kits
M-1763-100-FT
TR-200-BGT
PE-1239-2
PE-1242-5
M-1249-100
Neurotrophic Factor Receptors
Cell Cycle Regulators
S-1759-100
PE-1606-100
PE-1762-100
B-200-PS
PE-019-100
PE-1241-5
PE-003-100
1 Plate ELISA kits
BL-003-1000
PE-1246-2
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PE-1253-100
TR-100-FJ
BL-005-500
Neuroendocrine
M-1728-100
DNA Damage & Repair
PE-001-100
PE-1608-1
TR-400-AG
PE-1243-25
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PE-1608-5
TR-100-FJT
Autophagy
PE-1242-2
Other Neuronal
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Tag Antibodies
BL-004-500
PE-019-25
PE-1608-10
BL-002-1250
Receptor Body Chimeras
Signalling & Transcription
Matrix & Adhesion Molecules
BL-001-1250
Cancer
PE-019-500
Stem Cells
Junction Proteins
TR-300-AG
Apoptosis
PE-1252-100
Growth Factors
Development
Alzheimer\'s / Parkinson\'s
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