商品介绍
| Description | TheneuraladhesionmoleculeContactin-6,alsoknownasNB-3,isacontactin/F3subgroupmemberofimmunoglobulinsuperfamily.Itisexpressedexclusivelyinthenervoussystemandmainlyupregulatedattheearlypostnatalstageduringmousebraindevelopment.EmployingNorthernblotanalysisKameietalfoundthatamongstdifferentregionsoftheadulthumannervoussystemcerebellumexpressedhighestlevelofNB-3mRNA.TheexpressionofNB-3inthecerebellumincreasesuntiladulthood.Incontrast,theexpressioninthecerebrumdeclinestoalowlevelafterpostnatalday7.NB-3likeotherneuralrecognitionmoleculesplaysavitallyimportantroleinaxonalguidanceduringdevelopment,plasticity,andmaintenanceofsynapticconnectionsintheadultbrain.CuietalrecentlyshowedthatNB-3actsasanovelNotchligandtoparticipateinoligodendrocytegeneration.FurThermore,NB-3triggersnucleartranslocationoftheNotchintracellulardomainandpromotesoligodendrogliogenesisfromProgenitorcellsanddifferentiationofoligodendrocyteprecursorcellsviaDeltex1.Inprimaryoligodendrocytes,NB-3increasesmyelin-associatedglycoproteintranscripts.Hence,theNB-3/Notchsignalingpathwaymaybeworthwhileacloserexaminationforitspotentialforthetreatmentofdemyelinatingdiseases.HumanNB-3shareswithratNB-386%identityinnucleotidesequencesand90%identityinaminoacidsequences.FUNCTION:Contactinsmediatecellsurfaceinteractionsduringnervoussystemdevelopment.ParticipatesinoligodendrocytesgenerationbyactingasaligandofNOTCH1.ItsassociationwithNOTCH1promotesNOTCH1activationthroughthereleasednotchintracellulardomain(NICD)andsubsequenttranslocationtothenucleus.Involvedinmotorcoordination.SUBCELLULARLOCATION:Cellmembrane;lipid-anchor;GPI-anchor.ALTERNATIVEPRODUCTS:2namedisoformsproducedbyalternativesplicing.TISSUESPECIFICITY:Expressedinbrain.Inbrain,itispreferentiallyexpressedintheaccessoryolfactorybulb,layersII/IIIandVofthecerebralcortex,piriformcortex,anteriorthalamicnuclei,locuscoeruleusoftheponsandmesencephalictrigeminalnucleusandinPurkinjecellsofthecerebellum.DEVELOPMENTALSTAGE:Highlyexpressedafterbirth,reachingamaximumatthepostnatalday7,anddeclinesthereafterinthecerebrum,whereasitincreasesinthecerebellumtoadulthood. |
| BatchNo. | Seeproductlabel |
| Unitsize | 100µl |
| Antigen | Asyntheticpeptide(KLHKMSSLSSVGVQILKPSTQF)aspartofratcontactin-6conjugatedtoKLHhasbeenusedastheimmunogen. |
| OtherNames | NeuralrecognitionmoleculeNB-3;mNB-3 |
| Accession | CNTN6_RAT |
| Producedin | Rabbit |
| Purity | Wholeserum |
| Applications | IHC.Adilutionof1:1000to1:5000isrecommended.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser. |
| Specificity | ThisantiserumstainsbeautifullytheNB3inDRG,whereitnicelystainsasubpopulationofneuronsandinthetrigeminalnerveroot,wherestainingisrestrictedtotheoligodendrocytes. |
| Cross-reactivity | ConfirmedtoreactwithratContactin-6 |
| Blastit | Ifyouwouldliketousethisproductinanotherspeicesotherthanthosespecifiedhere,ortoseethesharedidentitybetweentheimmunogenusedhereindifferentspeciesand/orothermolecules,simplycopytheimmunogen(fromtheImmunogenfield)andpasteitHEREandblast/formatit.Notethat,antiseraraisedagainstsyntheticpeptidesarequiteoftenveryspecificforthatpeptideie,onlyonesingleaminoaciddifferencemaybeenoughtorestrictthespecificitytoaparticularmolecule.Regardless,youcanalwayscontactusifyouneedassistancewiththis. |
| Form | Lyophilised |
| Reconstitution | Reconstitutein100µlofsterilewater.Centrifugetoremoveanyinsolublematerial. |
| Storage | Afterreconstitutionkeepaliquotsatminus20ºCforincreasedstABIlity,andat4ºCwithanappropriateantibacterialagent.Glycerol(1:1)maybeaddedforanadditionalstability.Avoidrepetitivefreeze/thawcycles. |
| ExpiryDate | 12monthsafterpurchase |
| References | 1.Kameietal(1998)JNeurosciRes.51(3):275-83 2.Takedaetal(2003)JNeurobiol.56(3):252-65 3.Leeetal(2000)Gene.245(2):253-66 4.Cuietal(2004)JBiolChem.279(24):25858-65 |
品牌介绍
Biosensis专注于神经科学领域的抗体和试剂的开发，特别是神经营养因子和神经营养因子受体。 近30年来，Biosensis一直是该领域的全球领航者和OEM供应商。除神经营养因子，我们的神经科学产品组合还被广泛用于神经退行性疾病、神经发育和神经代谢的研究。重点研究领域包括阿尔茨海默氏症（AD）、帕金森氏症（PD）和肌萎缩侧索硬化（ALS）疾病，以及自噬和代谢应激障碍，包括肥胖、代谢综合征的研究、神经免疫学和炎症。
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