Description | CateninbetaisanadherensjunctionproteinandhasaroleintheregulationofcelladhesionandinsignaltransductionthroughtheWntpathway.Atleast2isoformsareproducedbyalternativesplicing. |
BatchNo. | Seeproductlabel |
Unitsize | 100µg |
Antigen | Asyntheticpeptide(C-SNQLAWFDTDL)correspondingtotheaminoacidregion771-781ofhumanCateninbetacoupledtocarrierproteinKLH. |
OtherNames | Cateninbeta-1;Beta-catenin;CTNNB1;CTNNB;_-Catenin; |
Accession | P35222CTNB1_HUMAN; |
Producedin | Sheep |
Purity | Affinitypurified |
Applications | WesternBlotting(WB)andImmunoprecipitation.Aconcentrationof1.0µg/mlisrecommendedforWB.HumanCateninbeta(isoform1)hasapredictedlengthof781residuesandMWof86kDa.Aconcentrationof5µg/500µgoflysateisrecommendedforimmunoprecipitation.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser. |
Specificity | ThespecificityofthisantibodyhasbeenconfirmedbyWBagainsttheantigen.Thisantibodywasalsovalidatedforimmunoprecipitationinratliverlysate(datanotshown). |
Cross-reactivity | Human;mouse;rat; |
Blastit | Ifyouwishtousethisproductinaspeciesotherthanthosespecifiedhereandwanttodeterminetheaminoacidsequencehomologybetweentheimmunogenandthecorrespondingproteininthatspecies,simplycopytheaminoacidsequenceforthisimmunogenandtestitontheBLASTdatabasethatyoucanaccessthroughthelinkbelow.Pleasenotethatantibodiesraisedagainstsyntheticpeptidesarequiteoftenveryspecificforthatpeptide.Whatthismeansinpractiseisthatasingleaminoaciddifferencemaybeenoughtorestrictthespecificitytoaparticularmolecule.TheBLASTdatabasecanalsobeusedtocompareanyaminoacidsequencebetweenspeciesandbetweenprotein.ThefullaminoacidsequenceofthetargetproteincanbefoundbyfollowingthelinkintheAccessionfield.YoucanthensearchanyaminoacidsequenceinthetargetproteinusingtheBLASTdatabase.Whenselectingasequencetosearch,pleasechoosecarefully,asthesequenceyouchoosemaybeaprecursorratherthanthematureproteinforexample. |
Form | Lyophilisedfrom10mMsodiumHEPES(pH7.5),150mMNaCl,and0.05%sodiumazide. |
Reconstitution | Reconstitutein100µlofsterilewater.Centrifugetoremoveanyinsolublematerial. |
Storage | Atleast12monthsafterpurchaseat2-4°C(lyophilizedformulations).Afterreconstitution,aliquotandstoreat-20°CforahigherstABIlity.Avoidfreeze-thawcycles. |
ExpiryDate | 12monthsafterpurchase |
Biosensis专注于神经科学领域的抗体和试剂的开发,特别是神经营养因子和神经营养因子受体。 近30年来,Biosensis一直是该领域的全球领航者和OEM供应商。除神经营养因子,我们的神经科学产品组合还被广泛用于神经退行性疾病、神经发育和神经代谢的研究。重点研究领域包括阿尔茨海默氏症(AD)、帕金森氏症(PD)和肌萎缩侧索硬化(ALS)疾病,以及自噬和代谢应激障碍,包括肥胖、代谢综合征的研究、神经免疫学和炎症。