商品介绍
| Description | FUNCTION:Subunitofclathrin-associatedadaptorproteincomplex1thatplaysaroleinproteinsortinginthelate-Golgi/trans-Golginetwork(TGN)and/orendosomes.TheAPcomplexesmediateboththerecruitmentofclathrintomembranesandtherecognitionofsortingsignalswithinthecytosolictailsoftransmembranecargomolecules.SUBUNIT:Adaptorproteincomplex1(AP-1)isanheterotetramercomposedoftwolargeadaptins(gamma1/AP1G1orgamma2/AP1G2andbeta1A/AP1B1orbeta1B/AP1B1),amediumadaptin(mu1A/AP1M1ormu1B/AP1M2)andasmalladaptin(sigma1A/AP1S1orsigma1B/AP1S2orsigma1C/AP1S3).SUBCELLULARLOCATION:Golgiapparatus.Cytoplasmicvesicle;cytoplasmicvesiclemembrane;peripheralmembraneprotein;cytoplasmicside.Note=ComponentofthecoatsurroundingthecytoplasmicfaceofcoatedvesicleslocatedattheGolgicomplex.ALTERNATIVEPRODUCTS:2namedisoformsproducedbyalternativesplicing.TISSUESPECIFICITY:Widelyexpressed.DISEASE:DeletionoftheAP1B1genemayplayaroleinthetumOrigenesisofmeningiomas.SIMILARITY:Belongstotheadaptorcomplexeslargesubunitfamily. |
| BatchNo. | Seeproductlabel |
| Unitsize | 100µl |
| Antigen | Asyntheticpeptide(C-KKGEIFELKAELNSDKKEK)correspondingtotheaminoacids11-29ofhumanAP-1complexsubunitbeta-1conjugatedtodiphtheriatoxinhasbeenusedastheimmunogen.ThepeptideishomologouswiththecorrespondingsequencederivedfromAP-1complexsubunitbeta-1proteininmouse,ratandbovine. |
| OtherNames | Adapter-relatedproteincomplex1beta-1subunit;Beta-adaptin1;AdaptorproteincomplexAP-1beta-1subunit;GolgiadaptorHA1/AP1adaptinbetasubunit;Clathrinassemblyproteincomplex1betalargechain;AP1B1;ADTB1;BAM22 |
| Accession | AP1B1_HUMAN AP1B1_MOUSE AP1B1_RAT AP1B1_BOVIN |
| Producedin | Rabbit |
| Purity | Wholeserum |
| Applications | IHC,WB.Thisantibodyworkssuperblyinimmunohistochemistryonfrozenorparaffinembeddedtissues.Antigenretrievalhasbeenusedintestingbutmaynotbenecessary.Typicalworkingdilutionsforroutineimmunohistochemistryare1:1000to1:5000dependingontissueanddetectionmethod.Forwesternblottingadilutionrangeof1:100to1:10000isrecommended.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser. |
| Specificity | ThisantibodyhasbeenshowntobespecificforAP-1complexsubunitbeta-1. |
| Cross-reactivity | Ratandhuman,otherspecieshavenotyettested. |
| Blastit | Ifyouwouldliketousethisproductinanotherspeicesotherthanthosespecifiedhere,ortoseethesharedidentitybetweentheimmunogenusedhereindifferentspeciesand/orothermolecules,simplycopytheimmunogen(fromtheImmunogenfield)andpasteitHEREandblast/formatit.Notethat,antiseraraisedagainstsyntheticpeptidesarequiteoftenveryspecificforthatpeptideie,onlyonesingleaminoaciddifferencemaybeenoughtorestrictthespecificitytoaparticularmolecule.Regardless,youcanalwayscontactusifyouneedassistancewiththis. |
| Form | Lyophilised |
| Reconstitution | Reconstitutein100µlofsterilewater.Centrifugetoremoveanyinsolublematerial. |
| Storage | Afterreconstitutionkeepaliquotsat-20ºCforahigherstABIlity,andat4ºCwithanappropriateantibacterialagent.Avoidrepetitivefreeze/thawcycles.Glycerol(1:1)maybeaddedforanadditionalstability. |
| ExpiryDate | 12monthsafterpurchase |
| References | 1.PeyrardM,etal.Genomics36:112-117(1996). 2.PeyrardM,etal.Hum.Mol.Genet.3:1393-1399(1994). 3.SackstederC.A,etal.Biochemistry45:8009-8022(2006). 4.GuilbaudC,etal.Mamm.Genome8:651-656(1997). 5.KirchhausenT,etal.Proc.Natl.Acad.Sci.U.S.A.86:2612-2616(1989). |
品牌介绍
Biosensis专注于神经科学领域的抗体和试剂的开发，特别是神经营养因子和神经营养因子受体。 近30年来，Biosensis一直是该领域的全球领航者和OEM供应商。除神经营养因子，我们的神经科学产品组合还被广泛用于神经退行性疾病、神经发育和神经代谢的研究。重点研究领域包括阿尔茨海默氏症（AD）、帕金森氏症（PD）和肌萎缩侧索硬化（ALS）疾病，以及自噬和代谢应激障碍，包括肥胖、代谢综合征的研究、神经免疫学和炎症。
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