Description | Dynactinsubunit1(DCTN1)ispartofalargemacromolecularcomplexofatleast10components.Itisrequiredforcytoplasmicdynein-drivenretrogrademovementofvesiclesandorganellesalongmicrotubules.Dynein-dynactininteractionisakeycomponentofthemechanismofaxonaltransportofvesiclesandorganelles.Dynactinsubunit1bindsdirectlytomicrotubulesandtocytoplasmicdynein.Itisexpressed inthebrainandlocalisestothecytoplasmandtheCytoskeleton.Itbelongstothedynactin150kDasubunitfamilyandcontainsoneCAP-Glydomain.AbnormalitiesinDCTN1causeprogressivelowermotorneurondisease(PLMND). |
BatchNo. | Seeproductlabel |
Unitsize | 100µg |
Antigen | Partialsequencerecombinantproteinofhumandynactinsubunit1(aminoacids1082-1270)withGSTtag |
Clone | [1E12] |
OtherNames | 150kDadynein-associatedpolypeptide;DP-150;DAP-150;p150-glued;p135;DCTN1 |
Accession | DCTN1_HUMAN |
Producedin | Mouse |
Purity | ProteinGpurifiedimmunoglobulin |
Applications | ThisantibodyisrecommendedforWBanddirectELISA.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser. |
Specificity | ThespecificityofthisantibodyhasbeenconfirmedbyWBandELISAagainsttherecombinantprotein. |
Cross-reactivity | Nootherspecieshavebeentested. |
Blastit | Ifyouwouldliketoseethesharedidentitybetweendifferentspeciesorotherproteins,followthelinkintheAccessionfield,selectthesequence(makesurethatyouareselectingthesequencethatyouareinterestedin,asthesequencemaybetheprecursorratherthanthematureproteinforexample)andcopyandpasteitHEREandblast/formatit. |
Form | LyophilisedfromPBSpH7.2 |
Reconstitution | Reconstitutein100µlofsterilewater.Centrifugetoremoveanyinsolublematerial. |
Storage | Afterreconstitutionkeepaliquotsat-20ºCforhigherstABIlity.Glycerol(1:1)maybeaddedforadditionalstability.Avoidrepetitivefreeze/thawcycles. |
ExpiryDate | 12monthsafterpurchase |
Biosensis专注于神经科学领域的抗体和试剂的开发,特别是神经营养因子和神经营养因子受体。 近30年来,Biosensis一直是该领域的全球领航者和OEM供应商。除神经营养因子,我们的神经科学产品组合还被广泛用于神经退行性疾病、神经发育和神经代谢的研究。重点研究领域包括阿尔茨海默氏症(AD)、帕金森氏症(PD)和肌萎缩侧索硬化(ALS)疾病,以及自噬和代谢应激障碍,包括肥胖、代谢综合征的研究、神经免疫学和炎症。