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主营:抗体类、生化类试剂、ELISA试剂盒、组织染色细胞可视化试剂、针对神经科学和细胞疾病研究产品和纯化蛋白等
℡ 4000-520-616
℡ 4000-520-616
Biosensis/Rabbit polyclonal to mouse Interleukin 1beta (IL-1beta) Affinity purified/R-1658-100/100 ug
产品编号:R-1658-100
市  场 价:¥6540.00
场      地:美国(厂家直采)
产品分类: 抗体类>一抗>多克隆抗体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$327.00
品      牌: Biosensis
公      司:Biosensis
公司分类:
Biosensis/Rabbit polyclonal to mouse Interleukin 1beta (IL-1beta) Affinity purified/R-1658-100/100 ug
商品介绍
DescriptionInterleukin-1beta(IL-1β)alsoknowascatabolin,isacytokineproteinthatinhumansisencodedbytheIL1Bgene,whichlocalizestothelongarmofchromosome2.Interleukin1wasdiscoveredbyGeryin1972.Henameditlymphocyte-activatingfactor(LAF)becauseitwasalymphocytemitogen.Itwasnotuntil1985thatinterleukin1wasdiscoveredtoconsistoftwodistinctproteins,nowcalledinterleukin-1alphaandinterleukin-1beta.IL-1βisamemberoftheinterleukin1cytokinefamily.Thiscytokineisproducedbyactivatedmacrophagesasaproprotein,whichisproteolyticallyprocessedtoitsactiveformbycaspase1(CASP1/ICE).Thiscytokineisanimportantmediatoroftheinflammatoryresponse,andisinvolvedinavarietyofcellularactivities,includingcellproliferation,differentiation,andapoptosis.Theinductionofcyclooxygenase-2(PTGS2/COX2)bythiscytokineinthecentralnervoussystem(CNS)isfoundtocontributetoinflammatorypainhypersensitivity.Reference:http://en.wikipedia.org/wiki/IL1B
BiosensisrabbitpolyclonaltomouseIL-1βhasbeentestedagainstmousetissuelysatesandreactswellinwesternblots.Otherapplicationsandotherspecieshavenotyetbeentested.
BatchNo.seeviallabel
Unitsize100ug
AntigenAminoacids250-265aa,(FLGNNSGQDIIDFTME)frommouseIL-betaprotein
SequenceFLGNNSGQDIIDFTME
AntigenLocationC-terminus
AntigenLength15aminoacids
AntibodyTypeRabbitIgG
IsotypeIgG
AccessionP10749Here
ProducedinRabbit
CompoundNameInterleukin1beta,IL-1beta
Purity100ugofaffinitypurifiedrabbitIgGin5mgBSA,0.9mgNaCl,0.2mgNa2HPO4,0.05mgThimerosal,0.05mgNaN3buffer.
ApplicationsWesternblot0.5-1.0ug/mL;detectsabandat~17kDaforthematuremouseform.Insomeinstancestheproformat~30kDacanalsobedetected.Thisantibodydoesnotfunctionforimmunohistochemistry.
SpecificityMouse,otherspeciesnotyettested.Theantibodymayalsoreactwithratduetosequencehomology.
SpeciesAgainstMouse
AntibodyAgainstMouse
Cross-reactivityOtherspeciesnotyettested
Formaffinitypurified
Appearancelyophilized
ReconstitutionReconstitutewith200uLofdistilledwater,finalconcentration0.5mg/mL
StorageAt2-8degCforoneyear(lyophilized).Afterreconstitutionaliquotandstorefrozenat-20degCforuptosixmonths.Avoidrepeatedfreezingandthawing.
品牌介绍

Biosensis专注于神经科学领域的抗体和试剂的开发,特别是神经营养因子和神经营养因子受体。 近30年来,Biosensis一直是该领域的全球领航者和OEM供应商。除神经营养因子,我们的神经科学产品组合还被广泛用于神经退行性疾病、神经发育和神经代谢的研究。重点研究领域包括阿尔茨海默氏症(AD)、帕金森氏症(PD)和肌萎缩侧索硬化(ALS)疾病,以及自噬和代谢应激障碍,包括肥胖、代谢综合征的研究、神经免疫学和炎症。

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