Biosensis/Mouse monoclonal antibody to rh BDNF [3C11]: IgG/M-1736-100/100 µg. <b> Supplied as 2 x 50 µg vials.</b>,Biosensis,,Biosensis,Biosensis inc,+,,Array.Array.Array蚂蚁淘厂家直采.

产品名称：Biosensis/Mouse monoclonal antibody to rh BDNF [3C11]: IgG/M-1736-100/100 µg. Supplied as 2 x 50 µg vials.

产品编号：M-1736-100

市场价：¥7340.00

场地：美国(厂家直采)

产品分类：抗体类>一抗>功能性抗体>

联系QQ：1570468124

电话号码：4000-520-616

邮箱： info@ebiomall.com

美元价：$367.00

品牌： Biosensis

公司：Biosensis

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商品介绍

Description	BDNF belongs to the neurotrophin family and promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it. It is a major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability. The alterations in BDNF expression induced by various kinds of brain insult including stress, ischemia, seizure activity and hypoglycemia, may contribute to some pathologies such as depression, epilepsy, Alzheimer's, and Parkinson's disease. Microglia release BDNF that may contribute to neuroinflammation and neuropathic pain. SUBUNIT: Monomers and homodimers. Binds to NTRK2/TRKB. SUBCELLULAR LOCATION: Secreted protein. POst translation modification: Converted into mature BDNF by plasmin (PLG). SIMILARITY: Belongs to the NGF-beta family.
Related products	Available as 50 µg.
Batch No.	See product label.
Unit size	100 µg. Supplied as 2 x 50 µg vials.
Antigen	Recombinant human mature BDNF expressed in E.coli
Antibody Type	Mouse monoclonal.
Clone	3C11
Other Names	Brain-derived neurotrophic factor; Abrineurin; proBDNF
Accession	BDNF_HUMAN
Produced in	Mouse
Molecular Weight	Mature BDNF dimer has a molecular weight of 28 kDa. In Western Blotting, mature BDNF monomer migrates at 14 kDa.
Purity	Protein G purified mouse IgG.
Applications	ELISA (50-100 ng/mL), WB (0.2 to 2 µg/mL), IF (2 to 20 µg/mL). Biosensis recommends optimal dilutions/concentrations should be determined by the end user.
Specificity	Detects human, mouse, rat, guinea pig BDNF. Expected to detect BDNF from other species due to sequence homology.
Blast URL	Click here
Form	Lyophilized from a solution containing PBS pH 7.4, 3% trehalose, with 0.1% sodium azide.
Reconstitution	Spin vial briefly before opening. Reconstitute each vial with 50 µL sterile water to obtain a concentration of 1 mg/mL.
Storage	Store lyophilized antibody at -20°C to -80°C protected from moisture. After reconstitution divide antibody into useful aliquots and keep aliquots at -20°C to -80°C for a higher stability. Working aliquots can be kept at 2-8°C for up to 1 month. Avoid repetitive freeze/thaw cycles.
Expiry Date	12 months after purchase if unopened.
General References	Chacon-Fernandez P et al. (2016), Brain-derived Neurotrophic Factor in Megakaryocytes. J Biol Chem. 2016 May 6; 291(19): 98729881. Species: Human. Application: WB, IF.

品牌介绍

Biosensis专注于神经科学领域的抗体和试剂的开发，特别是神经营养因子和神经营养因子受体。 近30年来，Biosensis一直是该领域的全球领航者和OEM供应商。除神经营养因子，我们的神经科学产品组合还被广泛用于神经退行性疾病、神经发育和神经代谢的研究。重点研究领域包括阿尔茨海默氏症（AD）、帕金森氏症（PD）和肌萎缩侧索硬化（ALS）疾病，以及自噬和代谢应激障碍，包括肥胖、代谢综合征的研究、神经免疫学和炎症。

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