Description | FUNCTION:ThisisareceptorforthetachykininneuropeptideneuromedinK(neurokininB).ItisassociatedwithGproteinsthatactivateaphosphatidylinositol-calciumsecondmessengersystem.SUBCELLULARLOCATION:Membrane;multi-passmembraneprotein.PTM:Theanchoringofthisreceptortotheplasmamembraneisprobablymediatedbythepalmitoylationofacysteineresidue.MISCELLANEOUS:Therankorderofaffinityofthisreceptortotachykininsis:neuromedinK>substanceK>substanceP.SIMILARITY:BelongstotheG-proteincoupledreceptor1family. |
BatchNo. | Seeproductlabel |
Unitsize | 100µl |
Antigen | Asyntheticpeptide(ASTTSSFISSPYTSVDEYS)correspondingtotheabsoluteC-terminalofratNK-3receptorprotein(aa:434-452)conjugatedtoKLH |
OtherNames | NeuromedinKreceptor;NKR;NeurokininBreceptor;NK-3receptor;NK-3R;Tachykininreceptor3;Tacr3;Tac3r |
Accession | NK3R_RAT |
Producedin | Rabbit |
Purity | Wholeserum |
Applications | WB.Adilutionof1:500to1:2000isrecommended.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser. |
Specificity | Specificityhasbeenshownbywesternblotusingratbrainhomogenate.Abandof66kDa,thetheoreticalMWofNK-3R,couldbeeasilydetected. |
Cross-reactivity | ThisantiserumisknowtocrossreactwithratNK-3R. |
Blastit | Ifyouwouldliketousethisproductinanotherspeciesotherthanthosespecifiedhere,ortoseethesharedIDbetweentheimmunogenusedhereindifferentspeicesand/orothermolecules,simplycopytheimmunogen(fromtheImmunogenfield)andpasteitHEREandblast/formatit.Notethat,antiseraraisedagainstsyntheticpeptidesarequiteoftenveryspecificforthatpeptideie,onlyonesingleaminoaciddifferencemaybeenoughtorestrictthespecificitytoaparticularmolecule.Regardless,youcanalwayscontactusifyouneedassistancewiththis. |
Form | Lyophilised |
Reconstitution | Reconstitutein100µlofsterilewater.Centrifugetoremoveanyinsolublematerial. |
Storage | Afterreconstitutionkeepaliquotsat-20ºCforahigherstABIlity,andat4ºCwithanappropriateantibacterialagent.Glycerol(1:1)maybeaddedforanadditionalstability.Avoidrepetitivefreeze/thawcycles. |
References | Mileusnic,D.etal.(1999).Neuroscience.89(4):1269. |
Biosensis专注于神经科学领域的抗体和试剂的开发,特别是神经营养因子和神经营养因子受体。 近30年来,Biosensis一直是该领域的全球领航者和OEM供应商。除神经营养因子,我们的神经科学产品组合还被广泛用于神经退行性疾病、神经发育和神经代谢的研究。重点研究领域包括阿尔茨海默氏症(AD)、帕金森氏症(PD)和肌萎缩侧索硬化(ALS)疾病,以及自噬和代谢应激障碍,包括肥胖、代谢综合征的研究、神经免疫学和炎症。