Description | C-reactiveproteinhasseveralrolesassociatedwithhostdefencesuchas;promotingagglutination,bacterialcapsularswelling,phagocytosisandcomplementfixationthroughitscalcium-dependentbindingtophosphorylcholine.ItcaninteractwithDNAandhistonesandmayscavengenuclearmaterialreleasedfromdamagedcirculatingcells.COFACTOR:Binds2calciumionspersubunit.C-reactiveproteinexistsasahomopentamer.Pentaxin(orPentraxin)haveadiscoidarrangementof5non-covalentlyboundsubunits.Thereare2alternativelysplicedisoforms.C-reactiveproteinisfoundinplasmaanditsconcentrationincreasesgreatlyduringacutephaseresponsetotissueinjury,infectionorotherinflammatorystimuli.ItisinducedbyIL-1andIL-6. |
BatchNo. | Seeproductlabel |
Unitsize | 100µl |
Antigen | HumanrecombinantC-Reactiveprotein |
OtherNames | CRP;PTX1 |
Accession | CRP_HUMAN |
Producedin | Sheep |
Purity | Wholeserum |
Applications | WB.Extremelyhightitreantibody.Forwesternblotadilutionof1:10,000to1:100000isrecommended.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser. |
Specificity | IthasbeenshowntobespecificforC-reactiveproteinbyWB. |
Cross-reactivity | Human,otherspecieshavenotyetbeentested. |
Blastit | IfyouwouldliketoseethesharedidentitybetweendifferentspeciesorotherproteinsfollowthelinkinAccessionfield,selectthenthesequence(makesurethatyouareselectingthesequencethatyouareinterestedin,asthesequencemaybetheprecursorratherthanthematureproteinforexample)andcopyandpasteitHEREandblast/formatit. |
Form | Lyophilisedwith0.01%Thimerosal |
Reconstitution | Reconstitutein100µlofsterilewater.Centrifugetoremoveanyinsolublematerial. |
Storage | Afterreconstitutionkeepaliquotsat-20ºCforahigherstABIlity,andat4ºCwithanappropriateantibacterialagent. |
ExpiryDate | 12monthsafterpurchase |
References | 1.LeiK.-J,etal.J.Biol.Chem.260:13377-13383(1985). 2.WooP,etal.J.Biol.Chem.260:13384-13388(1985). |
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