商品介绍
| Description | FUNCTION:Receptorforbrain-derivedneurotrophicfactor(BDNF),neurotrophin-3andneurotrophin-4/5butnotnervegrowthfactor(NGF).Involvedinthedevelopmentand/ormaintenanceofthenervoussystem.Thisisatyrosine-proteinkinasereceptor.KnownsubstratesfortheTRKreceptorsareSHC1,PI-3kinase,andPLC-gamma-1.CATALYTICACTIVITY:ATP+a[protein]-L-tyrosine=ADP+a[protein]-L-tyrosinephosphate.SUBUNIT:Existsinadynamicequilibriumbetweenmonomeric(lowaffinity)anddimeric(highaffinity)structures(Bysimilarity).BindsAPS.InteractswithSQSTM1.SUBCELLULARLOCATION:Membrane;single-passtypeImembraneprotein.ALTERNATIVEPRODUCTS:3namedisoformsproducedbyalternativesplicing.Additionalisoformsseemtoexist.TISSUESPECIFICITY:Thedifferentformsaredifferentiallyexpressedinvariouscelltypes.IsoformT2isprimarilyexpressedinneurons.PTM:Ligand-mediatedauto-phosphorylation.SIMILARITY:BelongstotheTyrproteinkinasefamily.Insulinreceptorsubfamily.SIMILARITY:Contains2Ig-likeC2-type(immunoglobulin-like)domains.SIMILARITY:Contains2LRR(leucine-rich)repeats.SIMILARITY:Contains1proteinkinasedomain. |
| Relatedproducts | TrkBcontrolpeptide(aa:23-36),PE-1252-100 |
| BatchNo. | Seeproductlabel |
| Unitsize | 100µl |
| Antigen | Asyntheticpeptide(AFPRLEPNSIDPENC)aspartofratmatureTrkBprotein(aa:23-36)conjugatedtoKLH |
| OtherNames | Tropomyosin-relatedkinasereceptor;BDNF/NT-3growthfactorsreceptor;Neurotrophictyrosinekinasereceptortype2;TrkBtyrosinekinase;GP145-TrkB/GP95-TrkB;Trk-B;Ntrk2;Trkb |
| Accession | NTRK2_RAT |
| Producedin | Rabbit |
| Purity | Wholeserum |
| Applications | IHC.Adilutionof1:1000to1:3000isrecommendedforthisapplication.ForWB,a1:500to1:1000dilutionisrecommended.ThesequenceoftheimmunogenandtheconjugateareidenticaltotheoneusedbyYanetal(seetheRefs)andtheantiserumappearstohavesimilarcharacteristics.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser. |
| Specificity | SequencewaschosentoavoidcrossreactivitywithTrkAandTrkC. |
| Cross-reactivity | Thisantiserumrecogniseshuman,ratandmouseTrkB.Crossreactivitywithotherspecieshasnotyetbeentested. |
| Blastit | Ifyouwouldliketousethisproductinanotherspeciesotherthanthosespecifiedhere,ortoseethesharedidentitybetweentheimmunogenusedhereindifferentspeicesand/orothermolecules,simplycopytheimmunogen(fromtheImmunogenfield)andpasteitHEREandblast/formatit.Notethat,antiseraraisedagainstsyntheticpeptidesarequiteoftenveryspecificforthatpeptideie,onlyonesingleaminoaciddifferencemaybeenoughtorestrictthespecificitytoaparticularmolecule.Regardless,youcanalwayscontactusifyouneedassistancewiththis. |
| Form | Lyophilised |
| Reconstitution | Reconstitutein100µlofsterilewater.Centrifugetoremoveanyinsolublematerial. |
| Storage | Afterreconstitutionkeepaliquotsat-20ºCforahigherstABIlity,andat4ºCwithanappropriateantibacterialagent.Glycerol(1:1)maybeaddedforanadditionalstability.Avoidrepetitivefreeze/thawcycles. |
| ExpiryDate | 12monthsafterpurchase |
| SpecificReferences | WangT,MartinS,NguyenTH,HarperCB,GormalRS,Martínez-MármolR,KarunanithiS,CoulsonEJ,GlassNR,Cooper-WhiteJJ,vanSwinderenB,MeunierFA.(2016)"FluxofsignallingendosomesundergoingaxonalretrogradetransportisencodedbypresynapticactivityandTrkB."NatCommun.2016Sep.PMID:2768712930(7):12976.Application:IF&structuredIlluminationmicroscopy(SIM).Species:Rat,Mouse;fixed4%PFAwith4%sucrose MatusicaDetal(2016)Inhibitionofmotorneurondeathinvitroandinvivobyap75neurotrophinreceptorintracellulardomainfragment.JCellSci.2016Feb1;129(3):517-30.Application:WB. BrockJHetal(2010)Localandremotegrowthfactoreffectsafterprimatespinalcordinjury.JNeurosci.2010Jul21;30(29):9728-37. GruberH.etal(2008)Brain-derivedneurotrophicfactoranditsreceptorinthehumanandthesandratintervertebraldisc.ArthritisResTher.2008;10(4):R82. |
| References | 1.YanQetal.JCompNeurol378:135-57(1997). 2.Stoilov,P.,etal.,Biochem.Biophys.Res.Commun.290(3):1054-1065(2002). 3.Strausberg,R.L.,etal.,Proc.Natl.Acad.Sci.U.S.A.99(26):16899-16903(2002). 4.Nakagawara,A.,etal.,Genomics25(2):538-546(1995). 5.Haniu,M.,etal.,Arch.Biochem.Biophys.322(1):256-264(1995). 6.Allen,S.J.,etal.,Neuroscience60(3):825-834(1994). 7.MizoguchiYetal.,JImmunol.2009Dec15;183(12):7778-86. 8.Spencer-SegalJLetal.JNeurosci.2011May4;31(18):6780-90. 9.NakajimaKetal.Glia.1998Nov;24(3):272-89. |
品牌介绍
Biosensis专注于神经科学领域的抗体和试剂的开发，特别是神经营养因子和神经营养因子受体。 近30年来，Biosensis一直是该领域的全球领航者和OEM供应商。除神经营养因子，我们的神经科学产品组合还被广泛用于神经退行性疾病、神经发育和神经代谢的研究。重点研究领域包括阿尔茨海默氏症（AD）、帕金森氏症（PD）和肌萎缩侧索硬化（ALS）疾病，以及自噬和代谢应激障碍，包括肥胖、代谢综合征的研究、神经免疫学和炎症。
公司介绍
产品分类
TR-200-BG
PE-1243-50
Antibody Kits
PE-1246-5
TR-100-BG
S-1754-500
Neurotrophic Factors
Diabetes & Obesity
Intracellular Trafficking
PE-1239-5
Neuropeptides & Receptors
B-100-PS
Receptors & Channel Molecules
2 Plate ELISA kits
M-1763-100-FT
TR-200-BGT
PE-1239-2
PE-1242-5
M-1249-100
Neurotrophic Factor Receptors
Cell Cycle Regulators
S-1759-100
PE-1606-100
PE-1762-100
B-200-PS
PE-019-100
PE-1241-5
PE-003-100
1 Plate ELISA kits
BL-003-1000
PE-1246-2
Sensory Nervous System
PE-1253-100
TR-100-FJ
BL-005-500
Neuroendocrine
M-1728-100
DNA Damage & Repair
PE-001-100
PE-1608-1
TR-400-AG
PE-1243-25
Cell Markers
PE-1608-5
TR-100-FJT
Autophagy
PE-1242-2
Other Neuronal
Neurotransmitters & Enzymes
Antioxidant Enzymes
Neuronal Markers
Tag Antibodies
BL-004-500
PE-019-25
PE-1608-10
BL-002-1250
Receptor Body Chimeras
Signalling & Transcription
Matrix & Adhesion Molecules
BL-001-1250
Cancer
PE-019-500
Stem Cells
Junction Proteins
TR-300-AG
Apoptosis
PE-1252-100
Growth Factors
Development
Alzheimer\'s / Parkinson\'s
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