商品介绍
| Description | FUNCTION:Neuropeptidesthatplayasignificantroleintheregulationoffoodintakeandsleep-wakefulness,possIBLybycoordinatingthecomplexbehavioralandphysiologicresponsesofthesecomplementaryhomeostaticfunctions.Abroaderroleinthehomeostaticregulationofenergymetabolism,autonomicfunction,hormonalbalanceandtheregulationofbodyfluids,isalsosuggested.Orexin-AbindstobothOX1RandOX2Rwithahighaffinity,whereasorexin-BbindsonlytoOX2Rwithasimilarhighaffinity.SUBCELLULARLOCATION:Endoplasmicreticulum;roughendoplasmicreticulum.Associatedwithperikaryalroughendoplasmicreticulumaswellascytoplasmiclargegranularvesiclesatsynapses.SIMILARITY:Belongstotheorexinfamily. |
| BatchNo. | Seeproductlabel |
| Unitsize | 100µl |
| Antigen | Asyntheticpeptide(CRLYELLHGAGNHAAGILTL)aspartofBovineOrexinA(aa:14-33)conjugatedtoKLHhasbeenusedastheimmunogen. |
| AntigenLocation | 14-33aa |
| OtherNames | Orexin-A;Hypocretin-1;Hcrt1 |
| Accession | OREX_BOVIN |
| Producedin | Rabbit |
| Purity | Wholeserum |
| Applications | IHC.ThisisasuperbantiserumforimmunohistochemistryonOrexinAcontainingneuronsexhibitingintenselabellingofneuronswithverylowbackground.Adilutionof1:1000to1:2000isrecommendedforthisapplication.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser. |
| Specificity | Thespecificityforthisantiserumhasbeenconfirmedbyimmunohistochemistryonratbrainandtheresultsreflectthecurrentliterature. |
| Cross-reactivity | ThisantibodyisknowntoreactwithratOrexinA. |
| Blastit | Ifyouwouldliketousethisproductinanotherspeciesotherthanthosespecifiedhere,ortoseethesharedIDbetweentheimmunogenusedhereindifferentspeciesand/orothermolecules,simplycopytheimmunogen(fromtheImmunogenfield)andpasteitHEREandblast/formatit.Notethat,antiseraraisedagainstsyntheticpeptidesarequiteoftenveryspecificforthatpeptideie,onlyonesingleaminoaciddifferencemaybeenoughtorestrictthespecificitytoaparticularmolecule.Regardless,youcanalwayscontactusifyouneedassistancewiththis. |
| Form | Lyophilised |
| Reconstitution | Reconstitutein100µlofsterilewater.Centrifugetoremoveanyinsolublematerial. |
| Storage | Afterreconstitutionkeepaliquotsat-20ºCforahigherstABIlity,andat4ºCwithanappropriateantibacterialagent.Glycerol(1:1)maybeaddedforanadditionalstability.Avoidrepetitivefreeze/thawcycles. |
| ExpiryDate | 12monthsafterpurchase |
| SpecificReferences | 1.KrugerJ.L.etal(2010)Cellularlocationandmajorterminalnetworksoftheorexinergicsysteminthebrainsoffivemicrochiropteranspecies.JChemNeuroanat.2010Nov;40(3):256-62. 2.GaykemaR.P.etal(2009)Lipopolysaccharidechallenge-inducedsuppressionofFosinhypothalamicorexinneurons:theirpotentialroleinsicknessbehavior.BrainBehavImmun.2009Oct;23(7):926-30. 3.LeeH.S.etal(2005)Retrogradestudyofhypocretin-1(orexin-A)projectionstosuBDivisionsofthedorsalraphenucleusintherat.BrainRes.2005Oct12;1059(1):35-45. 4.YaoS.T.etal(2005)Waterdeprivationincreasestheexpressionofneuronalnitricoxidesynthase(nNOS)butnotorexin-Ainthelateralhypothalamicareaoftherat.JCompNeurol.2005Sep19;490(2):180-93. |
| References | Nambu,T.etal.(1999)BrainResearch.827:243-60 |
品牌介绍
Biosensis专注于神经科学领域的抗体和试剂的开发，特别是神经营养因子和神经营养因子受体。 近30年来，Biosensis一直是该领域的全球领航者和OEM供应商。除神经营养因子，我们的神经科学产品组合还被广泛用于神经退行性疾病、神经发育和神经代谢的研究。重点研究领域包括阿尔茨海默氏症（AD）、帕金森氏症（PD）和肌萎缩侧索硬化（ALS）疾病，以及自噬和代谢应激障碍，包括肥胖、代谢综合征的研究、神经免疫学和炎症。
公司介绍
产品分类
TR-200-BG
PE-1243-50
Antibody Kits
PE-1246-5
TR-100-BG
S-1754-500
Neurotrophic Factors
Diabetes & Obesity
Intracellular Trafficking
PE-1239-5
Neuropeptides & Receptors
B-100-PS
Receptors & Channel Molecules
2 Plate ELISA kits
M-1763-100-FT
TR-200-BGT
PE-1239-2
PE-1242-5
M-1249-100
Neurotrophic Factor Receptors
Cell Cycle Regulators
S-1759-100
PE-1606-100
PE-1762-100
B-200-PS
PE-019-100
PE-1241-5
PE-003-100
1 Plate ELISA kits
BL-003-1000
PE-1246-2
Sensory Nervous System
PE-1253-100
TR-100-FJ
BL-005-500
Neuroendocrine
M-1728-100
DNA Damage & Repair
PE-001-100
PE-1608-1
TR-400-AG
PE-1243-25
Cell Markers
PE-1608-5
TR-100-FJT
Autophagy
PE-1242-2
Other Neuronal
Neurotransmitters & Enzymes
Antioxidant Enzymes
Neuronal Markers
Tag Antibodies
BL-004-500
PE-019-25
PE-1608-10
BL-002-1250
Receptor Body Chimeras
Signalling & Transcription
Matrix & Adhesion Molecules
BL-001-1250
Cancer
PE-019-500
Stem Cells
Junction Proteins
TR-300-AG
Apoptosis
PE-1252-100
Growth Factors
Development
Alzheimer\'s / Parkinson\'s
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