Description | IthasbeendemonstratedthatTrpC1andTrpC5aresubunitsofaheteromericneuronalchannelinmammalianbrain.TrpC5isthoughttoformareceptor-activatdnon-selectivepermeantcationchannel.ItisprobablyoperatedbyaphosphatidylinositolsecondmessengersystemactivatedbyreceptorkinasesorG-proteincoupledreceptors.Ithasalsobeenshowntobecalcium-selectiveanditmaybealsoactivatedbyintracellularcalciumstoredepletion.TrpC5proteinwasshowntobepresentinhippocampalneuronalgrowthcones,neuronalcellbodies,areasconsistentwithnewsynapseformation,andcytoplasmictransportvesiclesalongneuronalprocesses.TrpC5isexpressedinbrainwithhigherlevelsinfetalbrain.Influxesofcalciumviavoltage-gatedchannelsplayaroleinneuronaloutgrowthanditwassuggestedthatTrpC5isacandidatefortheregulationofcalciumwaves. |
BatchNo. | Seeproductlabel |
Unitsize | 50µl |
Antigen | PartialrecombinanthumanTrpC5[534-603]withaGSTtag. |
OtherNames | Shorttransientreceptorpotentialchannel5;Htrp-5;Htrp5;TRPC5;TRP5 |
Accession | TRPC5_HUMAN |
Producedin | Mouse |
Applications | ThisantibodyisrecommendedforWBandELISA.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser. |
Specificity | SpecificityhasbeenconfirmedbyELISAagainsttheantigen. |
Cross-reactivity | Human.Otherspecieshavenotbeentested. |
Blastit | Toseethesharedidentitybetweendifferentspeciesorotherproteins,followthelinkintheAccessionfield,selectthesequencethatyouareinterestedinandcopyandpasteitHEREandblast/formatit. |
Form | Liquid.Storagebuffer:50%glycerol |
Storage | Keepaliquotsstoredat-20ºCforhigherstABIlity.Avoidrepetitivefreeze/thawcycles. |
ExpiryDate | 12monthsafterpurchase |
Biosensis专注于神经科学领域的抗体和试剂的开发,特别是神经营养因子和神经营养因子受体。 近30年来,Biosensis一直是该领域的全球领航者和OEM供应商。除神经营养因子,我们的神经科学产品组合还被广泛用于神经退行性疾病、神经发育和神经代谢的研究。重点研究领域包括阿尔茨海默氏症(AD)、帕金森氏症(PD)和肌萎缩侧索硬化(ALS)疾病,以及自噬和代谢应激障碍,包括肥胖、代谢综合征的研究、神经免疫学和炎症。