Description | Proteinkinaseminibrainhomologphosphorylatesserine,threonineandtyrosineresiduesinitssequenceaswellasinexogenoussubstrates.Itmayplayasignificantroleinasignalingpathwayregulatingcellproliferationandmaybeinvolvedinbraindevelopment.Thereare5namedisoformsproducedbyalternativesplicing.Itisexpressedubiquitouslywithhighestlevelsinskeletalmuscle,testis,fetallungandkidney,andinthedevelopingcentralnervoussystem.Itlocalisestothenucleusspeckle.Thisproteinisoverexpressed1.5-foldinfetalDownsyndromebrainandconsideredastrongcandidateforlearningdefectsassociatedwithDownsyndrome.Itbelongstotheproteinkinasesuperfamily,CMGCser/ThrproteinkinasefamilyandMNB/DYRKsubfamilly. |
BatchNo. | Seeproductlabel |
Unitsize | 100µg |
Antigen | Partialrecombinantproteinofhumanproteinkinaseminibrainhomolog(aa674to763)withaGSTtag. |
Clone | 7D10 |
OtherNames | Dualspecificitytyrosine-phosphorylation-regulatedkinase1A;MNBH;HP86;DualspecificityYAK1-relatedkinase;hMNB;DYRK1A |
Accession | DYR1A_HUMAN |
Producedin | Mouse |
Purity | ProteinGpurifiedimmunoglobulin |
Applications | DirectandsandwichELISAandWBarerecommendedforthisantibody.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser. |
Specificity | SpecificityhasbeenconfirmedbyWBanddirectELISAagainsttheantigen. |
Cross-reactivity | Thisantibodycrossreactswithmouseandratproteinkinaseminibrainhomologproteins. |
Blastit | Toseethesharedidentitybetweendifferentspeciesorotherproteins,followthelinkintheAccessionfield,selectthesequencethatyouareinterestedinandcopyandpasteitHEREandblast/formatit. |
Form | LyophilisedfromPBSpH7.2 |
Reconstitution | Reconstitutein100µlofsterilewater.Centrifugetoremoveanyinsolublematerial. |
Storage | Afterreconstitutionkeepaliquotsat-20°CforhigherstABIlityorat4°Cwithanappropriateantibacterialagent.Glycerol(1:1)maybeaddedforadditionalstability.Avoidrepetitivefreeze/thawcycles. |
ExpiryDate | 12monthswhenstoredat-20°C |
Biosensis专注于神经科学领域的抗体和试剂的开发,特别是神经营养因子和神经营养因子受体。 近30年来,Biosensis一直是该领域的全球领航者和OEM供应商。除神经营养因子,我们的神经科学产品组合还被广泛用于神经退行性疾病、神经发育和神经代谢的研究。重点研究领域包括阿尔茨海默氏症(AD)、帕金森氏症(PD)和肌萎缩侧索硬化(ALS)疾病,以及自噬和代谢应激障碍,包括肥胖、代谢综合征的研究、神经免疫学和炎症。