产品编号：M-1752-100
市 场 价：¥5940.00
场 地：美国(厂家直采)
联系QQ：1570468124
电话号码：4000-520-616
邮 箱：
info@ebiomall.com
商品介绍
| Description | FUNCTION:Nuclearphosphoproteinwhichformsatightbutnon-covalentlylinkedcomplexwiththeJUN/AP-1transcriptionfactor.Intheheterodimer,FOSandJUN/AP-1basicregionseachseemstointeractwithsymmetricalDNAhalfsites.OnTGF-betaactivation,formsamultimericSMAD3/SMAD4/JUN/FOScomplexattheAP1/SMAD-bindingsitetoregulateTGF-beta-mediatedsignaling.Hasacriticalfunctioninregulatingthedevelopmentofcellsdestinedtoformandmaintaintheskeleton.Itisthoughttohaveanimportantroleinsignaltransduction,cellproliferationanddifferentiation.Ingrowingcells,activatesphospholipidsynthesis,possIBLybyactivatingCDS1andPI4K2A.ThisactivityrequiresTyr-dephosphorylationandassociationwiththeendoplasmicreticulum.SUBUNIT:Heterodimer.InteractswithDSIPI;thisinteractioninhibitsthebindingofactiveAP1toitstargetDNA.InteractswithMAFB.SUBCELLULARLOCATION:Nucleus.INDUCTION:C-fosexpressionincreasesuponavarietyofstimuli,includinggrowthfactors,cytokines,neurotransmitters,polypeptidehormones,stressandcellinjury.SIMILARITY:BelongstothebZIPfamily.Fossubfamily.SIMILARITY:Contains1bZIPdomain(Ref:uniprot.org). |
| BatchNo. | Seeproductlabel. |
| Unitsize | 100µg |
| Antigen | Fulllength,E.coli-derivedrecombinanthumanc-FOSprotein. |
| AntibodyType | Monoclonal |
| Isotype | IgG1 |
| OtherNames | Cellularoncogenefos;G0/G1switchregulatoryprotein7;cFOS |
| Accession | FOS_HUMAN |
| Producedin | Mouse. |
| Purity | Affinitypurified. |
| Applications | Immunohistochemistry(IHC)andimmunocytochemistry(ICC):1-2µg/mL.Thisantibodyhasbeenshowntoworkon4%PFAfixedmousebrainsections. Westernblotting(WB):0.5-1.0µg/mL.Thisantibodydetectsbandsbetween50-65kDa,whichonlyappearinstimulatedcells. Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser. |
| Specificity | Human. |
| Cross-reactivity | Horse,cow,pig,chicken,rat,mouse. |
| BlastURL | Clickhere |
| Form | Lyophilizedfromasolutioncontaining3%trehaloseinPBS,pH7.4,withoutpreservatives. |
| Reconstitution | Reconstitutewith100µLsterile-filtered,ultrapurewater,toachieveanantibodyconcentrationof1mg/mL.Centrifugebrieflytoremoveanyinsolublematerial. |
| Storage | Storelyophilised,unopenedvialat2-8°Corlower.Afterreconstitution,preparealiquotsandstoreat-20°CforahigherstABIlity.Avoidfreeze-thawcycles. |
| ExpiryDate | 12monthsafterpurchaseifunopenedandstoredasindicated. |
| GeneralReferences | VanstrAATenetal(1983)Proc.Natl.Acad.Sci.80:3183(Originalmolecularc-fossequencepaper) MinsonJ.etal.(1994)BrainRes.646:44-52(EarlyIHClocalizationpaper) |
品牌介绍
Biosensis专注于神经科学领域的抗体和试剂的开发，特别是神经营养因子和神经营养因子受体。 近30年来，Biosensis一直是该领域的全球领航者和OEM供应商。除神经营养因子，我们的神经科学产品组合还被广泛用于神经退行性疾病、神经发育和神经代谢的研究。重点研究领域包括阿尔茨海默氏症（AD）、帕金森氏症（PD）和肌萎缩侧索硬化（ALS）疾病，以及自噬和代谢应激障碍，包括肥胖、代谢综合征的研究、神经免疫学和炎症。
公司介绍
产品分类
TR-200-BG
PE-1243-50
Antibody Kits
PE-1246-5
TR-100-BG
S-1754-500
Neurotrophic Factors
Diabetes & Obesity
Intracellular Trafficking
PE-1239-5
Neuropeptides & Receptors
B-100-PS
Receptors & Channel Molecules
2 Plate ELISA kits
M-1763-100-FT
TR-200-BGT
PE-1239-2
PE-1242-5
M-1249-100
Neurotrophic Factor Receptors
Cell Cycle Regulators
S-1759-100
PE-1606-100
PE-1762-100
B-200-PS
PE-019-100
PE-1241-5
PE-003-100
1 Plate ELISA kits
BL-003-1000
PE-1246-2
Sensory Nervous System
PE-1253-100
TR-100-FJ
BL-005-500
Neuroendocrine
M-1728-100
DNA Damage & Repair
PE-001-100
PE-1608-1
TR-400-AG
PE-1243-25
Cell Markers
PE-1608-5
TR-100-FJT
Autophagy
PE-1242-2
Other Neuronal
Neurotransmitters & Enzymes
Antioxidant Enzymes
Neuronal Markers
Tag Antibodies
BL-004-500
PE-019-25
PE-1608-10
BL-002-1250
Receptor Body Chimeras
Signalling & Transcription
Matrix & Adhesion Molecules
BL-001-1250
Cancer
PE-019-500
Stem Cells
Junction Proteins
TR-300-AG
Apoptosis
PE-1252-100
Growth Factors
Development
Alzheimer\'s / Parkinson\'s
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