| Description | Thejagged1proteinencodedbyJAG1isthehumanhomologoftheDrosophiliajaggedprotein.Humanjagged1istheligandformultipleNotchreceptorsinvolvedinthemediationofNotchsignalling.Itmaybeinvolvedincell-fatedecisionduringhematopoiesisandseemstobeinvolvedinearlyandlatestagesofmammaliancardiovasculardevelopment.JAG1isatransmembraneproteinthatiswidelyexpressedinadultandfetaltissues.Mutationsthatalterthejagged1proteincauseAlagillesyndromewhichisanautosomaldominantmultisysstemdisorder.DefectsinJAG1arealsothecauseoftetralogyofFallot(TOF)whichisacongenitalheartanomaly. |
| BatchNo. | Seeproductlabel |
| Unitsize | 200µl |
| Antigen | PartialrecombinanthumanJAG1(aminoacids531-621)withaGSTtag |
| Clone | [1E12] |
| OtherNames | Proteinjagged-1;Jagged1;hJ1;CD339antigen;JAG1;JAGL1; |
| Accession | JAG1_HUMAN |
| Producedin | Mouse |
| Purity | Ascitesfluid |
| Applications | ThisantibodyisrecommendedfordirectELISAandWB.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser. |
| Specificity | SpecificitywasdemonstratedbyWBagainsttheantigen. |
| Cross-reactivity | Human.Otherspeciesnotyettested. |
| Blastit | Toseethesharedidentitybetweendifferentspeciesorotherproteins,followthelinkintheAccessionfield,selectthesequencethatyouareinterestedinandcopyandpasteitHEREandblast/formatit. |
| Form | Lyophilised |
| Reconstitution | Reconstitutein200µlofsterilewater.Centrifugetoremoveanyinsolublematerial. |
| Storage | Afterreconstitutionkeepaliquotsat-20ºCforhigherstABIlityorat4ºCwithanappropriateantibacterialagent.Glycerol(1:1)maybeaddedforadditionalstability.Avoidrepetitivefreeze/thawcycles. |
| ExpiryDate | 12monthsafterpurchase |
Biosensis专注于神经科学领域的抗体和试剂的开发,特别是神经营养因子和神经营养因子受体。 近30年来,Biosensis一直是该领域的全球领航者和OEM供应商。除神经营养因子,我们的神经科学产品组合还被广泛用于神经退行性疾病、神经发育和神经代谢的研究。重点研究领域包括阿尔茨海默氏症(AD)、帕金森氏症(PD)和肌萎缩侧索硬化(ALS)疾病,以及自噬和代谢应激障碍,包括肥胖、代谢综合征的研究、神经免疫学和炎症。



