Description | TheT-cellreceptor-CD3complex(CD3-TCR)playsanimportantroleinmediatingsignalingtransduction.TheCD3-TCRcomplexconsistsofeitheraTCRalpha/betaorTCRgamma/deltaheterodimerco-expressedatthecellsurfacewiththeCD3subunits:CD3gamma,CD3delta,CD3epsilonandCD3zeta.Thesesubunitsaresingle-passtypeImembraneproteinsexpressedonnormalperipheralbloodlymphocytes,thymocytesandPurkinjecellsinthecerebellum. |
BatchNo. | Seeproductlabel |
Unitsize | 100µg |
Antigen | HumanthymocytesfollowedbySezaryTcells |
Clone | CA-3 |
OtherNames | T-cellsurfaceglycoproteinCD3;CD3E;CD3G;CD3H;CD3Q;CD3Z;TcellreceptorT3; |
Accession | P04234CD3D_HUMAN;P07766CD3E_HUMAN; |
Producedin | Mouse |
Purity | IgG |
Applications | Immunohistochemistry(IHC-Frozen).Aconcentrationof1.0µg/mlisrecommendedtodetectCD3informalin/acetonefixedtissues.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser. |
Specificity | Thespecificityofthisantibodyhasbeenconfirmedbyimmunohistochemistryagainsttheantigen. |
Cross-reactivity | Human;rat; |
Blastit | Ifyouwishtousethisproductinaspeciesotherthanthosespecifiedhereandwanttodeterminetheaminoacidsequencehomologybetweentheimmunogenandthecorrespondingproteininthatspecies,simplycopytheaminoacidsequenceforthisimmunogenandtestitontheBLASTdatabasethatyoucanaccessthroughthelinkbelow.Pleasenotethatantibodiesraisedagainstsyntheticpeptidesarequiteoftenveryspecificforthatpeptide.Whatthismeansinpracticeisthatasingleaminoaciddifferencemaybeenoughtorestrictthespecificitytoaparticularmolecule.TheBLASTdatabasecanalsobeusedtocompareanyaminoacidsequencebetweenspeciesandbetweenprotein.ThefullaminoacidsequenceofthetargetproteincanbefoundbyfollowingthelinkintheAccessionfield.YoucanthensearchanyaminoacidsequenceinthetargetproteinusingtheBLASTdatabase.Whenselectingasequencetosearch,pleasechoosecarefully,asthesequenceyouchoosemaybeaprecursorratherthanthematureproteinforexample. |
Form | Lyophilizedfrom1.2%sodiumacetate,2mgBSA,0.01mgNaN3 |
Reconstitution | Reconstitutein1mlofPBS(pH7.4)toachieveanantibodyconcentrationof100µg/ml.Centrifugetoremoveanyinsolublematerial. |
Storage | Atleast12monthsafterpurchaseat2-4°C(lyophilizedformulations).Afterreconstitution,aliquotandstoreat-20°CforahigherstABIlity.Avoidfreeze-thawcycles. |
ExpiryDate | 12monthsafterpurchase |
Biosensis专注于神经科学领域的抗体和试剂的开发,特别是神经营养因子和神经营养因子受体。 近30年来,Biosensis一直是该领域的全球领航者和OEM供应商。除神经营养因子,我们的神经科学产品组合还被广泛用于神经退行性疾病、神经发育和神经代谢的研究。重点研究领域包括阿尔茨海默氏症(AD)、帕金森氏症(PD)和肌萎缩侧索硬化(ALS)疾病,以及自噬和代谢应激障碍,包括肥胖、代谢综合征的研究、神经免疫学和炎症。