商品介绍
| Description | Myelinisamembranecharacteristicofthenervoustissueandfunctionsasaninsulatortoincreasethevelocityofthestimulibeingtransmittedbetweenanervecellbodyanditstarget.Myelinisolatedfromhumanandbovinenervoustissueiscomposedofapproximately80%lipidand20%protein,and30%oftheproteinfractionconstitutesmyelinbasicprotein(MBP).MBPisan"intrinsicallyunstructured"proteinwithahighproportion(approximately75%)ofrandomcoil,butpostulatedtohavecoreelementsofbeta-sheetandalpha-helix.MBPisamajorproteininCNSmyelinandisexpressedspecificallyinthenervoussystem.AdetailedimmunochemicalexaminationofmonoclonalandpolyclonalantibodyresponsestoMBPanditspeptideshasrevealedtheexistenceofasmanyas27antigenicdeterminants,manyofthemconformational.TopologicalmappingofthepotentialantigenicdeterminantsontoamodelofMBPsecondarystructureplacesthesedeterminantswithin11separateregionsofthemolecule,includingthoseportionsthathavebeenfoundtobeencephalitogenic.Themessageformyelinbasicproteinisselectivelytranslocatedtotheendsofthecellprocesses.Immunizationwithmyelin-associatedantigensincludingMBPsignificantlypromotesrecoveryafterspinalcordcontusioninjuryintheratmodel.FUNCTION:Is,withPLP,themostabundantproteincomponentofthemyelinmembraneintheCNS.HasaroleinboththeformationandstABIlizationofthiscompactmultilayerarrangementofbilayers.Eachsplicevariantandchargeisomermayhaveaspecializedfunctionintheassemblyofanoptimized,biochemicallyfunctionalmyelinmembrane(Bysimilarity).SUBUNIT:Homodimer(Bysimilarity).SUBCELLULARLOCATION:Myelinmembrane;peripheralmembraneprotein;cytoplasmicside.Cytoplasmicsideofmyelin.TISSUESPECIFICITY:Foundinboththecentralandtheperipheralnervoussystem. |
| BatchNo. | Seeproductlabel |
| Unitsize | 50µl |
| Antigen | ThreepeptidesequencesconservedinhigherverterbrateMBPprotein. |
| Isotype | IgY |
| OtherNames | MyelinBasicProtein;MyelinA1protein;Myelinmembraneencephalitogenicprotein; |
| Accession | P02686MBP_HUMAN; |
| Producedin | Chicken |
| Applications | WesternBlotting(WB),Immunocytochemistry(IC)andImmunohistochemistry(IH).TherecommendeddilutionforWBis1:5,000-10,0000and1:500-1,000forICandIH.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser. |
| Specificity | ThespecificityofthisantibodyhasbeenconfirmedbyWB.Thisantibodystainsaprominentbandatapprox.20kDa.Asuitablecontroltissueisratspinalcordorperipheralnervehomogenate.ThemajorisoformsofMBPrunasacloselyspaceddoubleof22kDaand18kDa. |
| AntibodyAgainst | MyelinBasicProtein |
| Cross-reactivity | Hu,Rat,Ms,Bov.Predictedtoreactwithothermammaliantissuesduetosequencehomology. |
| BlastURL | Clickhere |
| Form | Lyophilisedwith5%trehalose |
| Appearance | Whitepowder |
| Reconstitution | Reconstituteinsteriledistilledwater.Centrifugetoremoveanyinsolublematerial. |
| Storage | Afterreconstitutionoflyophilisedantibody,aliquotandstoreat-20°Cforahigherstability.Avoidfreeze-thawcycles. |
| ExpiryDate | 12monthsafterpurchase |
| SpecificReferences | 1.RangarajuS.etal(2009)Moleculararchitectureofmyelinatedperipheralnervesissupportedbycalorierestrictionwithaging.AgingCell.2009Apr;8(2):178-91. |
品牌介绍
Biosensis专注于神经科学领域的抗体和试剂的开发，特别是神经营养因子和神经营养因子受体。 近30年来，Biosensis一直是该领域的全球领航者和OEM供应商。除神经营养因子，我们的神经科学产品组合还被广泛用于神经退行性疾病、神经发育和神经代谢的研究。重点研究领域包括阿尔茨海默氏症（AD）、帕金森氏症（PD）和肌萎缩侧索硬化（ALS）疾病，以及自噬和代谢应激障碍，包括肥胖、代谢综合征的研究、神经免疫学和炎症。
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