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主营:抗体类、生化类试剂、ELISA试剂盒、组织染色细胞可视化试剂、针对神经科学和细胞疾病研究产品和纯化蛋白等
℡ 4000-520-616
℡ 4000-520-616
Biosensis/Rabbit antibody to phospho-calcium/calmodulin-dependent protein kinase type II subunit alpha (alpha-CaMKII, Thr253)
产品编号:R-1706-100
市  场 价:¥5940.00
场      地:美国(厂家直采)
产品分类: 抗体类>一抗>功能性抗体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$297.00
品      牌: Biosensis
公      司:Biosensis
公司分类:
Biosensis/Rabbit antibody to phospho-calcium/calmodulin-dependent protein kinase type II subunit alpha (alpha-CaMKII, Thr253)
商品介绍
DescriptionCalcium/calmodulin-stimulatedproteinkinaseII(CaMKII)iscomposedoffourdifferentchains(alpha,beta,gamma,anddelta)andisabundantlyexpressedinneurons.CaMKIIisinvolvedinregulatingmanyaspectsofneuronalfunction,includingneurotransmittersynthesisandrelease,modulationofionchannelactivityandcellulartransport.TheenzymaticfunctionofCaMKIIisregulatedbyitsmultiplephosphorylationsitesandtargetingtosub-cellularlocationsthroughinteractionswithproteinbindingpartners.PhosphorylationofThr253hasbeenidentifiedinvivoandfoundtoaltertheinteractionofCaMKIIwithbindingpartners,butnotchangeitsenzymaticactivity.Thus,phosphorylationofThr253issuggestedtomodulatefunctionalresponsesbasedonitsbindingpartnerandsubsequentlyitssub-cellularlocalization.
BatchNo.Seeproductlabel
Unitsize100uL
AntigenAsyntheticpeptide(NKMLpTINPSC)correspondingtothesequencearoundThr253(AA249-257)inalpha-CaMKIIwassynthesized,purifiedto95%puritybyHPLC,analyzedbymassspectroscopyandcoupledtodiphtheriatoxoid.
AntibodyTypePolyclonal
AccessionP11275KCC2A_RAT
ProducedinRabbit
PurityWholeserum
ApplicationsWesternBlotting(1:200–1:1000).Otherapplicationshavenotbeentested.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser.
SpecificityRat
Cross-reactivityNottested.Predictedfromgeneanalysistoreactwithhumanandmousealpha-CaMKII.
FormLyophilized
ReconstitutionReconstitutein100uLsteriledistilledwater.Centrifugetoremoveanyinsolublematerial.
StorageAfterreconstitutionoflyophilisedantibody,aliquotandstoreat-20°CforahigherstABIlity.Avoidfreeze-thawcycles.
ExpiryDate12monthsafterpurchase
SpecificReferences1.SkeldingKAetal(2012)JJCerebBloodFlowMetab32(12),2181-2192.
2.SkeldingKAetal(2010)CellSignal22(5),759-769.
3.GurdJWetal(2008)BrainRes1218,158-165.
4.MiguesPVetal(2006)JNeuRochem98(1),289-299.
GeneralReferences1.SkeldingKAet(2011)CellCycle10(4),631-639.
2.DosemeciA&JaffeH(2010)BiochemBiophysResCommun391(1),78-84.
3.SkeldingKA&RostasJAP(2009)NeurochemRes34,1792-1804.
4.Dosemeci,A.etal(1994)JBiolChem269(50),31330-31333.
品牌介绍

Biosensis专注于神经科学领域的抗体和试剂的开发,特别是神经营养因子和神经营养因子受体。 近30年来,Biosensis一直是该领域的全球领航者和OEM供应商。除神经营养因子,我们的神经科学产品组合还被广泛用于神经退行性疾病、神经发育和神经代谢的研究。重点研究领域包括阿尔茨海默氏症(AD)、帕金森氏症(PD)和肌萎缩侧索硬化(ALS)疾病,以及自噬和代谢应激障碍,包括肥胖、代谢综合征的研究、神经免疫学和炎症。

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