Description | SpectrinsareafamilyoffilamentouscytoskeletalproteinsthatfunctionasessentialscaffoldproteinsthatstABIlizetheplasmamembraneandorganizeintracellularorganelles.TheSpectrinsformintodimersandfurtherintotetramersofalphaandbetasubunits(Ref:EntrezGene).Thealpha-IIsubunitiswidelyexpressedintissuesbut,inthenervoussystem,isfoundpredominantlyinneurons. |
BatchNo. | Seeproductlabel |
Unitsize | 100µg |
Antigen | Thisantibodywasraisedagainstarecombinantconstructcontainingtheseventh,eightandninthrepeats(aminoacids676-1043)ofhumanalpha-IISpectrin.The9thspectrinrepeatalsoincludesaSrc-homology3domain.ThisconstructwasexpressedinandpurifiedfromE.coli. |
AntibodyType | monoclonal |
Isotype | IgG1 |
Clone | 3D7 |
OtherNames | SPTAN1;alphaIIspectrin;alphaFodrin;Spectrin,non-erythroidalphachain;SPTA2; |
Accession | Q13813SPTA2_HUMAN; |
Producedin | Mouse |
Applications | WB,IHC(IF).Recommendeddilutionof1:500-1,000forIHC/IFand1:5,000-10,000forWB.Theproteinisseenasamajorbandat240kDadependingonthespecies. |
Cross-reactivity | Human;bovine;porcine;rat; |
BlastURL | Clickhere |
Form | Lyophilisedwith5%trehalose |
Reconstitution | Reconstituteinsteriledistilledwater.Centrifugetoremoveanyinsolublematerial. |
Storage | Aliquotandstoreat-20°Cforahigherstabilityandat4°Cwithanappropriateantibacterialagent.Avoidfreeze-thawcycles. |
ExpiryDate | 12monthsafterpurchase |
Biosensis专注于神经科学领域的抗体和试剂的开发,特别是神经营养因子和神经营养因子受体。 近30年来,Biosensis一直是该领域的全球领航者和OEM供应商。除神经营养因子,我们的神经科学产品组合还被广泛用于神经退行性疾病、神经发育和神经代谢的研究。重点研究领域包括阿尔茨海默氏症(AD)、帕金森氏症(PD)和肌萎缩侧索硬化(ALS)疾病,以及自噬和代谢应激障碍,包括肥胖、代谢综合征的研究、神经免疫学和炎症。