Description | GABARAPishighlypositivelychargedinitsN-terminusandsharessequencehomologywithMAP1LC31Aand1B.Thisproteinclustersneurotransmitterreceptors(GABA(A)receptors)bymediatinginteractionwiththeCytoskeleton. SUBUNIT:InteractswithGABRG2,TUBA1,ULK1andNSF.Interactswithbeta-tubulinandGPHN.SUBCELLULARLOCATION:Intracytoplasmicmembrane.Cytoskeleton.LargelyassociatedwithintracellularmembranestructuresincludingtheGolgiapparatusandpost-synapticcisternae.Colocalizeswithmicrotubules.TISSUESPECIFICITY:Heart,brain,placenta,skeletalmuscle,kidneyandpancreas. |
BatchNo. | Seeproductlabel |
Unitsize | 100µl |
Antigen | Asyntheticpeptide(FEKRRSEGEKIC)correspondingtotheN-terminalofhumanGABARAPproteinhasbeenusedastheimmunogen.ThesequenceishomologouswithmouseandratformofGABARAP. |
OtherNames | Gamma-aminobutyricacidreceptor-associatedprotein;GABA(A)receptor-associatedprotein;MM46;GABARAP;FLC3B |
Accession | GBRAP_HUMAN GBRAP_MOUSE GBRAP_RAT |
Producedin | Rabbit |
Purity | Wholeserum |
Applications | IHC,immunofluorescence,WB.Adilutionof1:200to1:1000dilutionisrecommendedfortheseapplications.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser. |
Specificity | IHC,WBandELISAconfirmedthespecificityforGABARAP. |
Cross-reactivity | Human,rat.Otherspeciesnotyettested. |
Form | Lyophilised |
Reconstitution | Reconstitutein100µlofsterilewater.Centrifugetoremoveanyinsolublematerial. |
Storage | Afterreconstitutionkeepaliquotsat-20ºCforahigherstABIlity,andat4ºCwithanappropriateantibacterialagent.Glycerol(1:1)maybeaddedforanadditionalstability.Avoidrepetitivefreeze/thawcycles. |
ExpiryDate | 12monthsafterpurchase |
References | 1.WangH.etal.Nature.397:69-72(1999) 2.OkazakiN.etal.BrainRes.Mol.BrainRes.85:1-12(2000) 3.HuR.-M.etal.Proc.Natl.Acad.Sci.U.S.A.97:9543-9548(2000) 4.KnightD.etal.Biol.Chem.277:5556-5561(2002) |
Biosensis专注于神经科学领域的抗体和试剂的开发,特别是神经营养因子和神经营养因子受体。 近30年来,Biosensis一直是该领域的全球领航者和OEM供应商。除神经营养因子,我们的神经科学产品组合还被广泛用于神经退行性疾病、神经发育和神经代谢的研究。重点研究领域包括阿尔茨海默氏症(AD)、帕金森氏症(PD)和肌萎缩侧索硬化(ALS)疾病,以及自噬和代谢应激障碍,包括肥胖、代谢综合征的研究、神经免疫学和炎症。