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主营:抗体类、生化类试剂、ELISA试剂盒、组织染色细胞可视化试剂、针对神经科学和细胞疾病研究产品和纯化蛋白等
℡ 4000-520-616
℡ 4000-520-616
Biosensis/Rabbit antibody to ATG7: whole serum/R-161-100/100 µl
产品编号:R-161-100
市  场 价:¥5940.00
场      地:美国(厂家直采)
产品分类: 抗体类>一抗>功能性抗体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$297.00
品      牌: Biosensis
公      司:Biosensis
公司分类:
Biosensis/Rabbit antibody to ATG7: whole serum/R-161-100/100 µl
商品介绍
DescriptionFUNCTION:FunctionsasanE1enzymeessentialformultisubstratessuchasGABARAPL1andATG12.FormsintermediateconjugateswithGABARAPL1(GABARAPL2,GABARAPorMAP1ALC3).FormationofthefinalGABARAPL1-PEconjugateisessentialforautophagy.SUBUNIT:Homodimer(Bysimilarity).InteractswithATG3andATG12.Thecomplex,composedofATG3andATG7,playsaroleintheconjugationofATG12toATG5.SUBCELLULARLOCATION:Cytoplasm(Probable).ALTERNATIVEPRODUCTS:2namedisoformsproducedbyalternativesplicing.TISSUESPECIFICITY:Widelyexpressed,especiallyinkidney,liver,lymphnodesandbonemarrow.DOMAIN:TheC-terminalpartoftheproteinisessentialforthedimerizationandinteractionwithATG3andATG12.SIMILARITY:BelongstotheATG7family.Inyeast,ATG7appearstoberequiredforfusionofperoxisomalandvaculuolarmembranes.
BatchNo.Seeproductlabel
Unitsize100µl
AntigenAsyntheticpeptide(DSTRDRTLDQQC)correspondingtotheC-terminalofhumanAPG7proteinconjugatedtobluecarrierproteinhasbeenusedastheimmunogen.ThepeptideishomologouswiththecorrespondingsequencederivedfromAPG7proteininmouse,rat,S.cerevisiae,Macacamulatta(monkey)andCanisfamiliaris(dog).
OtherNamesAutophagy-relatedprotein7;Ubiquitin-activatingenzymeE1-likeprotein;hAGP7;APG7-like;ATG7;APG7L
AccessionATG7_HUMAN
ATG7_MOUSE
ATG7_RAT
ATG7_Saccharomycescerevisiae
ATG7_Macacamulatta
ATG7_Canisfamiliaris
ProducedinRabbit
PurityWholeserum
ApplicationsNon-reducedwesternblot:1:100;IF:acetoneor3.7%PFAfixedcells(HJLimetal2013);1:100;Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser.
SpecificityIF,WBandELISAconfirmedthespecificityforATG7.
Cross-reactivityHuman,rat.Otherspeciesnotyettested.
FormLyophilised
ReconstitutionReconstitutein100µlofsterilewater.Centrifugetoremoveanyinsolublematerial.
StorageStorelyophilizedantibodyat2-8ºC.Afterreconstitutionkeepaliquotsat-20ºCforahigherstABIlity,andat4ºCwithanappropriateantibacterialagent.Glycerol(1:1)maybeaddedforanadditionalstability.Avoidrepetitivefreeze/thawcycles.
ExpiryDate12monthsafterpurchase
SpecificReferencesChiu-WeiChen,etal(2012)Inhibitionofautophagyasatherapeuticstrategyofiron-inducedbraininjuryafterhemorrhageAutophagy,8(10):1510.
ChienW.S.etal(2011)SuppressionofautophagyinratliveratlatestageofpolymicrobialsepsisShock.2011Jan14
LeeJ.E.etal(2011)AutophagyRegulatesEmbryonicSurvivalDuringDelayedImplantationEndocrinology.2011Mar1.
RyningenAetal(2012)InhibitionofMammaliantargetofrapamycininhumanacutemyeloidleukemiacellshasdiverseeffectsthatdependontheenvironmentalinvitrostress.BoneMarrowRes.2012;2012:329061.
OhHAetal(2013)Uncoveringaroleforendocannabinoidsignalinginautophagyinpreimplantationmouseembryos.MolHumReprod.2013Feb;19(2):93-101.
References1.YuanW,etal.Mol.Biol.Cell10:1353-1366(1999).
2.TanidaI,etal.Biochem.Biophys.Res.Commun.292:256-262(2002).
3.TanidaI,etal.J.Biol.Chem.277:13739-13744(2002).
4.MizushimaN,etal.Nature395:395-398(1998).
5.JohnstonM,etal.Science265:2077-2082(1994).
6.HardingT.M,etal.J.CellBiol.131:591-602(1995).
7.KimJ,etal.Mol.Biol.Cell10:1337-1351(1999).
8.KomatsuM,etal.J.Biol.Chem.276:9846-9854(2001).
9.KlionskyD.J,etal.Dev.Cell5:539-545(2003).
10.chimuraY,etal.J.Biol.Chem.279:40584-40592(2004).
品牌介绍

Biosensis专注于神经科学领域的抗体和试剂的开发,特别是神经营养因子和神经营养因子受体。 近30年来,Biosensis一直是该领域的全球领航者和OEM供应商。除神经营养因子,我们的神经科学产品组合还被广泛用于神经退行性疾病、神经发育和神经代谢的研究。重点研究领域包括阿尔茨海默氏症(AD)、帕金森氏症(PD)和肌萎缩侧索硬化(ALS)疾病,以及自噬和代谢应激障碍,包括肥胖、代谢综合征的研究、神经免疫学和炎症。

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